Quiz Flashcards

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1
Q

What are the starting doses of SSRIs?

A
Fluoxestine 20mg
Paxil 20mg
Zoloft 50mg
Fluvox 50mg
Celexa 20mg
Lexapro 10mg
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2
Q

What are the starting doses of SNRIs?

A

Effexor 37.5-75mg

Cymbalta 30-60mg

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3
Q

What is the starting dose of mirtazapine?

A

15mg

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4
Q

What is the starting dose of wellbutrin?

A

100-150mg

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5
Q

What is the duration of MDD therapy?

A

4-8 weeks

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6
Q

What is the diagnostic criteria for MDD?

A

2+ weeks

5+ sx

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7
Q

What are the sx of MDD?

A
Sleep (insomnia/hypersomnia)
Interest (loss of interest/pleasure)
Guilt (feeling of worthlessness; excessive/inappropriate guilt)
Energy (Fatigue/loss of energy)
Concentration
Appetite (change in appetite/wt)
Psychomotor
Suicidal thoughts
Low mood
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8
Q

What is the diagnostic criteria for mania?

A

3+ sx
1+ week
Or any duration if hospitalization is necessary
Cause marked impairment

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9
Q

What is the diagnostic criteria for hypomania?

A

3+ sx
4+ consecutive days
Not severe enough to cause marked impairment

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10
Q

What are the sx of mania/hypomania?

A
Grandiose; increase self-esteem
Increased activity (goal directed/highly risky)
Decreased judgement
Distractibility; flight of ideas
Irritability
Need less sleep
Elevated mood
Speedy talking/thoughts
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11
Q

What are the diagnostic criteria for rapid cycling?

A

4+ mood episodes (MDD, manic, mixed, hypomanic)/year

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12
Q

What are the criteria for cyclothymia?

A

Numerous periods with hypomanic sx and depressive sx for at least 2 years that do not meet criteria for MDD
For more than 2 months at a time
Present for at least 1/2 the time

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13
Q

What is the criteria for mixed BD?

A

Patient w/sx of both mania and depression simultaneously

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14
Q

What are the characteristics of BP I?

A
Mania
Psychosis often present
Impaired functioning
Hospitalization often required
Duration = months
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15
Q

What are the characteristics of BP II?

A
Hypomania
Psychosis often not present
Slightly impaired to improved functioning
Hospitalization not required
Duration = weeks
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16
Q

What are the first line therapy for MDD?

A

SSRI
SNRI
Mirtazapine
Bupropion

17
Q

What are the first line therapy for acute mania?

A

Lithium
VPA
SGA
Consider 2 drug combination, if severe (MS + SGA)
CBZ 1st or 2nd line depending on guideline

18
Q

What are the first line therapies for BD?

A

Lithium
Lamictal
Quetiapine

19
Q

What are the first line therapies for Mixed BD?

A

CBZ
VPA
Olanzapine

20
Q

What length of time is considered an adequate trial before adjusting/augmenting MDD therapy?

A

4-8 weeks

21
Q

What do we do if a patient with MDD is non-responsive to therapy?

A

Change/switch to a drug in a different/same class

22
Q

What do we do if a patient with MDD is partially responsive to therapy?

A

Ensure optimized dose
Can switch/augment
Augment/adjunctive therapy should target remaining sx
Augmentation is better strategy when response is seen

23
Q

What is the gold standard for augmentation in partial response for MDD?

A

Lithium

24
Q

What drugs are options for MDD augmentation/adjustments?

A
AAP (low dose SGAs in MDD w/o psychosis)
Anticonvulsants
Omega-3
Folic acid
Psychostimulants
Buspar
Ketamine
25
Q

Where is psychostimulants in MDD partial response therapy?

A

Controversial
May consider short course if severe depression (fatigue, not getting out of bed or if immediate response required)
May exacerbate anxiety
Abuse potential

26
Q

What is the DOT of MDD?

A

12 months with the first episode for most patients
12-26 months for patients w/recurrent and/or severe MDD
Potentially indefinitely depending on severity

27
Q

What is the DOT of BD?

A

Typically lifelong

28
Q

Which medication decreases SI in MDD?

A

Lithium

29
Q

Which screening tool in MDD is used for screening?

A

PHQ-9

30
Q

Who gets PHQ-9 and HAM-D?

A

All adults at least every 5 years

Those at high risk

31
Q

Who is at high risk in MDD?

A
PMH
FH of depression/bipolar disorder
Chronic illness ("frequent flyers")
High utilization of services
Pregnancy
32
Q

What is the screening tool for BD?

A

MDQ

33
Q

Who gets screening with BD?

A

Young adults - 40’s with RFs

Patients not feeling themselves

34
Q

What are RFs for BD?

A

FH, stressors, head trauma, environment

Medical diagnosis, psychitric diagnosis or medications known to contribute

35
Q

What is the role of antidepressants in BD?

A

Should be used with mood stabilizers

Can cause “switching”

36
Q

How do we treat comorbid anxiety in patients with BD?

A

Gabapentin

Quetiapine