Bipolar Disorder Flashcards

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1
Q

What is the definition of bipolar disorder?

A

Spectrum of cyclic mood disorder (think rollercoaster)

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2
Q

How do bipolar patients go through sx?

A

Cycle between depression and mania/hypomania

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3
Q

What is the first BD episode in males most likely to be?

A

Manic episode

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4
Q

What is the first BD episode in females more likely to be?

A

Major Depressive Episode

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5
Q

How often are BD patients symptomatic?

A

Frequently (almost 50% of the time

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6
Q

If a patient with BD has co-morbidities, how does that affect treatment?

A

Requires lots of care and intervention

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7
Q

What hypothesis does BD treatment target?

A

Neurotransmitter hypothesis

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8
Q

What are the RFs for BD?

A

Genetic component = FH (BD, MDD, Suicide)
Stressors (divorce, legal problems, financial problems, substance abuse/use, job loss)
Medications (antidepressants, decongestants, stimulants, EtOH, cocaine, amphetamines, caffeine, corticosteroids)

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9
Q

What is the essential feature of BD?

A

Characterized by the occurrence of manic episodes, hypomanic episodes, or mixed episodes
Often individuals have also had major depressive episodes

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10
Q

What is the average age of BD onset?

A

20 yo

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11
Q

What is the average amount of episodes in a 10 year period?

A

4 episodes

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12
Q

What implications does BD have?

A

Neuropsychologic implications

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13
Q

What is rapid cycling?

A

4 or more mood episodes in a 12 month period

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14
Q

Who should be screened for BD?

A

18-40 yos with RFs

Patients that may describe not feeling like themselves at times

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15
Q

What are the tools for psychometric screening?

A

MDQ

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16
Q

What is the criteria for Manic Episodes?

A

At least 1 week (or any duration of hospitalization)
3 or more GIDDINES sx
Severe enough to cause marked impairment

17
Q

What does GIDDINES stand for?

A
Grandiose; increased self-esteem
Increased activity (goal directed/highly risk)
Decreased judgement
Distractibility; flight of ideas
Irritability
Need less sleep
Elevated mood
Speedy talking
18
Q

What is the criteria for hypomanic episodes?

A

At least 4 consecutive days
3 or more GIDDINES sx
Not severe enough to cause marked impairment

19
Q

What is Bipolar Type I?

A
Mania
Psychosis often present
Impaired functioning
Hospitalization often required
Duration = months
20
Q

What is Bipolar Type II?

A
Hypomania
No psychosis
Functioning slightly impaired to improved
Hospitalization not required
Duration = weeks
21
Q

What is Cyclothemia?

A

At least 2 years with periods of hypomanic and depressive symptoms
Does not occur for more than 2 months at a time but is present > 1/2 the time

22
Q

What is mixed BD?

A

Patient with sx of both mania and depression simultaneously

23
Q

If a patient has severe sx, how does that affect diagnosis?

A

Typically requires hospitalization and makes diagnosis more difficult
Does not fall under DSM-5 criteria

24
Q

How long do medications take for onset of action or sx improvement?

A

7-10 days

25
Q

How long do medications take to improve mood symptoms?

A

4-6 weeks

26
Q

What is DOT for BD?

A

Typically life long, once diagnosis is made

27
Q

What are 1st line therapies for BD?

A
Lithium
VPA
AAP/SGA
Consider 2 drug combo (MS + AAP)
CBZ 1st or 2nd line depending on guideline (has FDA indication)
28
Q

What are the 2nd line therapies for BD?

A

Try a different first line therapy (little to no response)
Consider 2 drug combo (if partial response)
CBZ or OxCBZ (generally not used)

29
Q

What do we use to monitor response/effectiveness of drug therapy in Bipolar/mania?

A

YMRS

30
Q

What are the first line therapies for acute bipolar depression?

A
Lithium
Lamotrigine
Quetiapine
VPA
or olanzapine/fluoxetine combo
31
Q

What are the second line monotherapies for bipolar depression?

A

Try a different first line therapy

Lurasidone (FDA indication)