Quiz 4 Pharmacology

Question 1

Which three alpha-1 inhibitors can be used to treat BPH as well as hypertension?

Answer 1

Prazosin
Doxazosin
Terazosin

Question 2

Which two alpha-1 inhibitors can be used to treat BPH but are not approved for hypertension?

Answer 2

Tamsulosin
Silodosin

Question 3

Which 5 drugs are notable alpha-1 receptor antagonists (competitive antagonsim)?

Answer 3

Prazosin
Doxazosin
Terazosin
Tamsulosin
Silodosin

Question 4

What are notable side effects of alpha-1 inhibitors?

Answer 4

-Orthostatic hypertension
(especially 1st dose)
- Tachycardia
-Retrograde ejaculation

Question 5

What two notable drugs are 5a-reductase inhibitors?

Answer 5

Finasteride
Dutasteride

Question 6

What are 5a-reductase inhibitors used to treat?

Answer 6

-BPH (usually with alpha blocker)
-Can promote hair growth in androgenic alopecia

Question 7

What are notable side effects with 5a-reductase use?

Answer 7

-Impotence (>10%)
-Decreased libido
-Gynecomastia

-CI in pregnancy

Question 8

What notable medications are used as anticholinergics?

Answer 8

Oxybutynin
Tolterodine
Trospium

Question 9

What are anticholingergics used to treat?

Answer 9

Symptoms of overactive bladder (neurologic or non-neurologic causes)

Question 10

What are notable side effects of anticholinergic use?

Answer 10

Dizziness, drowsiness, xerostomia, constipation, nausea

Question 11

What are the three notable PDE5 inhibitors?

Answer 11

Sildenafil
Tadalafil
Vardenafil

Question 12

What are PDE5 inhibitors used to treat?

Answer 12

-Erectile dysfunction
-Pulmonary arterial hypertension

Question 13

What are notable side effects of using PDE5 inhibitors?

Answer 13

-HA
-Flushing
-Nasal congestion
-Back pain
-Muscle aches
-priapism

CI use with organic nitrates (nitroglycerin) -> severe hypotension