Quiz 3 Drugs Flashcards
What is the generic/brand name of the principal VEGF monoclonal antibody used in MCC? What is its MoA?
What drugs match this PK?
Bevacizumab (Avastin)
Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Nivolumab (Opdivo)
Rituximab (Rituxan)
What drug matches this acute toxicity profile?
Bevacizumab (Avastin)
What drug matches this delayed toxicity profile? BBW
Bevacizumab (Avastin)
What is the route of administration of all VEGFR TKIs?
oral
What are notable PK for all VEGFR TKIs?
Primarily metabolized by liver, mostly CYP3A4
In addition to sharing the acute/delayed toxicities of VEGF mAbs, what are significant “off-target” toxicities of VEGFR TKIs?
HFS, QT prolongation, hypothyroidism, fatigue, N/V/D
What is the generic/brand name of the principal EGFR mAb used in MCC? What is its MoA?
Which drugs match this acute toxicity profile?
Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Nivolumab (Opdivo)
Rituximab (Rituxan)
(also Bevacizumab)
Which drug matches this delayed toxicity profile?
Cetuximab (Erbitux)
What is the generic/brand name of the principal EGFR TKI used in MCC? What is its MoA?
Which drug matches this PK?
Erlotinib (Tarceva)
Which drug matches the following acute toxicity profile?
Erlotinib (Tarceva)
Which drug matches the following delayed toxicity profile?
Erlotinib (Tarceva)
What are significant drug interactions of VEGFR TKIs?
CYP3A4 inhibitors/inducers