Quiz 3 Drugs Flashcards by Spencer Barlow

Q

What is the generic/brand name of the principal VEGF monoclonal antibody used in MCC? What is its MoA?

A

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Q

What drugs match this PK?

A

Bevacizumab (Avastin)
Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Nivolumab (Opdivo)
Rituximab (Rituxan)

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Q

What drug matches this acute toxicity profile?

A

Bevacizumab (Avastin)

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Q

What drug matches this delayed toxicity profile? BBW

A

Bevacizumab (Avastin)

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Q

What is the route of administration of all VEGFR TKIs?

A

oral

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Q

What are notable PK for all VEGFR TKIs?

A

Primarily metabolized by liver, mostly CYP3A4

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Q

In addition to sharing the acute/delayed toxicities of VEGF mAbs, what are significant “off-target” toxicities of VEGFR TKIs?

A

HFS, QT prolongation, hypothyroidism, fatigue, N/V/D

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Q

What is the generic/brand name of the principal EGFR mAb used in MCC? What is its MoA?

A

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Q

Which drugs match this acute toxicity profile?

A

Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Nivolumab (Opdivo)
Rituximab (Rituxan)
(also Bevacizumab)

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Q

Which drug matches this delayed toxicity profile?

A

Cetuximab (Erbitux)

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Q

What is the generic/brand name of the principal EGFR TKI used in MCC? What is its MoA?

A

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Q

Which drug matches this PK?

A

Erlotinib (Tarceva)

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Q

Which drug matches the following acute toxicity profile?

A

Erlotinib (Tarceva)

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Q

Which drug matches the following delayed toxicity profile?

A

Erlotinib (Tarceva)

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Q

What are significant drug interactions of VEGFR TKIs?

A

CYP3A4 inhibitors/inducers

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Q

What are significant drug interactions of Erlotinib (Tarceva)?

A

Q

What is the generic/brand name of the principal HER2 mAb used in MCC? What is its MoA?

A

Q

Which drug matches this delayed toxicity profile?

A

Trastuzumab (Herceptin)

Q

What is the generic/brand name of the principal BCR-ABL TKI used in MCC? What is its MoA?

A

Q

Which drug matches the following PK?

A

Imatinib (Gleevec)

Q

Which drug matches the following acute toxicity profile?

A

Imatinib (Gleevec)

Q

Which drug matches the following delayed toxicity profile?

A

Imatinib (Gleevec)

Q

Which drug has the following significant drug interactions?

A

Imatinib (Gleevec)

Q

What is the generic/brand name of the principal anti-PD-1 agent used in MCC? What is its MoA?

A

Which drug matches this delayed toxicity profile?

Nivolumab (Opdivo)

Whichs drugs have the significant drug reactions listed here?

Nivolumab (Opdivo) Axicabtagene Ciloleucel (Yescarta)

Are PD-1/PD-L1 inhibitors more or less specific than CTLA-4 inhibitors?

What is the generic/brand name of the principal Chimeric receptor modified T- cell (CAR T) agent used in MCC? What is the MoA?

Which drug has the following PK?

Axicabtagene Ciloleucel (Yescarta)

Which drug matches the following acute toxicity profile?

Axicabtagene Ciloleucel (Yescarta)

What is the generic/brand name of the principal anti-CD20 drug used in MCC? What is its MoA?

What drug matches this delayed toxicity profile?

Rituximab (Rituxan)

What is the generic/brand name of the principal anti-BRAF drug used in MCC? What is the MoA?

What drug matches this PK?

Dabrafenib (Tafinlar)

What drug matches this acute toxicity profile?

Dabrafenib (Tafinlar)

What drug matches this delayed toxicity profile?

Dabrafenib (Tafinlar)

What drug has the following significant drug interaction?

Dabrafenib (Tafinlar)

Which targeted cancer agents are metabolized through CYP3A4?

VEGFR TKIs Erlotinib (Tarceva) Imatinib (Gleevec) Dabrafenib (Tafinlar)