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MCC > Quiz 3 Drugs > Flashcards

Quiz 3 Drugs Flashcards

1
Q

What is the generic/brand name of the principal VEGF monoclonal antibody used in MCC? What is its MoA?

A
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2
Q

What drugs match this PK?

A

Bevacizumab (Avastin)
Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Nivolumab (Opdivo)
Rituximab (Rituxan)

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3
Q

What drug matches this acute toxicity profile?

A

Bevacizumab (Avastin)

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4
Q

What drug matches this delayed toxicity profile? BBW

A

Bevacizumab (Avastin)

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5
Q

What is the route of administration of all VEGFR TKIs?

A

oral

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6
Q

What are notable PK for all VEGFR TKIs?

A

Primarily metabolized by liver, mostly CYP3A4

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7
Q

In addition to sharing the acute/delayed toxicities of VEGF mAbs, what are significant “off-target” toxicities of VEGFR TKIs?

A

HFS, QT prolongation, hypothyroidism, fatigue, N/V/D

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8
Q

What is the generic/brand name of the principal EGFR mAb used in MCC? What is its MoA?

A
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9
Q

Which drugs match this acute toxicity profile?

A

Cetuximab (Erbitux)
Trastuzumab (Herceptin)
Nivolumab (Opdivo)
Rituximab (Rituxan)
(also Bevacizumab)

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10
Q

Which drug matches this delayed toxicity profile?

A

Cetuximab (Erbitux)

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11
Q

What is the generic/brand name of the principal EGFR TKI used in MCC? What is its MoA?

A
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12
Q

Which drug matches this PK?

A

Erlotinib (Tarceva)

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13
Q

Which drug matches the following acute toxicity profile?

A

Erlotinib (Tarceva)

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14
Q

Which drug matches the following delayed toxicity profile?

A

Erlotinib (Tarceva)

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15
Q

What are significant drug interactions of VEGFR TKIs?

A

CYP3A4 inhibitors/inducers

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16
Q

What are significant drug interactions of Erlotinib (Tarceva)?

17
Q

What is the generic/brand name of the principal HER2 mAb used in MCC? What is its MoA?

18
Q

Which drug matches this delayed toxicity profile?

A

Trastuzumab (Herceptin)

19
Q

What is the generic/brand name of the principal BCR-ABL TKI used in MCC? What is its MoA?

20
Q

Which drug matches the following PK?

A

Imatinib (Gleevec)

21
Q

Which drug matches the following acute toxicity profile?

A

Imatinib (Gleevec)

22
Q

Which drug matches the following delayed toxicity profile?

A

Imatinib (Gleevec)

23
Q

Which drug has the following significant drug interactions?

A

Imatinib (Gleevec)

24
Q

What is the generic/brand name of the principal anti-PD-1 agent used in MCC? What is its MoA?

25
Q

Which drug matches this delayed toxicity profile?

A

Nivolumab (Opdivo)

26
Q

Whichs drugs have the significant drug reactions listed here?

A

Nivolumab (Opdivo)
Axicabtagene Ciloleucel (Yescarta)

27
Q

Are PD-1/PD-L1 inhibitors more or less specific than CTLA-4 inhibitors?

28
Q

What is the generic/brand name of the principal Chimeric receptor modified T- cell (CAR T) agent used in MCC? What is the MoA?

29
Q

Which drug has the following PK?

A

Axicabtagene Ciloleucel (Yescarta)

30
Q

Which drug matches the following acute toxicity profile?

A

Axicabtagene Ciloleucel (Yescarta)

31
Q

What is the generic/brand name of the principal anti-CD20 drug used in MCC? What is its MoA?

32
Q

What drug matches this delayed toxicity profile?

A

Rituximab (Rituxan)

33
Q

What is the generic/brand name of the principal anti-BRAF drug used in MCC? What is the MoA?

34
Q

What drug matches this PK?

A

Dabrafenib (Tafinlar)

35
Q

What drug matches this acute toxicity profile?

A

Dabrafenib (Tafinlar)

36
Q

What drug matches this delayed toxicity profile?

A

Dabrafenib (Tafinlar)

37
Q

What drug has the following significant drug interaction?

A

Dabrafenib (Tafinlar)

38
Q

Which targeted cancer agents are metabolized through CYP3A4?

A

VEGFR TKIs
Erlotinib (Tarceva)
Imatinib (Gleevec)
Dabrafenib (Tafinlar)

MCC (10 decks)

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