MCC Final drugs

Question 1

What is the generic/brand name of the principal topoisomerase I inhibitor for MCC? What is its MoA?

Answer 1

Question 2

In the topoisomerase inhibitor, microtubule targeting agents, and antbiotic chemotherapy classes of drugs, which are delivered via IV?

Answer 2

Irinotecan
Doxorubicin (also IV push)
Etoposide (also PO)
Vincristine
Paclitaxel
Bleomycin

Question 3

What is the route of administration of Goserelin?

Answer 3

IM/SubQ

Question 4

Which topoisomerase inhibitors and microtubule targeting agents are metabolized by CYP3A4 enzymes?

Answer 4

Irinotecan (also CYP2B6)
Etoposide
Vincristine
Paclitaxel

Question 5

What are notable PK for Irinotecan?

Answer 5

Question 6

Which topoisomerase inhibitor matches this acute toxicity profile?

Answer 6

Irinotecan

Question 7

Which topoisomerase inhibitor matches this delayed toxicity profile? What is additionally important to consider?

Answer 7

Irinotecan; diarrhea is main DLT, can be treated with anti-cholinergics (early) or loperimide (late)

Question 8

For which anti-cancer drug would the following note apply?

Answer 8

Irinotecan

Question 9

What is the generic/brand name of the principal topoisomerase II inhibitor (only TI II inhibition) used in MCC? What is its MoA?

Answer 9

Question 10

What are notable PK for etoposide?

Answer 10

Question 11

Which topoisomerase inhibitor matches this acute toxicity profile?

Answer 11

Etoposide

Question 12

Which topoisomerase inhibitor matches this delayed toxicity profile? What is the DLT?

Answer 12

Etoposide; myelosuppression

Question 13

What is the generic/brand name of the principle Anthracycline/Topoisomerase II inhibitor for MCC? What is its MoA?

Answer 13

Question 14

What are the notable PK of doxorubicin?

Answer 14

Hepatic metabolism

Question 15

Which topoisomerase inhibitor best matches this acute toxicity profile?

Answer 15

Doxorubicin

Question 16

Which topoisomerase inhibitor best matches this delayed toxicity profile? What is the DLT?

Answer 16

Doxorubicin; lifetime doseage is monitored due to cardiotoxicity; can lead directly to CHF

Question 17

What is the generic/brand name of the microtubule targeting agent (vinca alkaloid) that is principally used in MCC? What is the MoA?

Answer 17

Question 18

What are notable PK for both of the principle microtubule targeting agents used in MCC?

Answer 18

Question 19

Which of the topoisomerase inhibitors and microtubule targeting agents is acutely fatal if given intrathecally?

Answer 19

Vincristine (Oncovin)

Question 20

Which of the topoisomerase inhibitors and microtubule targeting agents matches this delayed toxicity profile?

Answer 20

Vincristine (Oncovin)

Question 21

What is the generic/brand name for the microtubule targeting agent (taxane) principally used for MCC?What is the MoA?

Answer 21

Question 22

Which cancer drug matches this acute toxicity profile?

Answer 22

Paclitaxel (Taxol)

Question 23

Which cancer drug matches this delayed toxicity profile? What is the DLT?

Answer 23

Paclitaxel (Taxol); myelosuppression

Question 24

What is the generic/brand name of the principal antibiotic chemotherapy used in MCC? What is the MoA?

Answer 24

Question 25

What is the notable PK for Bleomycin?

Answer 25

Question 26

What is notable about the acute toxicity profile of Bleomycin?

Answer 26

No significant acute toxicity

Question 27

Which cancer drug matches this delayed toxicity profile?

Answer 27

Bleomycin

Question 28

What are the significant drug-drug interactions with Bleomycin?

Answer 28

Question 29

What is the notable PK of tamoxifen?

Answer 29

Question 30

Which cancer drug matches this delayed toxicity profile?

Answer 30

Tamoxifen

Question 31

What are the significant drug-drug interactions of tamoxifen?

Answer 31

Strong CYP2D6 inhibitors

Question 32

What is the generic/brand name of the principal PHRH agonist used in MCC? What is the MoA?

Answer 32

Goserelin; LHRH analogs compete for binding to hypothalamus causing initial spike of LH and FSH, followed by downregulation of the receptors (negative feedback)

Question 33

What is the route of administration for Goserelin?

Answer 33

IM/SubQ

Question 34

What is the notable PK for Goserelin?

Answer 34

peptide hydrolysis

Question 35

What cancer drug matches this delayed toxicity profile?

Answer 35

Goserelin

Question 36

What drug can be given to treat the acute toxicity of Irinotecan?

Answer 36

atropine (anti-cholinergic)

Question 37

What drug can be given to treat the delayed toxicity or Irinotecan?

Answer 37

loperamide