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MCC > MCC Final drugs > Flashcards

MCC Final drugs Flashcards

1
Q

What is the generic/brand name of the principal topoisomerase I inhibitor for MCC? What is its MoA?

A
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2
Q

In the topoisomerase inhibitor, microtubule targeting agents, and antbiotic chemotherapy classes of drugs, which are delivered via IV?

A

Irinotecan
Doxorubicin (also IV push)
Etoposide (also PO)
Vincristine
Paclitaxel
Bleomycin

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3
Q

What is the route of administration of Goserelin?

A

IM/SubQ

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4
Q

Which topoisomerase inhibitors and microtubule targeting agents are metabolized by CYP3A4 enzymes?

A

Irinotecan (also CYP2B6)
Etoposide
Vincristine
Paclitaxel

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5
Q

What are notable PK for Irinotecan?

A
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6
Q

Which topoisomerase inhibitor matches this acute toxicity profile?

A

Irinotecan

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7
Q

Which topoisomerase inhibitor matches this delayed toxicity profile? What is additionally important to consider?

A

Irinotecan; diarrhea is main DLT, can be treated with anti-cholinergics (early) or loperimide (late)

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8
Q

For which anti-cancer drug would the following note apply?

A

Irinotecan

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9
Q

What is the generic/brand name of the principal topoisomerase II inhibitor (only TI II inhibition) used in MCC? What is its MoA?

A
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10
Q

What are notable PK for etoposide?

A
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11
Q

Which topoisomerase inhibitor matches this acute toxicity profile?

A

Etoposide

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12
Q

Which topoisomerase inhibitor matches this delayed toxicity profile? What is the DLT?

A

Etoposide; myelosuppression

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13
Q

What is the generic/brand name of the principle Anthracycline/Topoisomerase II inhibitor for MCC? What is its MoA?

A
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14
Q

What are the notable PK of doxorubicin?

A

Hepatic metabolism

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15
Q

Which topoisomerase inhibitor best matches this acute toxicity profile?

A

Doxorubicin

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16
Q

Which topoisomerase inhibitor best matches this delayed toxicity profile? What is the DLT?

A

Doxorubicin; lifetime doseage is monitored due to cardiotoxicity; can lead directly to CHF

17
Q

What is the generic/brand name of the microtubule targeting agent (vinca alkaloid) that is principally used in MCC? What is the MoA?

A
18
Q

What are notable PK for both of the principle microtubule targeting agents used in MCC?

A
19
Q

Which of the topoisomerase inhibitors and microtubule targeting agents is acutely fatal if given intrathecally?

A

Vincristine (Oncovin)

20
Q

Which of the topoisomerase inhibitors and microtubule targeting agents matches this delayed toxicity profile?

A

Vincristine (Oncovin)

21
Q

What is the generic/brand name for the microtubule targeting agent (taxane) principally used for MCC?What is the MoA?

A
22
Q

Which cancer drug matches this acute toxicity profile?

A

Paclitaxel (Taxol)

23
Q

Which cancer drug matches this delayed toxicity profile? What is the DLT?

A

Paclitaxel (Taxol); myelosuppression

24
Q

What is the generic/brand name of the principal antibiotic chemotherapy used in MCC? What is the MoA?

A
25
Q

What is the notable PK for Bleomycin?

A
26
Q

What is notable about the acute toxicity profile of Bleomycin?

A

No significant acute toxicity

27
Q

Which cancer drug matches this delayed toxicity profile?

A

Bleomycin

28
Q

What are the significant drug-drug interactions with Bleomycin?

A
29
Q

What is the notable PK of tamoxifen?

A
30
Q

Which cancer drug matches this delayed toxicity profile?

A

Tamoxifen

31
Q

What are the significant drug-drug interactions of tamoxifen?

A

Strong CYP2D6 inhibitors

32
Q

What is the generic/brand name of the principal PHRH agonist used in MCC? What is the MoA?

A

Goserelin; LHRH analogs compete for binding to hypothalamus causing initial spike of LH and FSH, followed by downregulation of the receptors (negative feedback)

33
Q

What is the route of administration for Goserelin?

A

IM/SubQ

34
Q

What is the notable PK for Goserelin?

A

peptide hydrolysis

35
Q

What cancer drug matches this delayed toxicity profile?

A

Goserelin

36
Q

What drug can be given to treat the acute toxicity of Irinotecan?

A

atropine (anti-cholinergic)

37
Q

What drug can be given to treat the delayed toxicity or Irinotecan?

A

loperamide

MCC (10 decks)

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