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Pathoma Carcinogenesis Flashcards

1
Q

What type of carcinoma has an important relationship with Aflatoxins?

A

Hepatocellular carcinoma

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2
Q

What is the nature of Aflatoxins?

A

They are derived from Aspergillus, which can contaminate stored grains

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3
Q

Alkylating agents have the highest risk of causing what kind of cancer?

A

Leukemia/lymphoma

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4
Q

What types of cancer does alcohol have a relationship with?

A

-Squamous cell carcinoma of oropharnyx, upper esophagus
-Pancreatic carcinoma
-Hepatocellular carcinoma

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5
Q

What three significant carcinogens are found in cigarette smoke?

A

Polycyclic hydrocarbons, arsenic and naphthylamine

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6
Q

What cancers is arsenic associated with?

A

-squamous cell carcinoma of the skin
-lung cancer
-angiosarcoma of liver

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7
Q

What cancers is asbestos associated with?

A

-lung carcinoma
-mesothelioma

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8
Q

Is asbestos exposure more likely to lead to lung cancer or mesothelioma?

A

lung cancer is more likely than mesothelioma

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9
Q

What cancers is cigarette smoke associated with?

A

carcinoma of the oropharnyx, esophagus, lung, kidney, and bladder

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10
Q

What is the most important carcinogen in cigarette smoke?

A

polycyclic hydrocarbons

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11
Q

What carcinogen is found in smoked meats and responsible for high rates of stomach carcinoma in Japan?

A

Nitrosamines

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12
Q

Naphthylamine is associated with what kind of cancer?

A

urothelial carcinoma of bladder

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13
Q

Vinyl chloride is associated with what kind of cancer?

A

angiosarcoma of the liver

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14
Q

What is the most common means of exposure to vinyl chloride?

A

Occupationa exposure; used to make PVC for use in pipes

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15
Q

Nickel, chromium, berylium or silica are associated with what kind of cancer?

A

lung carcinoma

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16
Q

What are the 5 notable oncogenic viruses?

17
Q

What cancers are associated with EBV?

A

Nasopharyngeal carcinoma, Burkitt lymphoma, and CNS lymphoma in AIDS

18
Q

What cancers are associated with HHV-8?

A

Kaposi sarcoma

19
Q

What cancers are associated with HBV and HCV?

A

Hepatocellular carcinoma

20
Q

What cancers are associated with HTLV-1?

A

Adult T-cell leukemia/lymphoma

21
Q

What cancers are associated with High0risk HPV (certain subtypes)

A

squamous cell carcinoma of vulva, vagina, anus, and cervix; adenocarcinoma of cervix

22
Q

Which cancers are associated with ionizing radiation?

A

AML, CML, and papillary carcinoma of the thyroid

23
Q

Which cancers are associated with nonionizing radiation (UVB is most common)

A

Basal cell carcinoma, squamous cell carcinoma, and melanoma of skin

MCC (10 decks)

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