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Clinical Chemistry 1 > Quiz 3 crossword > Flashcards

Quiz 3 crossword Flashcards

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1
Q

_______ cells are active phagocytes that engulf bacteria, old RBCs, toxins, debris from blood flowing through sinusoids

A

Kuppfer

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2
Q

Bilirubin conjugated w/ 2 glucuronic acid molecules

A

Direct

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3
Q

A chronic, lifelong conditinon in which the body cannot produce or cannot use insulin properly

A

Diabetes mellitus

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4
Q

Enzyme that helps digest carbs

A

Amylase

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5
Q

Plot in which reverse of Vmax = y-intercept

A

Lineweaver-Burk

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6
Q

Chronic liver disease characterized pathologically by fibrosis and conversion of normal liver architecture into structurally abnormal lobules

A

Cirrhosis

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7
Q

Condition characterized by yellow discolouration of skin, sclera, mucous membranes caused by elevated bilirubin levels

A

Jaundice

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8
Q

Waste product from the degradation of the heme portion of old RBCs

A

Bilirubin

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9
Q

The product of amino acid and protein catabolism; elevated levels associated w/ impending hepatic coma and Reye;s syndrome

A

Ammonia

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10
Q

Indicated by negative HbsAg and Anti-HBc and positive HBs antibody

A

Immunization

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11
Q

The stoppage or obstruction of the flow of bile from intrahepatic causes, obstruction of bile duct by gallstones, or any process that blocks the bile duct

A

Cholestasis

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12
Q

Development of both HBs and HBc antibodies indicates

A

Recovery

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13
Q

Autosomal recessive disorder resulting in increased serum total bilirubin and presence of bilirubin in the urine

A

Dubin-Johnson

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14
Q

Enzyme that is higher in post-hepatic obstruction compared to intrahepatic obstructions

A

GGT

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15
Q

Analytical method involves hydrolysis of starch to release iodine

A

Amyloclastic

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16
Q

Tablet test for analysis of bilirubin in urine

A

Ictotest

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17
Q

Inhibition which results in increased slope and y-intercept when plotted on Lineweaver-Burk plot

A

Non-competitive

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18
Q

Sudden inflammation of the pancreas

A

Acute pancreatitis

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19
Q

Autosomal recessive disorder of copper metabolism associated with low levels of ceruloplasmin

A

Wilson’s disease

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20
Q

An inflammatory condition of the pancreas most often caused by excessive alcohol consumption

A

Chronic pancreatitis

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21
Q

Principle based on the production of a colored product in bilirubin analysis

A

Diazo

22
Q

The geometric shape of a protein composed of a single polypeptide chain

A

Tertiary

23
Q

Liver enzyme that catalyzes the reaction of aspartate and oxoglutarate

A

AST

24
Q

Transmission of Hep A and E viruses

A

Fecal-oral

25
Q

Group of enzymes that catalyze the transfer of amino groups

A

Aminotransferases

26
Q

Aminotransferase that is more liver-specific and diagnostic in hepatocellular disorders

A

ALT

27
Q

________ syndrome: unconjugated hyperbilirubinemia involving a protein with active transport of bilirubin by ligandin through the hepatocyte cell membrane to the microsome

A

Gilbert’s disease

28
Q

Result of bacterial action on conjugated bilirubin

A

Urobilinogen

29
Q

Condition differentiated from other cases of increased amylase by amylase creatinine clearance ratio

A

Macroamylasemia

30
Q

Condition that occurs when pancreas fails to provide the necessary amount of digestive enzymes

A

Pancreatic insufficiency

31
Q

Jaundice as a result of increased hemolysis and excessive destruction of RBCs leading to increased bilirubin

A

Pre-hepatic

32
Q

Enzyme that catalyzes the breakdown of fats to fatty acids and glycerol

A

Lipase

33
Q

Virus that is dependent on another virus to replicate

A

HDV

34
Q

Enzyme which oxidizes bilirubin to biliverdin

A

Bilirubin oxidase

35
Q

Enzymes that differ in amino acid sequences but catalyze the same chemical reaction

A

Isoenzyme

36
Q

Lined by Kuppfer cells

A

Sinusoid

37
Q

The concentration of substrate which permits the enzymes to achieve half Vmax

A

Km

38
Q

Particle of HBV which consists of a core and an envelope

A

Dane

39
Q

Antibody usually indicating acute infection of hepatitis

A

IgM

40
Q

Mumps or swelling of the major salivary glands

A

Parotitis

41
Q

Fibrosing disease leading to non-alcoholic steatohepatitis

A

NAFLD

42
Q

Enzyme that can be used to differentiate bone disorders from liver disorders

A

GGT

43
Q

Location in the liver between a hepatocyte and a sinusoid

A

Space of Disse

44
Q

Reaction that has a rate independent of the concentration of the reactant(s)

A

Zero-order

45
Q

Infiltration of liver cells with fat

A

Steatosis

46
Q

Enzyme that is elevated in liver and bone disorders

A

ALP

47
Q

Medications that may interfere with amylase and lipase analysis

A

Opiates

48
Q

Substance (other than substrate) whose presence is essential for activity of an enzyme

A

Cofactor

49
Q

Water soluble end product of toxic ammonia

A

Urea

50
Q

Enzymes which catalyze the joining of specified molecules or groups by a double bond

A

Lyase

51
Q

Period when environment is adjusting a reaching equilibrium

A

Lag

Clinical Chemistry 1 (13 decks)

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