Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology and serology > quiz 3 > Flashcards

quiz 3 Flashcards

1
Q

What type of nucleic acids does Hep B have

A

DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the markers for Hep A

A

IgM anti- HAV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When testing for Hep A, if IgM is detected what does this indicate

A

current infection or recent exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When testing for Hep A, if IgG is detected what does this indicate

A

immunity; have been vaccinated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the four ACUTE serological markers

A

Anti- HAV, HbsAG, Anti-HBc, Anti- HCV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is anti- HAV directed against

A

its an IgM antibody directed against Hep A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is HBsAG

A

hep B surface antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is anti-HBc directed against

A

its an IgM antibody directed against hep B core antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is anti-HCV

A

antibody against hep C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are antibody markers for hbv

A

anti- HBc, anti- HBe, anti- HBs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

if anti- HBc is present, what does this indicate

A

current or recent acute infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is anti- HBe

A

antibodies directed against HBeAG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

If anti- HBe is present, what does this indicate

A

recovery from hbv

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

If HBeAG is present (the antigen), what does this indicate

A

pt is highly infectious; marker of active viral replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What markers are on hep b virus surface and in core

A

core protein, b-e protein, surface antigen (HBsAG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does presence of HBsAG indicate

A

marker for active hbv infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

If positive for HbsAG and anti- HBc IgM, what is the dx

A

acute hep b infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is first hbv marker to appear

A

core protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is second hbv marker to appear

A

anti- HBc (against core protein)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is third hbv marker to appear

A

HBsAG

21
Q

What is fourth hbv marker to appear

A

anti- HBs IgG

22
Q

When is an individual considered chronically infected with hbv

A

if HBsAG is present for more than six months

23
Q

Which three markers determine the stage of chronic infection

A

HBsAG, HBeAG, anti-HBc IgG

24
Q

Testing which markers determines hbv immunity

A

anti- HBs (antibody against surface antigen)

25
Q

What is hbv vaccine contain

A

surface antigen

26
Q

Which protein complex is anchored into HIV envelope

A

gp120/gp41

27
Q

Which proteins surround the HIV genome

A

p24 and p17

28
Q

Which three enzymes are in the HIV nucleocapsid

A

protease, reverse transcriptase, integrase

29
Q

Which three encoding genes are in the HIV genome

A

gag, pol, env

30
Q

Which co-receptors are required for gp120 to attach to CD4 on host, allowing virus to enter

A

CXCR4 and CCR5

31
Q

Asymptomatic stage of HIV

A

flu like symptoms, lymphadenopathy. test for p24

32
Q

Seroconversion stage of HIV

A

detectable antibodies from 2 weeks - 6 months

33
Q

Latent phase of HIV

A

lasts up to 10 yrs, CD4 destroyed slowly, viral RNA and Ab detected

34
Q

Clinical AIDS stage

A

serious infections

35
Q

What concentration of CD4 T cells is indicative of HIV

A

< 200 cells/uL

36
Q

What is done for HIV screening test and what is detected

A

ELISA, detects antibodies against gp120

37
Q

What is confirmatory test for HIV and what is detected

A

Western blot, detects IgG to HIV

38
Q

Four types of tests used in dx and monitoring of HIV

A

CD4 T cell enumeration (see if < 200 cells/ uL)
HIV antibody detection (ELISA and western blot)
HIV antigen detection (early stages)
HIV nucleic acid detection (RT-PCR)

39
Q

What is principle of ELISA screening for HIV

A

detects HIV antibody in serum to vital antigens coated onto a solid support

40
Q

What is principle of western blot

A

separated HIV antigens, p24, gp41, and gp120/160 on western blot media is treated with pt serum; at least two of the antigens should be detected to call result positive

41
Q

What is reagin

A

antibody against cardiolipin; non treponemal antibody

42
Q

What are nontreponemal tests for syphilis

A

VDRL, RPR

43
Q

What do VDRL and RPR detect

A

reagin

44
Q

What reaction occurs in VDRL and RPR

A

flocculation- precipitation that produces clumping of fine cardiolipin particles

45
Q

What are confirmatory tests for syphilis

A

most common is FTA-ABS (fluorescent treponemal absorption)– detects antibodies against T. pallidum

46
Q

Does VDRL display sensitivity in latent patients

A

no

47
Q

How is lyme dx

A

ELISA; if positive confirm with western blot

48
Q

Which band should be present to identify lyme

A

41 kD

Immunology and serology (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions