quiz 2 review Flashcards
Ellagic acid or kaolin in the APTT reagent provide
maximum contact activation
Which of the following are natural controls of fibrinolysis?
alpha 2 antiplasmin
alpha 2 macroglobulin
A person who has a Protein S deficiency would tend toward:
clotting
Factor XIIa role
activates plasminogen to plasmin
Factor VIIIa role
complexes with V, X to activate X to Xa
Factor XIIIa role
stabilizes the fibrin clot
Factor VIIa role
activates X to Xa
Factor IIa role
converts fibrinogen to fibrin monomer
A patient who has a Factor IX activity level of <1% has which of the following disorders?
Hemophilia B
If an individual has a normal PT, a prolonged APTT, a normal TT, 1:1 with normal plasma for APTT
= correction; 1:1 with saline for APTT = no correction, what is the most likely reason?
Factor XI deficiency
Streptokinase and urokinase are:
medications that activate plasminogen
Lupus anticoagulant (inhibitor):
may cause a prolonged APTT
is an antibody to phospholipid
Protein S:
is a cofactor for Protein C
is vitamin K dependent
Causes of an increased thrombin time:
dysfibrinogenemia
heparin in the sample
The INR (International Normalized Ratio):
is usually reported with the PT
standardizes testing for different PT reagents
is calculated using the ISI (International Sensitivity Index) of the PT reagent
is especially important for patients being treated with coumadin
An abnormally high amount of D-dimer indicates:
increased fibrinolysis
increased clotting
PAI (I) - Plasminogen activator inhibitor I:
inhibits fibrinolysis
Coagulation proteins are made primarily:
in the liver
Protein C and Protein S:
are inhibitors of coagulation
act on Factors Va and VIIIa
How does Vitamin K participate in the coagulation process?
it activates Factors II, VII, IX and X by carboxylating them
In a patient with disseminated intravascular coagulation (DIC), one can expect:
prolonged PT, APTT, TT
decreased platelet count
Which coagulation factors are consumed in the clotting process?
I and II
V and VIII
How is Factor XII activated?
by contact with negatively charged surfaces
Which factor circulates in combination with Von Willebrand’s factor?
Factor VIII
The intrinsic pathway factors are evaluated by the:
APTT
Antithrombin has a major role in _____________________, and its effect is potentiated
by________________.
clot prevention; heparin
Thrombin has an important role in clot formation, but also an important role in preventing clot formation by:
it binds to thrombomodulin and activates Protein C
it stimulates the release of tissue plasminogen activator
A patient presents with the following test data. Select the choice(s) that would be consistent with the
results.
PT = 12 sec
APTT = 33 sec
TT = 16 sec
normal
Testing methods for D-dimers:
latex agglutination
immunoassay using sandwich technique
Which of the following are principles of clot detection used in coagulation instruments?
change in optical density electromechanical
Fibrin monomers:
are the product of the action of thrombin on fibrinogen
are increased in DIC and liver disease
What is the Laurel Rocket electrophoretic technique usually used to detect?
coagulation factor antigenic amount
The PIVKA test is used mainly for:
detection of Vitamin K deficiency
