Coagulase Cascade Flashcards
Intrinsic pathway
XII—->XIa
|
XI—–>XIa
| Ca(++)
IX—–>IX+ VIIa & PL + Ca(++)
Extrinsic pathway (coagulation cascade)
TF+ VII
|
Ca(++) + VIIa
Common pathway (coagulation cascade)
X
|
(+Intrinsic complex) Xa (+extrinsic complex)
|
Xa
|
Xa+Va & PL + Ca(++)
|
Prothrombin–>thrombin—>XII—->XIIa
Fibrinogen+thrombin—>fibrin+XIIa—> crosslinked fibrin
Intrinsic Xase complex
IX+ VIIIa
PL+ Ca(++)
Extrinsic Xase complex
Tissue factor
Ca(++) + VIIa
Prothrombinase complex
Xa + Va
PL + Ca(++)
I (coagulation cascade)
Fibrinogen
II (coagulation cascade)
Prothrombin
III (coagulation cascade)
Tissue factor
IV (coagulation cascade)
Calcium
V (coagulation cascade)
Proaccelerin
VII (coagulation cascade)
Proconvertin, stable factor
VIII (coagulation cascade)
Antihemophilic factor
VWF (coagulation cascade)
Von Willebrand factor
IX (coagulation cascade)
Plasma thromboplastin component
X (coagulation cascade)
Stuart factor
XI (coagulation cascade)
Plasma thromboplastin antecedent
XII (coagulation cascade)
Haegeman factor
XIII (coagulation cascade)
Fibrin stabilizing factor
HK (coagulation cascade)
Fitzgerald factor, Williams factor, Flaujeac factor
PK (coagulation cascade)
Fletcher factor
PL (coagulation cascade)
Platelet phospholipid
TF (coagulation cascade)
Tissue factor
Prothrombin group of coagulation
Factors: 2, 7, 9, 10
Vit K dependent
Fibrinogen group of coagulation
Factors: 1, 2, 5, 8, 13
Not found in serum
Contact group of coagulation
Factors: 11, 12, PK (prekallekrein), HK (high molecular weight kininogen)
Activate intrinsic pathway
Cofactors of coagulation
Factors 5, 8
Cofactors of 10, 9
Substrates of coagulation
Fibrinogen
Enzymes of coagulation
Factors: 7, 9, 10, 11, 12
Cleave arginine/lysine
Factor 13- transglutaminase activity catalyzes formation of peptide bonds btwn glutamine & lysine on fibrin making cross links in fibrin meshwork
