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HDM > Quiz 2 Practice Questions > Flashcards

Quiz 2 Practice Questions Flashcards

1
Q

Immunoglobulin light chain

A

VJ

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2
Q

TCR alpha chain

A

VJ

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3
Q

TCR beta chain

A

VDJ

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4
Q

Immunoglobulin heavy chain

A

VDJ

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5
Q

DCs vs MPs

A

Sim: phagocytes, leukocytes, tissue residents, degrade pathogens
Diff: DCs transport antigen from epithelia to draining LN to activate naive T cells

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6
Q

T cell Ag

A

8-25 AA peptide

PRIMARY structure recognized as non-self AFTER DEGRADATION

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7
Q

CD8+ T cells

A

activation -> activate B cell

kill infected cells by inducing apoptosis

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8
Q

most abundant serum Abs

A

GAM

IgG, IgA, IgM

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9
Q

Abs expressed on naive B cell

A

DM

IgD or IgM

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10
Q

somatic hypermutation

A

mutational mechanism resulting in production of abs that bind antigen w/higher affinity

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11
Q

isotype switching

A

results in change of constant region of heavy chain of abs, causing change in effector fxn and transport properties of abs

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12
Q 
Incontrasttoimmunoglobulins,alpha\betaT‐cellreceptorsrecognize epitopespresentonantigens:
A.  carbohydrate 
B.  lipid 
C.  protein 
D.  carbohydrateandlipid 
E.  carbohydrate,lipidandprotein.
A

PROTEIN

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13
Q

WhichofthefollowingcharacteristicsiscommontobothT‐cellreceptorsandimmunoglobulins?
A. SomaticrecombinationofV,DandJsegmentsisresponsibleforthediversityofantigen‐
bindingsites.
B. Somatichypermutationchangestheaffinityofantigen‐bindingsitesandcontributesto
furtherdiversification.
C. Classswitchingenablesachangeineffectorfunction.
D. Theantigenreceptoriscomposedoftwoidenticalheavychainsandtwoidenticallight
chains.
E. Carbohydrate,lipidandproteinantigensarerecognizedandstimulatearesponse.

A

SOMATIC RECOMBINATION OF VDJ INCREASES FAB DIVERSITY IN TCRS AND BCRS

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14
Q

TCR Fab

A

V alpha + V beta

Most VARIABLE domains on TCR

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15
Q

TCRs recognize…

A

PEPTIDES BOUND TO MHC

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16
Q

CD8 T cells combat…

A

INTRAcellular pathogens

17
Q

CD4 T cells combat…

A

EXTRAcellular pathogens

18
Q

CD4 Th1 cells activate…

A

Macrophages

19
Q

CD4 Th2 cells activate and are associated with

A

B cell activation

HIV infection

20
Q

MHC I peptide-binding groove

A

Alpha 1 + alpha 2

21
Q

CD4 binds ____ MHC II domain

A

Beta 2

22
Q

CD8 binds ___ MHC I domain

A

Alpha 3

23
Q

MHC I peptide processing

A

proteasome -> TAP 1/2 -> ER -> MHC I -> plasma membrane

24
Q

MHC II peptide processing

A

endocytosis -> proteases -> remove CLIP from MHC II -> peptide binds MHC II -> plasma membrane

25
Q

Peptide-binding motif

A

combo of anchor residues in peptide that are capable of binding a particular MHC haplotype

26
Q

MHC restriction

A

specificity of TCR for particular peptide/MHC complex

27
Q

Balancing selection

A

maintenance of variety of MHC isoforms in a population

28
Q

Directional selection

A

replacement of older MHC isoforms with newer variants

29
Q

Interallelic conversion

A

gene conversion b/w alleles on homologous chromosomes

30
Q

Dendrites

A

Highly elaborated finger-like processes on activated DCs upon arriving at LNs

31
Q

Immunological synapse

A

areaofcontactbetweenmembranesofaTcellandanantigen‐presentingcellwherea
clusteringofprotein–proteininteractionsoccur

32
Q

Th2 cytokines differentiate…

A

B cells

33
Q

T cell prolif induced by…

A

IL-2 binding of HIGH affinity receptor -> T cell prolif of activated T cells

34
Q

IFNg transcr factor for which cell

A

T-bet
CD4 Th1 cell

FOR MY MEMORY: I F’n betcha won!

35
Q

IL-4 transcr factor for which cell

A

GATA-3
CD4 Th2 cell

FOR MY MEMORY: 2345, 13

36
Q

Cytokine receptors associated w/…

A

JAK=cytoplasmic protein kinase

STAT=transcription factor

37
Q

CD8 T cells make…

A

IFNg, TNFa, lymphotoxin, Fas ligand

38
Q

CD4 Th2 cells make…

A

IL-4, CD40L, TGF-b, IL-10

39
Q

Signaltransducersandactivatorsoftranscription(STATs)are

A

Transcr factors (JAKs)

HDM (6 decks)

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