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HDM > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-2

A

Type 1 cytokine
Source: T cells
Receptor: CD25 (low aff/naive: bg; high aff/activ: abg)
Target: T cell prolif, Treg survival, NK prolif/activ
only affects T cells w/HIGH affinity IL-2R
blocked by TGFb
CD4 T cells activated ahead of CD8 T cells to inc IL-2 (CD4 makes more than CD8)

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2
Q

IL-3

A

Type 1 cytokine
Source: T cell
Receptor: CD123/131
Target: hematopoietic progenitors maturation

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3
Q

IL-4

A

Type 1 cytokine
Source: Th2 cells, mast cells
Receptor: CD124
Target: B cell IgE, Th2 diff, M2 activ

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4
Q

IL-5

A

Type 1 cytokine
Source: Th2 cells, mast cells
Receptor: CD125/131
Target: eosinophil activ, B cell IgA

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5
Q

IL-6

A

Type 1 cytokine
Source: macrophages
Receptor: CD126/130
Target: acute phase proteins (liver), Th17 diff w/TGFb (Treg)

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6
Q

IL-12

A

Type 1 cytokine
Source: macrophages
Receptor: CD212
Target: Th1 diff, induce Tc/NK cells to make IFNg (& IL-18)

Make IFNg

  1. M1 activ (microbial killing)
  2. B cells-> complement binding, opsonizing IgG-> phagocytosis
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7
Q

IL-13

A

Type 1 cytokine
Source: Th2
Receptor: CD213/132
Target: M2 activ, B cell IgE, epith cell mucus

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8
Q

IL-17

A

Type 1 cytokine
Source: Th17 cells
Receptor: CD217
Target: acute neutrophilic inflammation

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9
Q

IL-1

A

IL-1 Family cytokine
Source: macrophages/monocytes
Receptor: CD121/218
Target: inc temp/fever, acute phase proteins (liver)
autocrine/paracrine stimulation of CTL’s (not prolif)

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10
Q

IL-8 (chemokine)

A

Source: macrophages/mast cells (stimulated by inflammation)
Receptor: GPCR
Target: neutrophil chemotaxis (STARTS INFLAMMATORY PROCESS)
Released by initial monocyte/macrophage interaction w/microbe, attracts neutrophils, then neutrophils make LTB4 to attract more neutrophils

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11
Q

IL-15

A

Type 1 cytokine
Source: macrophages
Receptor: CD122/132
Target: NK cell activ

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12
Q

IFNg

A

Type 2 cytokine
Source: Th1 and Tc cells, NK cells
Receptor: CD119
Target: M1 activ, B cell IgG

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13
Q

IL-10

A

Type 2 cytokine
Source: macrophages (Treg cells)
Receptor: CD210
Target: anti-inflam, self-tolerance

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14
Q

TGFb

A

Source: Treg cells
Target: fibrotic healing, B cell IgA (BAFF, APRIL), Th17 diff (w/IL-6), inh B/T cell activ, inh MP/NK
keloid scar

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15
Q

TNFb

A

lymphotoxin

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HDM (6 decks)

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