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Systemic Pharmacology II > Quiz 2 Material > Flashcards

Quiz 2 Material Flashcards

1
Q

Haloperidol

A

First Generation Antipsychotic: D2 antagonist (effects on movement - extrapyramidal side effects)

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2
Q

Estazolam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

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3
Q

Paroxetine

A

Selective Serotonin Reuptake Inhibitors (SSRIs): Block the reuptake of 5-HT (serotonin) = highly selective

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4
Q

Zolpidem

A

Other Hypnotic Agents (“Benzo-like”): High affinity for the benzodiazepine binding site of GABA receptors (mimicing the effects of Benzodiazepines but with shorter durations of action)

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5
Q

Naltrexone

A

Treatment of Alcohol Dependence: Long acting opiate antagonist

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6
Q

Pentobarbital

A

Barbiturates: Bind to barbiturate receptor that increase the affinity of GABA for its receptor

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7
Q

Escitalopram

A

Selective Serotonin Reuptake Inhibitors (SSRIs): Block the reuptake of 5-HT (serotonin) = highly selective

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8
Q

Clomipramine

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

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9
Q

Zaleplon

A

Other Hypnotic Agents (“Benzo-like”): High affinity for the benzodiazepine binding site of GABA receptors (mimicing the effects of Benzodiazepines but with shorter durations of action)

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10
Q

Imipramine

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

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11
Q

Eszopiclone

A

Other Hypnotic Agents (“Benzo-like”): High affinity for the benzodiazepine binding site of GABA receptors (mimicing the effects of Benzodiazepines but with shorter durations of action)

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12
Q

Secobarbital

A

Barbiturates: Bind to barbiturate receptor that increase the affinity of GABA for its receptor

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13
Q

Carbamazepine

A

Drugs used to treat Mania and Bipolar Disorder

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14
Q

Midazolem

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

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15
Q

Doxepin

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

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16
Q

Desipramine

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

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17
Q

Sertraline

A

Selective Serotonin Reuptake Inhibitors (SSRIs): Block the reuptake of 5-HT (serotonin) = highly selective

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18
Q

Duloxetine

A

Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs): Block the reuptake of NE and 5-HT (serotonin) (and more effective if pain is experienced along with depression)

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19
Q

Ziprasidone

A

Second Generation Antipsychotic: Antagonist with high affinity for D2 but also D3, D4, and 5-HT receptors (does NOT have effects on movement)

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20
Q

Tranylcypromine

A

Monoamine Oxidase Inhibitors (MAOIs): Inhibit metabolism of NE, 5-HT(serotonin), and dopamine (and increasing the effectiveness of synaptic transmission by increasing the amount of transmitter replaced per action potential)

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21
Q

Phenobarbital

A

Barbiturates: Bind to barbiturate receptor that increase the affinity of GABA for its receptor

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22
Q

Chlorpromazine

A

First Generation Antipsychotic: D2 antagonist (effects on movement - extrapyramidal side effects)

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23
Q

Citalopram

A

Selective Serotonin Reuptake Inhibitors (SSRIs): Block the reuptake of 5-HT (serotonin) = highly selective

24
Q

Diazepam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

25
Q

Risperidone

A

Second Generation Antipsychotic: Antagonist with high affinity for D2 but also D3, D4, and 5-HT receptors (does NOT have effects on movement)

26
Q

Temazepam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

27
Q

Aripiprazole

A

Second Generation Antipsychotic: Antagonist with high affinity for D2 but also D3, D4, and 5-HT receptors (does NOT have effects on movement)

28
Q

Amitriptyline

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

29
Q

Flumazenil

A

Benzodiazepines Antagonist: Antagonist/block the benzodiazepine binding site

30
Q

Alprazolam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

31
Q

Clozapine

A

Second Generation Antipsychotic: Antagonist with high affinity for D2 but also D3, D4, and 5-HT receptors (does NOT have effects on movement)

32
Q

Clorazepam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

33
Q

Nortriptyline

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

34
Q

Bupropion

A

Atypical Antidepressants: Weak dopamine and NE reuptake inhibitor (also help decrease craving and withdrawal symptoms for nicotine)

35
Q

Buspirone

A

Other Anxiolytic Drug: Serotonin receptor agonist (can treat anxiety but can’t induce sedation)

36
Q

Valprioc acid

A

Drugs used to treat Mania and Bipolar Disorder

37
Q

Fluphenazine

A

First Generation Antipsychotic: D2 antagonist (effects on movement - extrapyramidal side effects)

38
Q

Mirtazapine

A

Atypical Antidepressants: Enhances serotonin and NE neurotransmission (block presynaptic alpha-2 receptors) and potent antihistamine activity (sedative)

39
Q

Thiothixene

A

First Generation Antipsychotic: D2 antagonist (effects on movement - extrapyramidal side effects)

40
Q

Trazodone

A

Atypical Antidepressants: Weak inhibitor of serotonin reuptake and potent antihistamine activity (sedative)

41
Q

Nefazodone

A

Atypical Antidepressants: Weak inhibitor of serotonin reuptake and potent antihistamine activity (sedative)

42
Q

Chlordiazepoxide

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

43
Q

Selegiline

A

Monoamine Oxidase Inhibitors (MAOIs): Inhibit metabolism of NE, 5-HT(serotonin), and dopamine (and increasing the effectiveness of synaptic transmission by increasing the amount of transmitter replaced per action potential)

44
Q

Ramelteon

A

Melatonin Receptor Agonist

45
Q

Venlafaxine

A

Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs): Block the reuptake of NE and 5-HT (serotonin) (and more effective if pain is experienced along with depression)

46
Q

Phenelzine

A

Monoamine Oxidase Inhibitors (MAOIs): Inhibit metabolism of NE, 5-HT(serotonin), and dopamine (and increasing the effectiveness of synaptic transmission by increasing the amount of transmitter replaced per action potential)

47
Q

Triazolam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

48
Q

Quetiapine

A

Second Generation Antipsychotic: Antagonist with high affinity for D2 but also D3, D4, and 5-HT receptors (does NOT have effects on movement)

49
Q

Protriptyline

A

Tricyclic Antidepressants (TCAs): Block the reuptake of NE and 5-HT (serotonin) by inhibiting the transporter protein

50
Q

Acamprosate

A

Treatment of Alcohol Dependence: Poorly understood MOA

51
Q

Oxazepam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

52
Q

Lithium

A

Drug used to treat Mania: MOA not understood (but thought to inhibit two signal transduction pathways)

53
Q

Fluoxetine

A

Selective Serotonin Reuptake Inhibitors (SSRIs): Block the reuptake of 5-HT (serotonin) = highly selective

54
Q

Flurazepam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

55
Q

Lorazepam

A

Benzodiazepines: Bind to benzodiazepine receptor that increase the affinity of GABA for its receptor and also decrease the release of GABA

56
Q

Thioridazine

A

First Generation Antipsychotic: D2 antagonist (effects on movement - extrapyramidal side effects)

57
Q

Disulfiram

A

Treatment of Alcohol Dependence: Inhibits aldehyde dehydrogenase (causes terrible side effects so patients would avoid alcohol to prevent side effects)

Systemic Pharmacology II (5 decks)

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