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Systemic Pharmacology II > Quiz 1 Material > Flashcards

Quiz 1 Material Flashcards

1
Q

Propranolol

A

Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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2
Q

Nitroprusside

A

Parenteral Agents MOA: Causes release of NO with result of increased intracellular cGMP and dilates arterioles and veins

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3
Q

Amlodipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

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4
Q

Dopamine

A

Inotropes (Beta-adrenergic agonists) MOA: Cause positive inotropic effects and vasodilation; increase cAMP which activates protein kinase, and protein kinase increases calcium influx into cells

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5
Q

Acetazolamide

A

Carbonic Anhydrase Inhibitor MOA: Prevent carbonic anhydrase from catalyzing the reaction that form bicarbonate and decrease the kidney’s ability to exchange Na for H

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6
Q

Mannitol

A

Osmotic Diuretics MOA: Filtered through the glomerulus and carries water with them

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7
Q

Metoprolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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8
Q

Moexipril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

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9
Q

Isosorbide mononitrate

A

Organic Nitrates MOA: Enzyme activation of drug causes release of NO and NO combines with guanylyl cyclase causing an increase in cGMP

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10
Q

Prazosin

A

Alpha Blockers MOA: Competitive block of alpha 1 receptors to result in a relaxation of arterial and venous smooth muscle. Vasodilation decreases peripheral vascular resistance and decreases BP

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11
Q

Ethacrynic acid

A

Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl

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12
Q

Bisoprolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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13
Q

Milrinone

A

Inotropes (Phosphodiesterase inhibitors) MOA: Prevent hydrolysis of cAMP, Increase activity of calcium channel causing greater influx of Ca and also cause vasodilation

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14
Q

Enalapril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

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15
Q

Diltiazem

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

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16
Q

Methazolamide

A

Carbonic Anhydrase Inhibitor MOA: Prevent carbonic anhydrase from catalyzing the reaction that form bicarbonate and decrease the kidney’s ability to exchange Na for H

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17
Q

Acebutolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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18
Q

Fenoldopam

A

Parenteral Agents MOA: Peripheral dopamine-1 receptor agonist Relaxes mainly the renal and mesenteric arterial vessels and increases renal blood flow

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19
Q

Eprosartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

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20
Q

Hydralazine

A

Vasodilators MOA: Releases NO

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21
Q

Isosorbide dinitrate

A

Organic Nitrates MOA: Enzyme activation of drug causes release of NO and NO combines with guanylyl cyclase causing an increase in cGMP

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22
Q

Bumetanide

A

Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl

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23
Q

Esmolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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24
Q

Nitroglycerin

A

Organic Nitrates MOA: Enzyme activation of drug causes release of NO and NO combines with guanylyl cyclase causing an increase in cGMP

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25
Q

Benazepril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

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26
Q

Felodipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

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27
Q

Ranolazine

A

Sodium (NA) Channel MOA: Inhibits the late phase of the Na current, and reduces intracellular sodium and calcium overload Improves diastolic function

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28
Q

Dobutamine

A

Inotropes (Beta-adrenergic agonists) MOA: Cause positive inotropic effects and vasodilation; increase cAMP which activates protein kinase, and protein kinase increases calcium influx into cells

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29
Q

Indapamide

A

Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter

30
Q

Irbesartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

31
Q

Labetalol

A

Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

32
Q

Clonidine

A

Centrally-acting Alpha-2 Agonists MOA: Decrease sympathetic output and reduces NE release

33
Q

Azilsartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

34
Q

Trandolapril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

35
Q

Verapamil

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

36
Q

Valsartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

37
Q

Captopril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

38
Q

Telmisartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

39
Q

Nisoldopine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

40
Q

Quinapril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

41
Q

Clevidipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

42
Q

Chlorthalidone

A

Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter

43
Q

Doxazosin

A

Alpha Blockers MOA: Competitive block of alpha 1 receptors to result in a relaxation of arterial and venous smooth muscle. Vasodilation decreases peripheral vascular resistance and decreases BP

44
Q

Ramipril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

45
Q

Cilazapril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

46
Q

Atenolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

47
Q

Carvedilol

A

Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

48
Q

Nebivolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

49
Q

Nicardipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

50
Q

Metolazone

A

Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter

51
Q

Isradipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

52
Q

Epleronone

A

Potassium-Sparing Diuretics MOA: Act on the collecting tubule/duct; Blocks aldosterone receptors and prevents production of proteins that stimulate Na/K exchange sites of the collecting tubules

53
Q

Minoxidil

A

Vasodilators MOA: Hyperpolarizes smooth muscle by opening potassium channels

54
Q

Inamrione

A

Inotropes (Phosphodiesterase inhibitors) MOA: Prevent hydrolysis of cAMP, Increase activity of calcium channel causing greater influx of Ca and also cause vasodilation

55
Q

Aliskiren

A

Renin Inhibitor MOA: Directly inhibits renin

56
Q

Terazosin

A

Alpha Blockers MOA: Competitive block of alpha 1 receptors to result in a relaxation of arterial and venous smooth muscle. Vasodilation decreases peripheral vascular resistance and decreases BP

57
Q

Fosinopril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

58
Q

Spironolactone

A

Potassium-Sparing Diuretics MOA: Act on the collecting tubule/duct; Blocks aldosterone receptors and prevents production of proteins that stimulate Na/K exchange sites of the collecting tubules

59
Q

Furosemide

A

Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl

60
Q

Nifedipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

61
Q

Digoxin

A

Inotropes (Cardiac glycosides) MOA: Inhibits the ability of the monocyte to actively pump Na from the cell

62
Q

Hydrochlorothiazide (HCTZ)

A

Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter

63
Q

Lisinopril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

64
Q

Torsemide

A

Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl

65
Q

Nadolol

A

Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

66
Q

Perindopril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

67
Q

Losartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

68
Q

Olmesartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

69
Q

Methyldopa

A

Centrally-acting Alpha-2 Agonists MOA: Decrease sympathetic output and reduces NE release

70
Q

Candesartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

Systemic Pharmacology II (5 decks)

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