Quiz 2 Drugs

Question 1

Name the six major SSRIs:

Answer 1

Question 1

Name the 5 major SNRIs:

Answer 1

Question 2

Name the 4 major Tricyclic Antidepressants (TCAs):

Answer 2

Question 3

Name the 4 major atypical antidepressants:

Answer 3

Question 4

Name the 3 major MAOIs:

Answer 4

Question 5

What is the significant BBW that all antidepressants have? How long do antidepressants typically take to start working? What is unique about the time to improvement?

Answer 5

Question 6

Where do the following classes of antidepressants exert their effect:
SSRIs
SNRIs
TCAs
MAOIs

Answer 6

Question 7

What is the Monoamine Hypothesis of Mood?

Answer 7

Question 8

What is the Brain-derived Neurotrophic Factor Theory?

Answer 8

Question 9

Describe several of the important distinguishing roles of the following CNS NT:
Dopamine
5-HT
NE

Answer 9

Question 10

What are the generic and brand names of the 6 main SSRIs?

Answer 10

Question 11

What is the MoA of SSRIs?

Answer 11

Question 12

In what pregnancy category do SSRIs belong? Which SSRI is an exception to this? What are the three SSRIs with DDIs, and what is the interaction?

Answer 12

Question 13

Which SSRI is the most activating? Which is the most sedating, or anticholinergic?

Answer 13

Question 14

Which SSRI has the longest half-life? Which SSRI has the shortest half-life?

Answer 14

Question 15

Which SSRI carries a risk of QT prolongation? What doses are recommended to avoid this?

Answer 15

Question 16

Which SSRI carries the highest risk for DDI? Which carries the highest risk of diarrhea?

Answer 16

Question 17

Rank the SSRIs from most activating to most sedating:

Answer 17

Question 18

What is Discontinuation Syndrome associated with? How long can it last?

Answer 18

It is associated with abrupt withdrawal of medication.

It can last up to 2 weeks.

Question 19

What increases the risk for developing Serotonin syndrome in patients taking antidepressants?

Answer 19

Question 20

What are the generic and brand names of the 5 main SNRIs?

Answer 20

Question 21

What is the MoA of SNRIs? What are they also used for besides as antidepressants?

Answer 21

Question 22

Which SNRI has a risk of causing hypertension? Which is notable for dry mouth, drowsiness/fatigue? Which cannot be used with alcohol? Why?

Answer 22

Question 23

What are notable side effects seen with SSRIs or SNRIs?

Answer 23

Question 24

Rank the SSRIs from most *activating* to most *sedating*:

Answer 24

Question 25

What are the *generic* and *brand* names of the 6 main TCAs?

Answer 25

Question 26

What is the MoA of Tricyclic Antidepressants?

Answer 26

Question 27

What are some adverse effects of TCA use? Is there a risk for discontinuation syndrome?

Answer 27

Question 28

Why is TCA use cautioned in suicidal patients? Why should use in geriatic patients be avoided?

Answer 28

Question 29

What are several alternate uses for TCA besides in treatment of depression?

Answer 29

Question 30

What are the *generic* and *brand* names of the 4 notable atypical antidepressants?

Answer 30

Question 31

What is the MoA of **Bupriopion**? What are notable AEs? What are advantages to other antidepressants?

Answer 31

Question 32

What two drugs are 5-HT2 RA used to treat depression? What is the MoA? What are notable AEs? What is Nefazodone's BBW?

Answer 32

Note these are **rarely** used to treat depression, Trazedone especially (see dosing)

Question 33

What is the MoA of Mirtazapine? What are notable AEs? What is the notable H1 receptor effect at lower doses? What are two advantages of using Mirtazapine in tx of depression?

Answer 33

Question 34

Rank the atypical ADs from most *activating* to most *sedating*:

Answer 34

Question 35

What are the *generic* and *brand* names of the 3 notable MAOIs?

Answer 35

Question 36

What is the MoA of MAOIs?

Answer 36

Question 37

What are notable AE of MAOIs?

Answer 37

Question 38

What are notable DDIs of MAOIs?

Answer 38

Question 39

What are the MoA of Vilazodone and Vortioxetine?

Answer 39

Question 40

What is the classic treatment for **Seratonin Syndrome**? What is additionally done in severe cases?

Answer 40

Question 41

What is first-line to treat **Premenstrual dysphoric disorder**?

Answer 41