Quiz 2 Drugs Flashcards
Name the six major SSRIs:
Name the 5 major SNRIs:
Name the 4 major Tricyclic Antidepressants (TCAs):
Name the 4 major atypical antidepressants:
Name the 3 major MAOIs:
What is the significant BBW that all antidepressants have? How long do antidepressants typically take to start working? What is unique about the time to improvement?
Where do the following classes of antidepressants exert their effect:
SSRIs
SNRIs
TCAs
MAOIs
What is the Monoamine Hypothesis of Mood?
What is the Brain-derived Neurotrophic Factor Theory?
Describe several of the important distinguishing roles of the following CNS NT:
Dopamine
5-HT
NE
What are the generic and brand names of the 6 main SSRIs?
What is the MoA of SSRIs?
In what pregnancy category do SSRIs belong? Which SSRI is an exception to this? What are the three SSRIs with DDIs, and what is the interaction?
Which SSRI is the most activating? Which is the most sedating, or anticholinergic?
Which SSRI has the longest half-life? Which SSRI has the shortest half-life?
Which SSRI carries a risk of QT prolongation? What doses are recommended to avoid this?
Which SSRI carries the highest risk for DDI? Which carries the highest risk of diarrhea?
Rank the SSRIs from most activating to most sedating:
What is Discontinuation Syndrome associated with? How long can it last?
It is associated with abrupt withdrawal of medication.
It can last up to 2 weeks.
What increases the risk for developing Serotonin syndrome in patients taking antidepressants?
What are the generic and brand names of the 5 main SNRIs?
What is the MoA of SNRIs? What are they also used for besides as antidepressants?
Which SNRI has a risk of causing hypertension? Which is notable for dry mouth, drowsiness/fatigue? Which cannot be used with alcohol? Why?
What are notable side effects seen with SSRIs or SNRIs?
Rank the SSRIs from most activating to most sedating:
What are the generic and brand names of the 6 main TCAs?
What is the MoA of Tricyclic Antidepressants?
What are some adverse effects of TCA use? Is there a risk for discontinuation syndrome?
Why is TCA use cautioned in suicidal patients? Why should use in geriatic patients be avoided?
What are several alternate uses for TCA besides in treatment of depression?
What are the generic and brand names of the 4 notable atypical antidepressants?
What is the MoA of Bupriopion? What are notable AEs? What are advantages to other antidepressants?
What two drugs are 5-HT2 RA used to treat depression? What is the MoA? What are notable AEs? What is Nefazodone’s BBW?
Note these are rarely used to treat depression, Trazedone especially (see dosing)
What is the MoA of Mirtazapine? What are notable AEs? What is the notable H1 receptor effect at lower doses? What are two advantages of using Mirtazapine in tx of depression?
Rank the atypical ADs from most activating to most sedating:
What are the generic and brand names of the 3 notable MAOIs?
What is the MoA of MAOIs?
What are notable AE of MAOIs?
What are notable DDIs of MAOIs?
What are the MoA of Vilazodone and Vortioxetine?
What is the classic treatment for Seratonin Syndrome? What is additionally done in severe cases?
What is first-line to treat Premenstrual dysphoric disorder?
