Quiz 2 Flashcards
- What does botulism do at the neuromuscular junction?
a. Blocks acetylcholinesterase
- Neostigmine…
a. Inhibits cholineesterase
- Cholinergic agonist…
a. increases GI motility
- Adverse effect of cholinergic agonist..
a. diarrhea
- tubocurarine is a …
a. neuromuscular blocker
- nicotine…
a. nicotinic ganglion blocker
- Neostigmine used to treat..
a. myasthenia gravis
- Adverse effect of atropine..
a. Mydriasis
- mechanism of cholinergic agonist
?
- adverse effect of succinylcholine…
a. increase body temperature
Acetylcholine actions include…
Decrease HR & BP, increase GI motility & secretions, cause miosis
What cholinergic receptors are excitatory on the heart, smooth ms, brain & exocrine glands?
Muscarinic M1
What cholinergic receptors are inhibitory on the adrenal medulla, ganglia, and neuromuscular junctions?
Muscarinic M2
What are the adverse effects of cholinergic drugs?
Diarrhea, diaphoresis, miosis, nausea, urinary urgency
What is used in atropine overdose?
Physostigmine
What is used for Myasthenia gravis, and as an antidote for tubocurarine?
Neostigmine
Neostigmine can be reactivated by…
PAM/pralidoxime
In small doses, what are the actions of nicotine?
Stimulant: Increase HR, BP, peristalsis and secretions
In high doses, what are the actions of nicotine?
Blocker: Decreased HR, peristalsis and secretions-block ANS@nicotinic receptors
What is used during the induction of anesthesia, & during electroconvulsive shock treatment?
Succinylcholine
What are the side effects of Succinylcholine?
Malignant hypertension & post-operative muscle pain
What is used during surgery to relax skeletal muscle?
Tubocurarine
