Quiz Flashcards
As a pharmacy student, your knowledge in physical pharmacy may be useful in:
-an understanding of the basic physical chemistry necessary for the drug design.
-increasing the absorption of drug upon administration.
-the manufacture of medicines on both a small and a large scale.
-the cultivation, avoidance, and elimination of microorganisms in medicines.
-structural modification of drugs
Pharmaceutics
This requires the following:
* Understanding of the basic physical chemistry necessary for the
efficient design of dosage forms.
* The design and formulation of medicines.
* The manufacture of these medicines on both small (compound) and
large (pharmaceutical technology) scale.
* The cultivation, avoidance, and elimination of microorganisms in
medicines.
Which of the following is/are true about the scope of definition of a drug?
Vitamins may be classified as drugs.
Drug is a chemical that affects the structure or function of animal body.
Drug may be used to poison an individual.
Drug is intended for use as a device or a component, part, or accessory of a
device.
Drug is substance recognized in the Philippine pharmacopoeia.
The option that is not an answer to the question would be:
Drug is intended for use as a device or a component, part, or accessory of a device.
This statement does not correctly define a drug. A drug is typically a substance used to diagnose, treat, prevent disease, or affect the body’s structure or function, but it is not classified as a device or its component. Devices are separately regulated in healthcare.
You are a manufacturing pharmacist working in research and development department of a company. You were tasked to design a formulation with the objective of creating high-quality and efficacious dosage forms. Which of the following information is NOT a consideration formulation development?
Disease of the patients to be treated
Manufacturing capability of the company
Character and competence of the pharmacist
Physical and chemical properties of drugs and additives
None of the above
The correct answer is:
Character and competence of the pharmacist
While the pharmacist’s competence is important, it is not directly related to the technical aspects of formulation development. The focus in formulation development is on the disease being treated, the manufacturing capabilities of the company, and the physical and chemical properties of the drugs and additives used in the formulation.
Which of the following is/are type/s of physical change?
Rusting of iron
Combustion of alkane gases
Vaporization of liquid water
Neutralization between acids and bases
Coloring the hair using hydrogen peroxide
The correct answer is:
Vaporization of liquid water
This is a physical change because it involves a change in the state of matter (from liquid to gas) without altering the chemical composition of the substance.
The other options are examples of chemical changes, where new substances with different chemical compositions are formed:
Rusting of iron (formation of iron oxide)
Combustion of alkane gases (reaction with oxygen to form CO₂ and water)
Neutralization between acids and bases (formation of water and salt)
Coloring the hair using hydrogen peroxide (oxidation process that changes hair color).
Which of the following is/are example/s of intensive property?
Normality
solidification point
distance
particle size
color
The correct answers are:
Solidification point
Color
These are examples of intensive properties, which do not depend on the amount of substance present.
Normality is an extensive property (it depends on the quantity of solute in a solution).
Distance and particle size are also extensive properties (they depend on the size or extent of the material).
Intensive properties, like solidification point and color, are inherent to the substance itself, regardless of the amount.
A student from physical pharmacy class has characterized the physical properties of water drinking fountain available in school. Upon determining the boiling point, there was an apparent difference between the actual and theoretical value. This means that:
the water is impure.
the water contains microbial contamination.
it is normal, since ideal property of substance is never achieved in the actual test.
it may be due to the temperature of the working condition.
the glassware or apparatus used was able to absorb the heat during boiling.
From the previous question, the vapor pressure of sample was observed to decrease. This is due to:
the solubility of the solute with water.
the number of particles present in the sample.
vapor pressure being dependent on temperature.
chemical nature of solute present in the sample.
the identity of the particle present in the sample
what are the answers
The correct answers are:
The number of particles present in the sample.
Vapor pressure being dependent on temperature.
Chemical nature of solute present in the sample.
Which of the following statements regarding forces of attraction is/are true?
*
Knowledge of forces of attraction is important for understanding stability of drug formulation.
Substances with stronger intermolecular attractive forces have higher boiling temperatures.
For molecules to exist as aggregates in gases, liquids, and solids, intermolecular forces must exist
The stability of the interaction will change by either a decrease in attraction or an increase in repulsion
Intermolecular forces of attraction can affect the biological activity of the drug.
The correct answers are:
Knowledge of forces of attraction is important for understanding stability of drug formulation.
Substances with stronger intermolecular attractive forces have higher boiling temperatures.
For molecules to exist as aggregates in gases, liquids, and solids, intermolecular forces must exist.
The stability of the interaction will change by either a decrease in attraction or an increase in repulsion.
Intermolecular forces of attraction can affect the biological activity of the drug.
All of these statements are true, as they accurately describe the role and importance of intermolecular forces in drug formulation, physical properties like boiling point, molecular aggregation, interaction stability, and the biological activity of drugs.
What are the intermolecular forces of attraction that exist in amoxicillin
Amoxicillin, as a drug molecule, contains various functional groups that allow it to exhibit several intermolecular forces of attraction. The primary intermolecular forces in amoxicillin are:
Hydrogen bonding:
Amoxicillin has several polar groups, such as hydroxyl (–OH), amino (–NH₂), and carboxyl (–COOH), which can form hydrogen bonds with water molecules, other amoxicillin molecules, or biological targets like proteins.
Dipole-dipole interactions:
The polar functional groups in amoxicillin create dipoles, leading to attractions between the partially positive and negative ends of molecules. This is common in molecules with polar covalent bonds, such as the carbonyl and amine groups in amoxicillin.
London dispersion forces (van der Waals forces):
Even though amoxicillin has polar functional groups, it also exhibits weak London dispersion forces due to the temporary dipoles that can form in its nonpolar regions, such as parts of the aromatic ring and hydrocarbon chains.
These intermolecular forces contribute to amoxicillin’s solubility, stability, and interaction with biological targets like bacterial enzymes, impacting its overall pharmacological activity.
What are the intermolecular forces of attraction that exist in cetirizine
Cetirizine, an antihistamine drug, exhibits several types of intermolecular forces due to its functional groups. The primary intermolecular forces in cetirizine are:
Hydrogen bonding:
Cetirizine contains hydroxyl (–OH) and amine (–NH) groups that can form hydrogen bonds with water molecules or other cetirizine molecules. This interaction is significant for its solubility and biological activity.
Dipole-dipole interactions:
The presence of polar functional groups, such as the amine group and the carboxyl group, creates dipole moments within the cetirizine molecule, leading to dipole-dipole attractions between cetirizine molecules or with other polar substances.
London dispersion forces (van der Waals forces):
Cetirizine also exhibits London dispersion forces due to temporary dipoles that occur in its nonpolar regions, such as the hydrophobic parts of the molecule, including the aromatic ring.
These intermolecular forces influence cetirizine’s solubility, stability, and interactions with biological targets, which are crucial for its efficacy as an antihistamine.
What are the intermolecular forces of attraction that exist in dopamine
Dopamine, a neurotransmitter, exhibits several types of intermolecular forces due to its functional groups. The primary intermolecular forces in dopamine are:
Hydrogen bonding:
Dopamine has hydroxyl groups (–OH) and an amine group (–NH₂) that can form hydrogen bonds. The hydroxyl groups on the benzene ring and the amine group can interact with water molecules or other dopamine molecules through hydrogen bonding.
Dipole-dipole interactions:
Dopamine contains polar functional groups, such as the hydroxyl and amine groups, which create dipoles. These dipoles lead to dipole-dipole attractions between dopamine molecules or with other polar substances.
London dispersion forces (van der Waals forces):
The aromatic benzene ring in dopamine contributes to London dispersion forces. These are weak interactions that arise from temporary dipoles induced in nonpolar regions of the molecule.
Dopamine does not typically engage in ion-dipole interactions, as it is a neutral molecule and does not have ionic groups.
What are the intermolecular forces of attraction that exist in MBS
Medroxyprogesterone acetate (MPA) does not typically refer to “MBS,” so I’ll assume you meant Methylbenzene sulfonate (MBS), a common chemical compound. For Methylbenzene sulfonate, the primary intermolecular forces are:
Dipole-dipole interactions:
Methylbenzene sulfonate contains a sulfonate group (–SO₃⁻) which is polar. This creates dipole-dipole interactions between molecules.
Hydrogen bonding:
The sulfonate group has the ability to act as a hydrogen bond acceptor. However, it does not have hydrogen bond donors, so hydrogen bonding will be less prominent compared to compounds with hydroxyl or amino groups.
London dispersion forces (van der Waals forces):
The benzene ring in Methylbenzene sulfonate contributes to London dispersion forces. These are weak interactions due to temporary dipoles in the nonpolar regions of the molecule.
What are the intermolecular forces of attraction that exist in simvastatin
Simvastatin, a statin drug used to lower cholesterol levels, exhibits several types of intermolecular forces due to its functional groups. The primary intermolecular forces in simvastatin are:
Hydrogen bonding:
Simvastatin contains hydroxyl groups (–OH) and a lactone ring, which can participate in hydrogen bonding. The hydroxyl groups can act as hydrogen bond donors and acceptors, forming hydrogen bonds with water molecules or other simvastatin molecules.
Dipole-dipole interactions:
The presence of polar functional groups, such as the carboxyl group in the lactone ring, creates dipoles within the molecule. These dipoles lead to dipole-dipole interactions between simvastatin molecules or with other polar substances.
London dispersion forces (van der Waals forces):
The hydrocarbon portions of simvastatin, including the alkyl chains and aromatic ring, contribute to London dispersion forces. These forces arise from temporary dipoles in nonpolar regions of the molecule.
Simvastatin does not typically engage in ion-dipole interactions, as it is a neutral molecule without ionic groups. The predominant intermolecular forces in simvastatin are hydrogen bonding, dipole-dipole interactions, and London dispersion forces.
Which of the following statements is/are TRUE regarding polar and non-polar covalent bonds?
The physical properties of substances are also affected by their polarities.
A covalent bond that has an equal sharing of electrons is called a nonpolar covalent bond.
If there is no difference in the electronegativities of atoms, this means that a molecule is nonpolar.
The polarity of a covalent bond can be judged by determining the difference in the electronegativities of the two atoms making the bond.
A nonpolar molecule is easily absorbed in the body than a polar molecule
The true statements regarding polar and non-polar covalent bonds are:
The physical properties of substances are also affected by their polarities.
True. The physical properties such as boiling and melting points, solubility, and interaction with other substances are influenced by the polarity of molecules.
A covalent bond that has an equal sharing of electrons is called a nonpolar covalent bond.
True. In a nonpolar covalent bond, electrons are shared equally between the two atoms, typically seen in diatomic molecules of the same element (e.g., H₂, O₂).
The polarity of a covalent bond can be judged by determining the difference in the electronegativities of the two atoms making the bond.
True. The difference in electronegativity between the two atoms helps determine the degree of polarity in the bond. A larger difference indicates a more polar bond.
The statements:
If there is no difference in the electronegativities of atoms, this means that a molecule is nonpolar.
This is generally true for diatomic molecules of the same element, but not necessarily for all molecules. For example, a molecule with multiple polar bonds could still be nonpolar overall if its geometry is symmetrical.
A nonpolar molecule is easily absorbed in the body than a polar molecule.
This statement is not universally true. The absorption of a molecule in the body depends on various factors, including its size, solubility, and how it interacts with biological membranes. Generally, nonpolar molecules may more easily diffuse through lipid membranes, while polar molecules might require specific transport mechanisms. However, the ease of absorption is context-dependent and cannot be generalized for all cases.
so are all the statements true?
ChatGPT said:
ChatGPT
No, not all the statements are true. Here’s a clarification:
The physical properties of substances are also affected by their polarities.
True.
A covalent bond that has an equal sharing of electrons is called a nonpolar covalent bond.
True.
If there is no difference in the electronegativities of atoms, this means that a molecule is nonpolar.
This statement is generally true for diatomic molecules of the same element but not necessarily for all molecules. A molecule with multiple bonds might be nonpolar overall despite having polar bonds if its geometry is symmetrical.
The polarity of a covalent bond can be judged by determining the difference in the electronegativities of the two atoms making the bond.
True.
A nonpolar molecule is easily absorbed in the body than a polar molecule.
This statement is not universally true. Absorption depends on various factors, including the nature of the molecule and the environment. Nonpolar molecules might diffuse through lipid membranes more easily, but this is context-dependent.
So, statements 1, 2, 4, and 3 (with the given context) are true, while statement 5 is not universally true.
For a given substance, which of the following phase transitions should RELEASE the most energy.
Melting
Sublimation
Vaporization
Condensation
Deposition
The phase transition that releases the most energy is:
Deposition
Deposition is the process where a gas transitions directly into a solid without passing through the liquid phase. It releases a significant amount of energy because it involves both the release of latent heat from condensation and freezing.
The other processes are either energy-absorbing (endothermic) or release less energy compared to deposition:
Melting (absorbs energy)
Sublimation (absorbs energy)
Vaporization (absorbs energy)
Condensation (releases energy but less than deposition)