Quiz 11 - Hemorrhage and Exercise Flashcards
- What is the definition of Shock?
Inadequacy of blood flow which results in inadequate delivery of oxygen and nutrients throughout the body to the extent that the tissues are damaged.
- What are the compensatory mechanisms that are active in hemorrhagic shock?
- Baroreceptor reflexes
- chemoreceptor reflexes
- cerebral ischemic response
- reabsorption of tissue fluids*
- endogenous vasoconstrictor substances
- renal salt and water conservation
- In shock where is vasoconstriction most prominent?
- Cutaneous vascular bed (cool skin)
- skeletal muscle vascular bed
- splanchnic vascular bed
- Blood flow is preferentially redistributed to which body organs in shock states?
Brain and Heart
- Approximately how much fluid can be reabsorbed at the capillary level to help maintain blood volume?
1 liter fluid / hr
- What are the decompensatory mechanisms that occur in progressive shock?
- Cardiac depression
- vasomotor failure
- acidosis
- blood clotting abnormalities
- reticulo-endothelial system
- CNS depression
- Cellular deterioration
- reduced organ perfusion from stimulation of inflammatory process, clotting
- What are the positive feedback decompensatory mechanisms that are triggered by severe hypotension?
- decreased CO
- decreased Arterial pressure
- decreased O2 blood flow
- tissue hypoxia
- vasodilation
- decreased coronary perfusion
- decreased inotropy
- What occurs at the cellular level that leads to irreversible shock?
Depletion of cellular high-energy phosphate reserves (ATP)
- How much can muscle blood flow be increased during extreme exercise in the well-trained athlete?
20 fold increase when exercising vs resting
- In exercise, How does muscle contraction augment venous return?
contracting muscles help pump blood through the system along with one way valves in veins.
- What happens to blood flow in muscle tissues during exercise?
Blood flow to muscles is squeezed off or decreased during contraction.
- How does capillary recruitment help deliver oxygen to muscle tissues during exercise?
It increases surface area for diffusion also when there are multiple capillaries recruited, it shortens the distance the O2 must travel for diffusion.
- What factors facilitate oxygen unloading from hemoglobin to the tissues during exercise?
Right-ward shift of oxyhemoglobin curve
- Reduced pH from lactic acid and increased pCO2
- Increased temp
- What factors during exercise enhance blood flow at the tissue level?
??
- Increase CO
- Decrease SVR
- Increased MAP
- capillary recruitment
- rightward shift of oxyhemoglobin curve
- What are the beta-2 effects of epinephrine on skeletal muscle?
dilation of vessels so they can accept more blood and offload more oxygen