Quinolines and Quinolones Flashcards
1
Q
Skraup synthesis
A
amine and glycerol with H2SO4, PhNO2 ([O] to regain aromaticity)
2
Q
Doebner-von-miller synthesis
A
amine and a,b-unsat ketone with LA catalyst for conj addition and FeCl3 ([O])
3
Q
Combes synthesis
A
amine and 1,3-diketone uses imine formation
4
Q
A