Isoquinolines Flashcards
1
Q
biosynthesis
A
using amino acid L-tyrosine
2
Q
lab synthesis
A
phenylethylamine and 1C source or ethylamino fragments and benzylic E+
3
Q
Bischler-Napieralski synthesis
A
amine and acid chloride with NEt3
4
Q
Pictet-Grams synthesis
A
benzyl ketone and acid chloride with NEt3, avoids oxidation step then Na-Hg to reduce benzyl ketone to alcohol
5
Q
Picter-Spingler synthesis
A
amine and aldehyde and EDG to help cyclisation
6
Q
Pomeranz-fritsch synthesis
A
aldehyde and amine-acetal then eliminate EtOH to get to isoquinoline
7
Q
A
