questions Moldx Flashcards

1
Q

Retinoblastoma gene mutations:

A

Can be hereditary or non-hereditary caused by mutations in the RB1 tumor suppressor gene. Autosomal dominant inheritance or one mutation and another mutation is acquired in the retinal cells in early childhood. Greatly increases the risk of developing cancer of the eye.

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2
Q

Mutations in these genes are associated with hereditary colon cancer

A

Lynch Syndrome is caused by mutations in MLH1, MSH2, MSH6, PMS2, and EPCAM.

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3
Q

Mutations associated with lung cancer

A

EGFR and KRAS mutations render them constitutively active, signaling cell proliferation

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4
Q

EGFR

A
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5
Q

MLH1, MSH2, MSH6 are

A
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6
Q

large and small subunits of Ribosome

A
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7
Q

rRNA

A
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8
Q

Nonsense and exon skipping

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9
Q

RAS mutations

A
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10
Q

exonuclease and endonuclease

A
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11
Q

telocentric

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12
Q

MSI

A
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13
Q

fragile X

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14
Q

Huntington disease

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15
Q

C an N terminus

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16
Q

tata box

A
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17
Q

how to identify ras mutations

A
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18
Q

muscular distropy

A
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19
Q

CFTR

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20
Q

Angelman vs Prader-willi

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21
Q

hplc

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22
Q

allelic discrimination primes gc clamp

A
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23
Q

retrotranposon

A
24
Q

HIV significant log change

A
25
Q

HCV testing

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26
Q

Gating in flow cytomerty

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27
Q

Sensitivity, specificity PPV, NPV

A
28
Q

Calculate number of amplicons present after 40 cycles 1000 target

A
29
Q

ribosomal RNA

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30
Q

15-17 tranlocation

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31
Q

Add what to GC rich regions to sequence

A
32
Q

Centormere is rich in which bases

A
33
Q

NGS and the number of reference bps?

A
34
Q

TMA

A
35
Q

HCA

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36
Q

PGXm sensitive drugs

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37
Q

heterogeneity

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38
Q

fold difference delta CT

A
39
Q

how many employees to accommodate a disabled person

A
40
Q

pregnant woman is exposed to a chemical at work, what to do?

A
41
Q

Someone died how long to notify osha

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42
Q

what chemicals do each class of the fire extinguishers contain

A
43
Q

Z score

A
44
Q

SD

A
45
Q

Who gets employee medical records if lab goes bancrupt

A
46
Q

sealed-bid pricing

A
47
Q

Medicare parts

A
48
Q

ICD-10 procedural codes

A
49
Q

Latent error

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50
Q

most errors happen in what phase of testing?

A
51
Q

Licensure

A
52
Q

RCF and rpm weight, radius…

A
53
Q

serial dilution

A
54
Q

hazarous material applies to what substances

A
55
Q

packaging and shipping

A
56
Q

referral testing

A
57
Q

Who must train an employee in bloodborne pathogens? How long after hired

A