questions Moldx Flashcards

1
Q

Retinoblastoma gene mutations:

A

Can be hereditary or non-hereditary caused by mutations in the RB1 tumor suppressor gene. Autosomal dominant inheritance or one mutation and another mutation is acquired in the retinal cells in early childhood. Greatly increases the risk of developing cancer of the eye.

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2
Q

Mutations in these genes are associated with hereditary colon cancer

A

Lynch Syndrome is caused by mutations in MLH1, MSH2, MSH6, PMS2, and EPCAM.

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3
Q

Mutations associated with lung cancer

A

EGFR and KRAS mutations render them constitutively active, signaling cell proliferation

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4
Q

EGFR

A
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5
Q

MLH1, MSH2, MSH6 are

A
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6
Q

large and small subunits of Ribosome

A
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7
Q

rRNA

A
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8
Q

Nonsense and exon skipping

A
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9
Q

RAS mutations

A
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10
Q

exonuclease and endonuclease

A
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11
Q

telocentric

A
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12
Q

MSI

A
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13
Q

fragile X

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14
Q

Huntington disease

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15
Q

C an N terminus

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16
Q

tata box

A
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17
Q

how to identify ras mutations

A
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18
Q

muscular distropy

A
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19
Q

CFTR

A
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20
Q

Angelman vs Prader-willi

A
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21
Q

hplc

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22
Q

allelic discrimination primes gc clamp

A
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23
Q

retrotranposon

24
Q

HIV significant log change

25
HCV testing
26
Gating in flow cytomerty
27
Sensitivity, specificity PPV, NPV
28
Calculate number of amplicons present after 40 cycles 1000 target
29
ribosomal RNA
30
15-17 tranlocation
31
Add what to GC rich regions to sequence
32
Centormere is rich in which bases
33
NGS and the number of reference bps?
34
TMA
35
HCA
36
PGXm sensitive drugs
37
heterogeneity
38
fold difference delta CT
39
how many employees to accommodate a disabled person
40
pregnant woman is exposed to a chemical at work, what to do?
41
Someone died how long to notify osha
42
what chemicals do each class of the fire extinguishers contain
43
Z score
44
SD
45
Who gets employee medical records if lab goes bancrupt
46
sealed-bid pricing
47
Medicare parts
48
ICD-10 procedural codes
49
Latent error
50
most errors happen in what phase of testing?
51
Licensure
52
RCF and rpm weight, radius...
53
serial dilution
54
hazarous material applies to what substances
55
packaging and shipping
56
referral testing
57
Who must train an employee in bloodborne pathogens? How long after hired