questions from sheets

Question 1

the response to a drug is proportional to

Answer 1

the number of receptors activated by the drugs

Question 2

the process of cellular desenstiation to a drug can take only minutes (T/F)

Answer 2

true

Question 3

following long-term treatment with a receptor antagonist the likely response of the cell is to:
(A) increase the production of receptors (upregulation)
(B) decrease the production of receptors (downregulation)
(C) not change its receptor populaltion

Answer 3

(A)

Question 4

is the term EC50 use to describe potency or efficacy

Answer 4

potency

Question 5

partial agonists do not bind to the active site of the receptor (T/F)

Answer 5

False

Question 6

define the term intristic activity

Answer 6

is the maximum activity/ effect that a receptor can have in response to a agonist, max is 1

Question 7

name four different drug routes of administration and type of drug that goes that route

Answer 7

topical steroid - eczema cream
intramuscular - testoreone
nasal - cocaine
intravenous - lidocaine

Question 8

explain what the latent period

Answer 8

the latent period is the time after administration and before the drug starts to work

Question 9

name two factors that affect the rate of absorption

Answer 9

structure of the drug

route of administration

Question 10

describe four fates of a free drug in the circulation

Answer 10

taken up by the receptors
excreted
affected/ metabolised by the liver enzymes
absorbed by the tissue

Question 11

all drugs that are taken by mouth are absorbed into the blood stream (T/F)

Answer 11

false needs to get thorugh barrer

Question 12

list two ways for drug elimination

Answer 12

excretion

hair, sweat

Question 13

why would growth promoters be used in animal production

Answer 13

fat decrease/ muscle increase
gorw/ age quicker
need less food

Question 14

list two pharmacological properties of diethyl stilboestrol (DES) that made it unsuitable as a growth promoter and describe adverse effects in human

Answer 14

lipid-soluble, retained in the meat, caused boobs and cancer

Question 15

growth hormone is an anolbic steroid (T/F)

Answer 15

true

Question 16

clenbuterol increases muscle endurance (T/F)

Answer 16

false

Question 17

all drugs of abuse have medical uses (T/F)
all drugs of abuse are illegal (T/F)
all drugs of abuse lead to dependence

Answer 17

all are false

Question 18

tolerance, dependence and withdrawl are…

Answer 18

tolerance - needs to give an increasing dose of drug to achieve the same response over time
withdrawal - symptoms observed when the body adapts to the presence of a drug and that drug is removed
dependence - physical need or psychological craving