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Oncology RIA > questions > Flashcards

questions Flashcards

1
Q

anti androgen commonly used in prostate cancer

A

Bicalutamide

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2
Q

medication used for hypercalcaemia, bone pain and was used to prevent skeletal related events prior to introduction of denosumab

A

Bisphosphonates e.g. zoledronic acid

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3
Q

kyphoplasty; injecting cement into collapsed vertebral body to help with pain control

A

vertebroplasty

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4
Q

important side effect of denosumab

A

osteonecrosis of jaw

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5
Q

how does immunotherapy in melanoma work

A

targeting signalling proteins that allow cancer cells to hide from the immune system

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6
Q

recognised toxicity adverse effects seen with immunotherapy?

A
  • endocrinopathy
  • diarrhoea
  • hepatitis
  • skin rash
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7
Q

chemotherapy is typically dosed according to?

A

body surface area

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8
Q

approximate 5 year progression free survival for patientd with Hodgkins lymphoma?

A

90%

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9
Q

what trial phase; aiming to assess the side effects of the drug and what dose should be used?

A

1

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10
Q

cytotoxic chemotherapy drug commonly used in hodgkins is cardiotoxic in 10-30% recipients

A

doxorubicin

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11
Q

chemotherapy agent associated with cisplatin?

A

hypomagnesaemia

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12
Q

chemotherapy agent that can cause peripheral neuropathy?

A

vincristine

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13
Q

urine hesitany devlop secondary to bladder atony with what chemotherapy agent?

A

vincristine

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14
Q

Raised AFP ?

A

Liver cancer

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15
Q

Ca 19-9

A

pancreatic cancer

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16
Q

raised B HCG & raised AFP

A

non seminomatous testicular cancer

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17
Q

inheritance of gardners syndrome variant of familai adenomatous polpyposis

A

autosomal dominant

18
Q

gardners syndrome variant of familai adenomatous polpyposis due to mutation in what gene?

A

mutation in APC gene

19
Q

lung fibrosis is a side effect of this chemotherapy agent

A

bleomycin

20
Q

cyclophosphamide side effect?

A

haemorrhagic cystitis

21
Q

adverse effects of methotrexate>

A
  • mucositis
  • lung fibrosis
  • liver fibrosis
    myelosuppression
22
Q

what drug may cause cardiomyopathy

A

doxorubicin

23
Q

pathological factures

A

vertebral wedge fractures & focal sclerotic bony lesions

24
Q

CA 15-3 is a tumour marker for what?

A

breast cancer

25
Q

calcitonin is a tumour marker for?

A

medullary thyroid cancer

26
Q

immediate treatment for neoplastic spinal cord compression suspected?

A

high dose oral dexamthasonea

27
Q

what is the pattern of reflexes in spinal cord compression

A

Tendon reflexes tend to be increased below the level of the lesion and absent at the level of the lesion

28
Q

HNPCC/Lynch syndrome increases your risk of developing which cancers? (2)

A
  • colorectal cancer

- endometrial cancer

29
Q

tumour marker for ovarian cancer?

A

Ca 125

30
Q

inheritance of Lynch syndrome/HNPCC

A

autosomal dominant

31
Q

where is mutation of APC gene located

A

Chromosome 5

32
Q

kartagener’s syndrome & sinusitis?

A

recurrent episodes of sinusitis because of immotile cilia syndrome

33
Q

which gene is located with prostate cancer in men?

A

BRCA 2

34
Q

what do all individuals with MEN 2 have?

A

medullary carcinoma of thyroid

35
Q

most common lung cancer in non smokers

A

adenocarcinoma

and is peripherally located

36
Q

domperidone mechanism?

A

dopamine D2 antagonist

37
Q

mechanism of ondansetron

A

5HT3 receptor antagonist

38
Q

tumour marker in colorectal cancer

A

CEA

39
Q

what is Bombesin a tumour marker for?

A
  • small cell lung cancer - gastric cnace r

- neuroblastoma

40
Q

what is S-100 a tumour marker for?

A
  • melanoma

- schwannomas

41
Q

2 markers for testicular teratomas?

A
  • AFP

- B HCG

Oncology RIA (7 decks)

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