questions Flashcards
anti androgen commonly used in prostate cancer
Bicalutamide
medication used for hypercalcaemia, bone pain and was used to prevent skeletal related events prior to introduction of denosumab
Bisphosphonates e.g. zoledronic acid
kyphoplasty; injecting cement into collapsed vertebral body to help with pain control
vertebroplasty
important side effect of denosumab
osteonecrosis of jaw
how does immunotherapy in melanoma work
targeting signalling proteins that allow cancer cells to hide from the immune system
recognised toxicity adverse effects seen with immunotherapy?
- endocrinopathy
- diarrhoea
- hepatitis
- skin rash
chemotherapy is typically dosed according to?
body surface area
approximate 5 year progression free survival for patientd with Hodgkins lymphoma?
90%
what trial phase; aiming to assess the side effects of the drug and what dose should be used?
1
cytotoxic chemotherapy drug commonly used in hodgkins is cardiotoxic in 10-30% recipients
doxorubicin
chemotherapy agent associated with cisplatin?
hypomagnesaemia
chemotherapy agent that can cause peripheral neuropathy?
vincristine
urine hesitany devlop secondary to bladder atony with what chemotherapy agent?
vincristine
Raised AFP ?
Liver cancer
Ca 19-9
pancreatic cancer
raised B HCG & raised AFP
non seminomatous testicular cancer
inheritance of gardners syndrome variant of familai adenomatous polpyposis
autosomal dominant
gardners syndrome variant of familai adenomatous polpyposis due to mutation in what gene?
mutation in APC gene
lung fibrosis is a side effect of this chemotherapy agent
bleomycin
cyclophosphamide side effect?
haemorrhagic cystitis
adverse effects of methotrexate>
- mucositis
- lung fibrosis
- liver fibrosis
myelosuppression
what drug may cause cardiomyopathy
doxorubicin
pathological factures
vertebral wedge fractures & focal sclerotic bony lesions
CA 15-3 is a tumour marker for what?
breast cancer
