Cervical cancer Flashcards
70% of cervical cancers are caused by which HPV
16 + 18
HPV 6 + 11 responsible for ?
genital warts
HPV vaccine covers for____-
16, 18, 6, 11
most common cancer in women under 35
cervical cancer
vaccine is offered to who
girls at age 12-13
catch up available up to 18 years of age
how is the vaccine given
series of 2 injections; spaced at least 6 months apart
however if offered older than 15; require 3 injections with the second being given at least a month after the first
what is the cervical screening offered
every 3 years between 25 and 49 years
every 5 years between 50 and 64 years
what is brachytherapy
uses a radioactive source inserted via an applicator into the vagina/cervix; delivering a higher dose to the tumour with less toxicity to surrounding organs
4 cisplatin toxicities
- peripheral neuropathy
- hearing impairment
- bone marrow suppression
- renal impairment
risk factors for cervical cancer
- multiple sexual partners
- HPV infection
- early onset of sexual activity
- immunosuppression
- 45 to 59 years
symptoms of cervical cancer (although typically late signs )
- abnormal vaginal bleeding
- postcoital bleeding
- mucoid/purulent vaginal discharge
management of cervical cancer in pregnancy
MDT
delivery at 35 weeks
CIN I
low grade lesion with mildly atypical cellular chamnge in lower 1/3 epithelium
CIN II
high grade lesion with moderately atypical cellular changes confined to basal 2/3 epithelium
CIN III
severely atypical cellular changes encompassing greater than 2/3 of epithelial thickness and includes full thickness lesions
(severe dysplasia or CIS)
