Hodgkins lymphma Flashcards
what is hodgkins lymphoma
malignant proliferation of lymphocytes characterised by the presence of reed sternberg cells
features
- painless, non tender, asymmetrical lymphadenopathy
- weight loss, pruritus, night sweats, fever
- alcohol pain
biochem findings
- normocytic anaemia
- oesinophilia
- raised LDH
staging system
ann arbor
how is ann arbor staging worked out
CT scanning of chest, abdomen and pelvis
outline Ann Arbor staging
stage 1 - cancer in a single region
stage 2 - indicates cancer is located in 2 separate regions; both affected areas are confined to one side of the diaphragm
stage 3 - indicates the cancer has spread to both sides of the diaphragm, including one organ or area near the lymph nodes of spleen
stage 4 - diffuse or disseminated involvement of one or more extra-lymphatic organs, including: bone marrow, liver, nodular involvement of lung
A/B
S
E
X
A/b - absence or presence of B symptoms
S - if disease has spread to spleen
E - used if disease is extranodal
X - used if large deposits, > 10 cm or whether the mediastinum is wider than 1/3 of the chest on x ray
name a hodgkins lymphoma clinical trial
RATHL
CTCAE
common terminology criteria for adverse effects
grades severity of side effects to held guide management
most common subtype in developed countries
nodular sclerosing
risk factors
- EBV infection
- postive fhx
- young adults from higher socio-economic class
1st line management
chemotherapy + radiotherap
histological subtype safely observed in asymptomatic relapses
nodular lymphocyte predominant
cytotoxic chemotherapy commonly used in Hodgkins, and many other cancers and is cardiotoxic in 10-30%
Doxorubicin
most common chemotherapy drug
Cisplatin
