Question of the day 2 Flashcards
What profile would you expect in a dog with hypervitaminosis D?
A) Low Ca, High P
B) High Ca, Low P
C) High Ca, High P
D) Low Ca, Low P
C) High Ca, High P
Excessive intake of vitamin D is associated with an increase in 25-hydroxyvitamin D3 levels. At high levels, 25-hydroxyvitamin D3 competes with 1,25-dihydroxyvitamin D3 for its receptors on the intestines and bone causing increased absorption of Ca and P from the intestinal tract and resorption of bone causing increased levels of circulating Ca and P. A common source of confusion is that this is in contrast to PTH which causes high Ca but generally causes unchanged or normal phosphorus because it also enhances renal phosphorus excretion.
Which one of the following sets of conditions predispose a cow to metritis?
A - Agalactia, milk fever, bovine vibriosis
B - Contaminated calving environment, abortion, hypomagnesemia
C - Milk fever, malnutrition, excess dietary zinc
D - Strep. agalactiae mastitis, retained placenta, laminitis
E - Dystocia, overfeeding in dry period, Ca-P imbalance in feed
E) Dystocia, overfeeding in dry period, Ca-P imbalance in feed
You need to perform a CBC and take thoracic radiographs on a somewhat fractious cat. You sedate the cat with an intramuscular injection of medetomidine. While on the X-ray table, you become concerned that the cat is not doing well and you decide you want to reverse the effects of medetomidine. What should you give the cat?
A) Atropine
B) Atipamezole
C) Flumazenil
D) 2-pralidoxime
E) Xylazine
B) Atipamezole
Atipamezole (trade name: Antisedan), an alpha-2 antagonist, is the reversal agent for medetomidine (trade name: Dormitor). Medetomidine is an alpha-2 agonist.
Xylazine would be another example of an alpha-2 agonist. Yohimbine is its reversal agent. Other alpha-2 agonists are clonidine, detomidine, dexmedetomidine and romifidine
2-pralidoxime is a reversal agent for cholinesterase inhibitors.
Flumazenil is a reversal agent for benzodiazepines
Atropine is a muscarinic antagonist of acetylcholine and may be dangerous to use after administration of alpha-2 agonists. This is because alpha-2 agonists cause marked vasoconstriction and high afterload on the heart. Giving atropine and increasing the heart rate can place further stress on the heart. You do not want to set in motion peripheral vasoconstriction and compensatory bradycardia brought on by the alpha-2, then increase the heart rate against that high afterload. This could make for an unhappy heart in the event underlying subclinical heart disease is present.
A six-year-old female spayed cocker spaniel is presented with a two-day history of lethargy. Upon physical exam, mucosal petechiae and ecchymoses and an ocular hemorrhage in the right eye are noted.
Prothrombin time (PT) and activated partial thromboplastin time (aPTT) testing are normal. A buccal mucosal bleeding time (BMBT) is performed and is prolonged. Click the labwork icon to review hematology, blood chemistry, and urinalysis test results.
Which one of the following diseases is the most likely diagnosis?
A - Disseminated intravascular coagulation (DIC)
B - Anticoagulant rodenticide toxicity
C - Hepatic insufficiency
D - Von Willebrand’s disease
E - Immune-mediated thrombocytopenia
E)
A 16-year old budgerigar presents with progressive unilateral paresis of the right leg (see image). There is normal flexion and extension of the hip joint with decreased flexion, extension, and sensation below the knee. The remainder of your skeletal and neurologic examination is unremarkable. Which of the following is most likely in this bird?
A) Marek’s disease
B) Renal neoplasia
C) Intervertebral disc disease
D) Botulism
E) Lead toxicosis
B) renal neoplasia
The signalment and progressive unilateral paresis are most suspicious for renal neoplasia of budgerigars. Affected birds develop paresis due to pressure exerted on the sciatic nerve by a renal tumor. There is typically normal flexion and extension of the hip joint with decreased flexion, extension, and sensation below the knee as described here.
Disc disease is uncommon in birds. Lead toxicity can lead to peripheral neuropathy and paresis but typically there are more multifocal or other accompanying signs such as polyuria/polydipsia, gastrointestinal signs, wing droop, head tilt, or convulsions. Marek’s disease typically affects younger animals. Botulism typically presents with flaccid paralysis of the legs, wings, and neck.
A budgerigar is showing signs of squamous metaplasia of the oral mucosa, conjunctiva, and upper airways. It has developed associated bacterial sinusitis (see image). In a pet bird, what are these clinical signs most suggestive of?
A) Hypovitaminosis A
B) Hypervitaminosis D
C) Hypovitaminosis D
D) Iodine deficiency
E) Hypocalcemia
Hypovitaminosis A
The correct answer is hypovitaminosis A. The functions of vitamin A are related to epithelial maintenance, vision, and skeletal development. In birds, problems with the skeleton or vision are rarely seen with vitamin A deficiency. Vitamin A deficiency can manifest as squamous metaplasia of the oral mucous membranes or glands. Glands may be entirely converted to squamous epithelium with keratin material and can look like abscesses or pustules but are essentially keratin cysts. They should be differentiated from lesions of pox, Candida, and Trichomonas. Lesions of the conjunctiva, nasolacrimal duct, upper GI tract, and upper respiratory tract can occur. Presenting signs may include severe dyspnea or respiratory signs.
Pemphigus foliaceus, pemphigus vulgaris, and bullous pemphigoid are examples of which type of immune-mediated disease?
A - Delayed hypersensitivity
B - Type III - Antigen-antibody complexes deposited in tissues
C - Type IV - Antigen triggers cell-mediated cytokine release, activates macrophages and production of cytotoxic T cells
D - Type II - Antibody binds cell antigen and activates complement
E - Type I - Immediate IGE-mediated hypersensitivity
D - Type II - Antibody binds cell antigen and
A 4-year old female spayed Siberian Husky presents for further evaluation as a result of developing crusting and hyperkeratosis around the eyes, nose, and mouth. A skin scraping did not identify an etiology. How would you treat this dog?
A) Daily wiping with chlorhexidine pads
B) Corticosteroids
C) Zinc supplementation
D) Ivermectin treatment
C) Zinc supplementation
Zinc responsive dermatopathy occurs most frequently in the Siberian Husky. Other species such as cattle, goats, and humans have a similar condition. The exact cause is unknown, but it has been linked to defective intestinal absorption of zinc. Lesions may vary in severity. The response is typically seen within days. The key to answering this question appropriately was to recognize the signalment of the patient, the location of the lesions which is characteristic of zinc responsive dermatopathy, and the fact that there was no infectious etiology such as demodex identified.
Severe combined immunodeficiency is a lethal autosomal recessive trait in Arabian foals. Heterozygotes are clinically normal. If the heterozygote carrier rate for the genetic mutation is 8%, what is the expected frequency of Arabian foals that are homozygous for the mutated allele?
0.64%
0.064%
0.16%
25%
2%
4%
0,16%
You do not need to know anything about the disease in this question in order to get the correct answer. You are told that the disease is recessive and has a carrier rate of 8%
Because the trait is recessive, homozygotes will be the only individuals affected. In order for a foal to be born homozygous for the trait, BOTH parents MUST be carriers. The chances of both parents being carriers is 8% x 8% (or 0.08 x 0.08) = 0.0064 or 0.64%. If both parents are carriers, the offspring has a 1 in 4 chance of inheriting two mutant alleles (50% chance for each allele from each parent).
Since the chances of both parents being carriers is 0.64% and the chance of having a homozygous offspring in that case is 1 in 4, the overall expected frequency of diseased foals is 0.0064 x 0.25= 0.0016 or 0.16%.
Which of these drugs should not be used in Greyhounds?
Morphine
Thiopental
Ivermectin
Propofol
Thiopental
The correct answer is thiopental. Thiopental is an ultra-short acting barbiturate. Recovery depends on redistribution to tissues, including fat. Because sighthounds have very little fat, they have prolonged recoveries and greater complications with these drugs.
A sow farm is seeing a sudden onset of diarrhea followed by collapse and death in piglets one to five days of age in the farrowing rooms. Necropsy on one of the piglets finds the lesions shown below.
What should be done next?
A - Prevent neonates from drinking sow’s colostrum
B - Treat affected piglets with antibiotics
C - Tilmicosin IM, all piglets, isolate sick ones
D - Vaccinate dams in middle third of pregnancy with bacterin
E - Treat newborn piglets at birth with type C antitoxin
E - Treat newborn piglets at birth with type C antitoxin
The image shows an infarct in the liver discovered on post mortem exam of a mature beef cow which died one hour before in a western mountain pasture, after being observed to appear normal one day earlier. There is also dark red urine in the bladder. The pasture contains native plants, some pine trees, and a marshy area with water plants. The cows are unvaccinated and were never wormed. Given this history and the lesion found, the most likely cause of death is _________.
A) Pine needle poisoning
B) Blue-green algae toxicity
C) Bacillary hemoglobinuria
D) Death camas toxicity
E) Viral hepatitis
C) Bacillary hemoglobinuria
A 12-year-old Belgian draft horse gelding is presented with severe hyperkeratosis and scaling on the caudal aspects of all four pasterns. The parasite shown below is found on a skin scraping of one of the lesions.
Which one of the following choices is the correct diagnosis?
A - Chorioptic mange
B - Cheyletiellosis
C - Demodecosis
D - Trombiculiasis
E - Sarcoptic dermatitis
A) chorioptic mange
A chicken operation has recently been ravaged by a respiratory disease affecting almost all of the chickens in the flock. The chickens are coughing and sneezing and many have facial swelling. You necropsied many of the chickens and found mucoid exudate in the bronchi, thickened air sacs, and in a few of the chickens, interstitial nephritis was present. Which of these diseases is likely?
A) Aspergillus
B) Infectious bronchitis
C) Infectious bursal disease
D) Fowl cholera
B) infectious bronchitis
The correct answer is infectious bronchitis. This is caused by a coronavirus. It is spread by aerosol and ingestion and usually affects all exposed birds. The clinical signs and necropsy findings are as described in the question. The disease can be clinically indistinguishable from mild forms of Newcastle disease, laryngotracheitis, and infectious coryza. Virus isolation is needed to obtain a definitive diagnosis.
The calf shown below was presented with ataxia, intention tremors, and hypermetria; all signs were present since birth.
The second image shows a normal bovine calf brain on the left and the brain from this calf on the right.
Which one of the following choices is the most likely cause of the disorder in this calf?
A - Copper deficiency
B - Organophosphate toxicity
C - Bovine viral diarrhea virus
D - Border disease
E - Caudal occipital malformation syndrome
C - Bovine viral diarrhea virus
A 4-year old male castrated Basenji presents for polyuria, polydipsia, and weight loss. Blood work shows P=2.5 (2.9-5.3 mg/dl), K= 3.1 (3.9-5.1 mEq/L), total CO2= 12 (17-25 mmol/L). The remainder of the blood work is within normal limits. Urinalysis shows 3+ glucose. Which of the following is your most likely differential diagnosis?
A) Fanconi syndrome
B) Pyometra
C) Diabetes mellitus
D) Pyelonephritis
The correct answer is Fanconi syndrome. Fanconi syndrome is an inherited disease in Basenjis. The disease involves renal tubular defects causing an abnormal loss of electrolytes and solutes leading to hypophosphatemia, hypokalemia, and metabolic acidosis. DM is less likely because serum glucose is normal. The lab abnormalities present in this dog are not consistent with pyelonephritis. Pyometra is not a viable choice as the signalment describes a male.
A 12 week old chicken from a young backyard flock is presented for evaluation because of weight loss, decreased appetite, and diarrhea.
The irises in the affected bird are lighter than normal with irregular pupillary margins, and the hen does not have a normal pupillary light reflex (bottom chicken in image). Several other young birds appear to be growing poorly compared to the rest of the flock.
Based on the presumptive diagnosis, how can this problem be prevented going forward?
A - Buy only vaccinated chicks
B - Cull birds from the same genetic line
C - Collect pharyngeal swabs from affected birds; Antibiotic Tx for entire flock based on culture and sensitivity
D - Isolate unaffected animals; Breed from survivors of disease
E - Use only mycoplasma-resistant bloodlines for new additions to flock
What is the most common cause of maxillary sinusitis in a horse, as seen in the necropsy image below?
Brachygnathia
Guttural pouch mycosis
Foreign body
Tooth root abscess
Dentigerous cyst
The correct answer is tooth root abscess. Commonly the first molar teeth are involved. Clinical signs include weight loss, quidding (dropping half chewed feed), halitosis, swelling, and unilateral purulent nasal discharge.
A 22-year-old Thoroughbred mare is presented for bilateral green nasal discharge, retching, coughing, and inappetence noted after feeding this evening.
The owner recently switched the mare to a pelleted diet because of the mare’s poor dentition.
Physical exam reveals bilateral green nasal discharge. The mucous membranes are pink and moist with a capillary refill time of 1.5 seconds.
A slight swelling is notable in the proximal-left jugular groove just caudal to the vertical ramus of the mandible.
Based on the most likely diagnosis, what initial therapy would be recommended?
Value Normal
100.6 F (38.1 C) 99.1–100.8 F, 37.3–38.2 C
HR=40 bpm 28-40 bpm
R=12 brpm 10-14 brpm