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Introduction to Pharmacology > Quantitative Pharmacokinetics > Flashcards

Quantitative Pharmacokinetics Flashcards

1
Q

What is experimental pharmacokinetics?

A

Biological sampling techniques, analytical methods and data collection

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2
Q

What is theoretical pharmacokinetics?

A

The development of models that facilitate prediction of drug action

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3
Q

What is D oral?

A

The dose given orally

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4
Q

What is D IV?

A

The dose give intravenously

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5
Q

What is mg/kg?

A

The milligrams given per kilogram of bodyweight

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6
Q

How can a drug concentration be measured?

A

Take a blood sample
Extract the plasma through centrifugation
Run through a specific assay

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7
Q

What is the Cmax?

A

The maximum concentration of the drug that the blood plasma reaches

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8
Q

What is the Tmax?

A

The time it takes for the maximum concentration to be reached

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9
Q

Before Tmax which phase is dominant?

A

Absorptive phase

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10
Q

After Tmax which phase is dominant?

A

Excretive phase

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11
Q

What is the MEC?

A

Minimum effective concentration

The minimum concentration of a drug needed for a therapeutic effect

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12
Q

What is the MTC?

A

Minimum toxic concentration

The minimum concentration of a drug needed to be fatal

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13
Q

What does the area under the curve measure?

A

The amount of drug present in the systemic circulation altogether

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14
Q

What does an order 0 elimination curve look like?

A

Linear

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15
Q

What does a first order elimination curve look like?

A

Decreasing exponent

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16
Q

How can we use the oral data quantitatively?

A

Compare to the intravenous data where bioavailability is 100%

17
Q

What is Fa?

A

The amount of drug that is absorbed by the gut

18
Q

What is Fg?

A

The amount of drug that passes the intestinal first pass

19
Q

What is Fh?

A

The amount of drug that passes the hepatic first pass

20
Q

What is Vd?

A

Volume of distribution

The fluid volume required to contain the amount of drug present in the body at the same concentration of the plasma

21
Q

What determines Vd?

A

Permeability of the membrane to the drug
Binding affinity to plasma proteins
pH

22
Q

What is the goal with dosing regimens?

A

To achieve a steady state within the therapeutic region

Introduction to Pharmacology (12 decks)

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