Quantitative Leukocyte disorders

Question 1

Terminologies:
philia : ________________
penia : ________________

Answer 1

• increased in quantity
• decreased in quantity

Question 2

an increase in the number of circulating young or immature granulocytes in the peripheral blood especially in the number of bands

Answer 2

Left shift

Question 3

An exaggerated response to infections and inflammation in which the baseline leukocyte count may be between 20 and 50x10^9/L

Answer 3

Leukomoid reaction

Question 4

above 50x10^9/L with neutrophilia and a marked left shift

Answer 4

Leukocytosis (Reactive)

Question 5

Determines whether it is a Leukemoid reaction or Chronic myelogenous anemia

Answer 5

Lap score

Question 6

*Immature white cells, immature red cells, and platelet abnormalities
*A significant feature of the myeloproliferative disorders

Answer 6

Leukoerythroblastic picture

Question 7

Compare and contrast Chronic myelogenous anemia from leukomoid reaction

Answer 7

Both have mature cells, however, they only differ whether it is leukemic or not.

*Chronic Myelogenous Anemia - it is a leukemia
*Leukomoid Reaction - is not a leukemia,

Question 8

No absolute decrease in neutrophils

Answer 8

Pseudoneutrophilia

Question 9

Causes of pseudoneutrophilia

Answer 9

Severe exercise, hypoxia, stress, or injection of epinephrine

Question 10

Release and detachment of leukocytes from receptors on vessel luminal walls

Answer 10

Demargination

Question 11

inability to release mature granulocytes into the blood

Answer 11

Myelokathexis

Question 11

depress the production of white blood cells in the bone marrow; suppress the immune system

Answer 11

Leukopenia

Question 12

Syndrome of paroxysmal cough and bronchospasm associated with marked eosinophilia

Answer 12

Tropical Pulmonary Eosinophilia

Question 13

*Also called “simple eosinophilic pneumonia”
*Sputum that contains eosinophils w/ the presence of Charcoat Leyden crystals

Answer 13

Loffler Syndrome

Question 14

Causes for Eosinopenia

Answer 14

*Glucocorticosteroid hormones
*Acute bacterial or viral inflammation

Question 14

in response to increased ACTH, which of the following granulocyte would decrease?

Answer 14

Basophils (Basopenia)

Question 14

suppresses the immune system like HIV for example, would imply which WBC condition?

Answer 14

Lymphocytopenia

Question 14

increase of your antibody usually cause by viral infections or bacterial, would imply which WBC condition?

Answer 14

Plasmacytosis

Question 15

*Dark blue to purple cytoplasmic granules in the metamyelocyte, band, or neutrophil stage
*Peroxidase positive

Answer 15

Toxic granulation

Question 16

toxic granulation is seen in?

Answer 16

burns, malignant disorders or drug therapy, inflammation, infection and patients receiving G-CSF therapy

Question 17

*found in band and segmented neutrophils
*bacterial infections, sepsis, and pregnancy
*Small, oval inclusions
*Pale blue with Wright’s stain

Answer 17

Dohle bodies

Question 18

Associated with increase phagocytosis

Answer 18

Cytoplasmic vacuolization

Question 19

Prolonged exposure of blood to EDTA would imply?

Answer 19

induced auto-phagocytosis

Question 20

*Inactivated X-chromosome seen in female somatic cells
*Small, well-defined, round projection (drumstick) of nuclear chromatin
*Connected to the nucleus of the neutrophil by a single fine strand of chromatin
*Found only in females

Answer 20

Barr body

Question 21

Indicator of imminent cell death;

Answer 21

Pyknotic nuclei

Question 22

Already dead cells

Answer 22

Necrotic nuclei