Quantitative Leukocyte disorders Flashcards
Terminologies:
philia : ________________
penia : ________________
- increased in quantity
- decreased in quantity
an increase in the number of circulating young or immature granulocytes in the peripheral blood especially in the number of bands
Left shift
An exaggerated response to infections and inflammation in which the baseline leukocyte count may be between 20 and 50x10^9/L
Leukomoid reaction
above 50x10^9/L with neutrophilia and a marked left shift
Leukocytosis (Reactive)
Determines whether it is a Leukemoid reaction or Chronic myelogenous anemia
Lap score
*Immature white cells, immature red cells, and platelet abnormalities
*A significant feature of the myeloproliferative disorders
Leukoerythroblastic picture
Compare and contrast Chronic myelogenous anemia from leukomoid reaction
Both have mature cells, however, they only differ whether it is leukemic or not.
*Chronic Myelogenous Anemia - it is a leukemia
*Leukomoid Reaction - is not a leukemia,
No absolute decrease in neutrophils
Pseudoneutrophilia
Causes of pseudoneutrophilia
Severe exercise, hypoxia, stress, or injection of epinephrine
Release and detachment of leukocytes from receptors on vessel luminal walls
Demargination
inability to release mature granulocytes into the blood
Myelokathexis
depress the production of white blood cells in the bone marrow; suppress the immune system
Leukopenia
Syndrome of paroxysmal cough and bronchospasm associated with marked eosinophilia
Tropical Pulmonary Eosinophilia
*Also called “simple eosinophilic pneumonia”
*Sputum that contains eosinophils w/ the presence of Charcoat Leyden crystals
Loffler Syndrome
Causes for Eosinopenia
*Glucocorticosteroid hormones
*Acute bacterial or viral inflammation
in response to increased ACTH, which of the following granulocyte would decrease?
Basophils (Basopenia)
suppresses the immune system like HIV for example, would imply which WBC condition?
Lymphocytopenia
increase of your antibody usually cause by viral infections or bacterial, would imply which WBC condition?
Plasmacytosis
*Dark blue to purple cytoplasmic granules in the metamyelocyte, band, or neutrophil stage
*Peroxidase positive
Toxic granulation
toxic granulation is seen in?
burns, malignant disorders or drug therapy, inflammation, infection and patients receiving G-CSF therapy
*found in band and segmented neutrophils
*bacterial infections, sepsis, and pregnancy
*Small, oval inclusions
*Pale blue with Wright’s stain
Dohle bodies
Associated with increase phagocytosis
Cytoplasmic vacuolization
Prolonged exposure of blood to EDTA would imply?
induced auto-phagocytosis
*Inactivated X-chromosome seen in female somatic cells
*Small, well-defined, round projection (drumstick) of nuclear chromatin
*Connected to the nucleus of the neutrophil by a single fine strand of chromatin
*Found only in females
Barr body
Indicator of imminent cell death;
Pyknotic nuclei
Already dead cells
Necrotic nuclei
