Quan Flashcards
Opsonization
tag microbial organisms for phagocytosis
Complement fixation
recruit complement system to destroy microbial organisms or infected cells
Direct neutralization
bind toxins in blood and tissue to facilitate toxin removal
IgG
Basic
Neonatal immunity
IgD
Associated with
B cells: also called B-cell receptor
IgE Associated with (4)
Surface of basophils and mast cells
Killing large parasites
Allergic reactions
IgA
Associated with
Structure
Saliva
Dimer
IgM
Characteristics
structuer
Can serve as B cell receptor
First secreted antibody
Pentamer
Central complement component
C3
Late complement component
C5, C9
Activation of complements occurs when….
Occurs when masking is removed, exposing active site
What is the active complement
Fragmetnts of complement molecules
Complements involved in opsonization
C3b
iC3b
C4b
Complements involved in chemotaxis
C3a
C5a
Complements involved in cytolysis
C5b
Classical pathway activators
antibody antigen complexes containing IgM or IgG1-3
Lectin pathway activators
Terminal mannose groups
Alternative pathway activators
Microbial cell walls
Adapter for classical pathway
C1
Activated C1 cleaves C2 and C4 to form
C3 convertase (C4b2a)
opsonins change surface from ____ to ______
Hydrophilic to hydrophobic
FCy RI
FCy RII
FCy RIII
CD64
CD32
CD16
Sole Class capable of binding human IgG2 complexes
Fcy RII
CR3
Structure
Name
Non covalently linked dimer
Integrin
CD11/CD18: MAC1
CR1
CD35
weak binding
GLycoprotein w/ single membrane spanning domain and short cytoplasmic c terminal domain
Kinds of phagocytic cells
Neutrophils Macrophages Eosinophils Basophiles Dendritic cells
