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Micro 3 > Quan > Flashcards

Quan Flashcards

1
Q

Opsonization

A

tag microbial organisms for phagocytosis

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2
Q

Complement fixation

A

recruit complement system to destroy microbial organisms or infected cells

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3
Q

Direct neutralization

A

bind toxins in blood and tissue to facilitate toxin removal

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4
Q

IgG

A

Basic

Neonatal immunity

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5
Q

IgD

Associated with

A

B cells: also called B-cell receptor

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6
Q 
IgE
Associated with (4)
A

Surface of basophils and mast cells
Killing large parasites
Allergic reactions

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7
Q

IgA
Associated with
Structure

A

Saliva

Dimer

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8
Q

IgM
Characteristics
structuer

A

Can serve as B cell receptor
First secreted antibody
Pentamer

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9
Q

Central complement component

A

C3

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10
Q

Late complement component

A

C5, C9

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11
Q

Activation of complements occurs when….

A

Occurs when masking is removed, exposing active site

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12
Q

What is the active complement

A

Fragmetnts of complement molecules

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13
Q

Complements involved in opsonization

A

C3b
iC3b
C4b

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14
Q

Complements involved in chemotaxis

A

C3a

C5a

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15
Q

Complements involved in cytolysis

A

C5b

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16
Q

Classical pathway activators

A

antibody antigen complexes containing IgM or IgG1-3

17
Q

Lectin pathway activators

A

Terminal mannose groups

18
Q

Alternative pathway activators

A

Microbial cell walls

19
Q

Adapter for classical pathway

A

C1

20
Q

Activated C1 cleaves C2 and C4 to form

A

C3 convertase (C4b2a)

21
Q

opsonins change surface from ____ to ______

A

Hydrophilic to hydrophobic

22
Q

FCy RI
FCy RII
FCy RIII

A

CD64
CD32
CD16

23
Q

Sole Class capable of binding human IgG2 complexes

A

Fcy RII

24
Q

CR3
Structure
Name

A

Non covalently linked dimer
Integrin
CD11/CD18: MAC1

25
Q

CR1

A

CD35
weak binding
GLycoprotein w/ single membrane spanning domain and short cytoplasmic c terminal domain

26
Q

Kinds of phagocytic cells

A 
Neutrophils
Macrophages
Eosinophils
Basophiles 
Dendritic cells

Micro 3 (7 decks)

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