L34 Bailey antigen procession

Question 1

Pattern recognition receptors

Answer 1

Mannose receptors
Scavenger Receptors
Toll-like receptors

Question 2

What happens when we mix e coli with macrophage

Answer 2

1. binding
2. engulf
3. phagosome formation
4. phagosome fuse with lysosome–>phagolysosome
5. membrane disruption
6. cytokines and chemokines, inflam mediators

Question 3

Requirements for T cell response

Answer 3

Cell surface peptides of antigen presented by cells expressing MHC antigens

Question 4

MHCI vs MHCII

Answer 4

MHCI: cytoplasmic protieins
MHCII: extracellular proteins bound

Question 5

Cytokines that attract cells

Answer 5

Chemokines

Question 6

Cytokine action

Answer 6

brief, self limited

Question 7

Cytokine action

Answer 7

pleitropic and reduntant

Synergy or antagonistic

Question 8

Cytokine signalling

Answer 8

Mostly paracrine
IL-2 does autocrine
Chemockines and TNF-alpha are endocrine

Question 9

Cytokines initiate action by

Answer 9

binding to specific membrane bound receptors