QC

Question 1

Use according to particular state of needs to guarantee the products quality asset by its monograph and is specification

Answer 1

Special methods of analysis

Question 2

Are made to establish purity for determine the amount of therapeutically active constituents present for the purpose of standard decision

Answer 2

Quantitative analysis of crude drugs and products

Question 3

classification for the special methods

Answer 3

Chemical methods and biological methods

Question 4

Ash determination, crude extractive fiber content, assay of alkaloids and volatile oils

Answer 4

Chemical methods

Question 5

In vivo animal testing, microbiological testing and etc.

Answer 5

Biological methods

Question 6

Usually taken as a measure of the residue from a crude drug after the process of incineration

Answer 6

Ash content

Question 7

It represents the amount of inorganic salts naturally occurring in the drug and adhering to it

Answer 7

Ash content

Question 8

It can also represent the level of inorganic matter that indicates a level of adulteration of a crude drugs sample

Answer 8

Ash content

Question 9

Process of subjecting the crude drug sample to very high temperatures in order to “burn off” organic matter living in organic matter for total Ash measurement

Answer 9

Incineration

Question 10

This is the residue remaining after application of sufficient incineration process

Answer 10

Total ash

Question 11

This is part of the total Ash that cannot be solubilized in dilute hydrochloric acid

Answer 11

Acid insoluble ash

Question 12

This is the processed done to crucibles to dull redness and afterwards weight is measured. The Crucible is deemed as constant weight when to 2-3 weighings do not differ by 0.5mg

Answer 12

Constant weight

Question 13

This is a crucibles that has been heated to dull redness and until constant weight, cooled in a dessicator and weighed

Answer 13

Tared crucible

Question 14

Define as a quantity not exceeding 500mcg

Answer 14

Negligible

Question 15

Is a measure of inorganic matter present a impurity

Answer 15

Ash o residue yielded by an organic compound

Question 16

Used to conduct incineration studies and temperatures for incineration

Answer 16

Electric furnace

Question 17

Very dull red heat

Answer 17

500-550°C

Question 18

550-700°C

Answer 18

Dull red heat

Question 19

Bright red heat

Answer 19

800-1000°C

Question 20

1000-1200°C

Answer 20

Yellow red heat

Question 21

White heat

Answer 21

1200-1600°C

Question 22

Is determine by ignition to dull redness

Answer 22

The Ash content of chemicals

Question 23

This technique provides a means of determining the percentage of test material which is volatilized and driven off under the conditions specified

Answer 23

Loss of ignition

Question 24

USP calamine

Answer 24

2%

Question 25

Magnesium sulfate

Answer 25

40-52%

Question 26

Titanium dioxide

Answer 26

0.5%

Question 27

Zinc oxide

Answer 27

1%

Question 28

NF Calcium phosphate

Answer 28

8%

Question 29

Kaolin

Answer 29

15%

Question 30

Lime

Answer 30

10%

Question 31

Magnesium hydroxide

Answer 31

30-33%

Question 32

Magnesium phosphate

Answer 32

20-27%

Question 33

Also known as moisture content analysis

Answer 33

Water content

Question 34

Is a critical component of material quality and essentially a function of quality control in most production and laboratory facilities, from biological research organization, pharmaceutical manufacturers to food producers and packers

Answer 34

Water content

Question 35

Greatly influences the physical properties and product quality of nearly all substances and materials at all stages of processing and final product existence

Answer 35

Moisture content control

Question 36

In the water content determination, these influences chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and polymer film permeability in solid dosage forms and lead to growth of microorganisms, change in thixotropy in semi-solid dosage forms.

Answer 36

Presence of moisture

Question 37

It influences the properties of individual active ingredients and excipients, and it is essential to characterize the effect of moisture on this individual components

Answer 37

Moisture

Question 38

Six methods for determining water content

Answer 38

Gravimetric for drugs containing no constituents other than water, volatile at 105 °C Gravimetric for drugs containing ether- soluble constituents volatile at 105°C Azeotropic Toluene distillation Karl fischer titration Dew point Electrolytic hygrometric

Question 39

For drugs which contained no constituents volatile at ____ other than ____ , about ___ of the drug is accurately weighed and dried in an oven at _____ for ___ hours. After ___ hours , the sample is Weighed and again dried at ___ hour intervals until the loss in weight is not more than____ in 1 hour of drying

Answer 39

105°C, water, 10g, 105°C, 5 hours, 5 hours, 1 hour, 0.25%

Question 40

This represents the moisture present in the sample

Answer 40

The weight loss of the drugs

Question 41

Vegetables drugs volatile substances

Answer 41

Essential oils, ethers, esters, amines

Question 42

A.K.A drying or thermal method

Answer 42

Gravimetric method

Question 43

Gravimetric method of choice are

Answer 43

1-2g chemical sample Vegetable drugs (10g) dried for 5 hours Biologics

Question 44

It is a better method that has been developed and was modified and is now one of the official methods for moisture determination

Answer 44

Xylene method

Question 45

Xylene method also known as

Answer 45

Azeotropic method

Question 46

Solvents used in azeotropic distillation

Answer 46

Xylene and toluene

Question 47

The primary standard use in karl fischer is

Answer 47

Sodium tartrate

Question 48

The contents of the karl Fischer reagents are

Answer 48

Anhydrous methanol Iodine Sulfur dioxide Pyridine

Question 49

This prevents pyridine-sulfur complex

Answer 49

Anhydrous methanol

Question 50

This react with water to form hydroiodic acid

Answer 50

Iodine

Question 51

Reacts with water the form sulfur Trioxide

Answer 51

Sulfur dioxide

Question 52

This prevents the reversal of the reaction

Answer 52

Pyridine

Question 53

This method doesn't use chemicals or high temperatures

Answer 53

Dew point

Question 54

This use instruments and infrared beam focused in a tiny mirror

Answer 54

Dew point

Question 55

Is an improved method in measuring the moisture content of gases less than 1 ppm

Answer 55

Electrolytic hygrometric

Question 56

The amount of insoluble in a given solvent

Answer 56

Index of purity

Question 57

Generally use for extraction with volatile solvents or small quantities of the are to be extracted

Answer 57

Soxhlet Apparatus

Question 58

The top of the extraction thimble should be ___ level of the Siphon tube

Answer 58

Above

Question 59

These are applied for the approximate determination of volatile oils contained

Answer 59

Volatile ether-soluble extractives

Question 60

These are applied for the approximately termination of active constituents associated with volatile matter contain

Answer 60

Non-volatile ethers-soluble extractives

Question 61

Most commonly employed method in the analysis of resinous substances present

Answer 61

Alcohol - soluble extractives

Question 62

Alcohol dissolves

Answer 62

Resins, benzoic acid, benzaldehyde, cinnamic acids , styrenes, vanillin and esters

Question 63

this is frequently added to the receiving flask to produce non-volatile salts from the volatile acids

Answer 63

NaOH

Question 64

Best solvents for fats and fatty oils

Answer 64

Hexane

Question 65

This method provides and index of the amount of fat sample and amount of seeds in some plant materials

Answer 65

Hexane - Soluble extractives

Question 66

Is the residue that remains undissolved after successive treatment with boiling alkali and acid

Answer 66

The crude fiber content

Question 67

Crude fiber is produced from

Answer 67

Deterioration

Question 68

is usually the outer cellular layer or protective coating, hence , a high crude fiber content as compared to product monograph usually indicates adulteration

Answer 68

Crude fiber

Question 69

This is defined as the number of mg KOH necessary to neutralize the free acids in 1g of oil, fat, wax , resins, balsam, or similar organic substances of complex composition

Answer 69

Acid value

Question 70

Also known as acid number or acidity index

Answer 70

Acid value

Question 71

For the titration of acid value, ___ concentration is the most suitable

Answer 71

0.1N

Question 72

It is defined as the number of mg of KOH required to neutralize the free acids and saponify the esters contained in 1g of fat, fatty or volatile oils , wax, resins, balsam, or other substances of similar composition

Answer 72

Saponification Value

Question 73

Also known as Koettsdorfer number

Answer 73

Saponification Value

Question 74

This is defined in the U.S.P as the substances present in oils or fats that are not saponified by alkali hydroxides but are soluble in ordinary fat solvents

Answer 74

Unsaponifiable matter

Question 75

This the number of mg of KOH required to saponify the esters in 1g of a fatty or volatile oil, fat, wax , balsam, resins , or similar substances

Answer 75

Ester Value

Question 76

Also known as ester number

Answer 76

Ester Value

Question 77

The number of grams of iodine absorbed under specified condition by 100g of oil, fat, wax, or other substances

Answer 77

Iodine value

Question 78

Quantitative measure of the proportion of unsaturated fatty acids present, both free and combined as esters, that have the property of absorbing iodine

Answer 78

Iodine value

Question 79

Is the number of milligrams of potassium hydroxide equivalent to the hydroxyl content of 1g of the substance

Answer 79

Hydroxyl value

Question 80

This constant gives an indication of identity and purity of fatty substances possessing alcoholic hydroxyl groups

Answer 80

Hydroxyl value

Question 81

Inversely proportional to the molecular weight

Answer 81

Hydroxyl value

Question 82

Corresponds closely to the hydroxyl value of fatty alcohols , and the two constants yave much the same significance with respect to identity and purity of the substances

Answer 82

Acetyl value