Pyruvate Dehydrogenase & Citric Acid Cycle Flashcards
1
Q
how is pyruvate transported from the cytosol to the mitochondrial matrix?
A
by a pyruvate carrier molecule across the inner mitochondrial membrane
2
Q
what is the overall reaction catalyzed by the PDH complex?
A
pyruvate, free CoA (SH-CoA) and NAD+ are used to form CO2, acetyl CoA, NADH
3
Q
what activates PDH?
A
dephosphorylation
insulin
catecholamines
Ca2+ in skeletal muscle
4
Q
what inhibits PDH?
A
phosphorylation
acetyl Co A
ATP
NADH
5
Q
what happens when you have a pyruvate dehydrogenase deficiency?
A
increase pyruvate, increase LA, decrease ATP production
lactic acidosis etc.
6
Q
what illneeses result of thiamine deficiency?
A
werneke Korsakoff
beri beri
7
Q
what happens during arsenic poisoning?
A
it binds to lipoylic acid in PDH!
