Pyrexia of Unknown Origin Flashcards
1
Q
What is the definition of pyrexia of unknown origin?
A
Temperature >38 on multiple occasions
Illness of >3 weeks
No diagnosis despite >1 week inpatient
2
Q
What are common causes?
A
Infection
- TB
- abscesses
- infective endocarditis
Autoimmune
- Still’s disease
- temporal arteritis
Neoplastic
- leukaemias
- lymphomas
Other
- drugs
- thromboembolism
- hyperthyroidism
- adrenal insufficiency
3
Q
What are important questions in history?
A
Timing of symptoms Recent travel Medications Occupation Animal exposure Sexual history
4
Q
How is it investigated?
A
Bloods
- FBC
- U+Es
- CRP
- LFTs
Blood cultures
Urinalysis
CXR
5
Q
How is PUO managed?
A
Aim to establish diagnosis
