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Infectious Diseases > Pyrexia/Fever Of Unknown Origin > Flashcards

Pyrexia/Fever Of Unknown Origin Flashcards

1
Q

What are the three characteristics of PUO?

A

Fever>38.3 Celsius on at least 3 occasions
Persisting without diagnosis > 3 weeks
In spite of investigation on at least 3 days (outpatient or admitted)

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2
Q

What are the 4 classifications of PUO?

A

Classical
Nosocomial
HIV-associated
Neutropaenic

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3
Q

What are the three causes of Classic PUO?

A

Infection
Malignancy
Collagen vascular disease

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4
Q

What is the difference between patients with classic PUO and Nosocomial PUO?

A

Nosocomial PUO - fever in patients who have been hospitalised > 24hrs but no fever on admission

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5
Q

How to differentiate patients with neutropenic PUO?

A

They have neutrophil count <= 500per mm3

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6
Q

What is the difference for HIV associated PUO patients?

A

Duration of fever must be >4 weeks for outpatients and >3 days for inpatients

HIV infection must be confirmed

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7
Q

What is the percentage of infectious causes of classic PUO?

A

17-35%

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8
Q

What is the % of non infectious inflammatory causes of classic PUO?

A

26-36%

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9
Q

What is the % of Neoplastic causes of classic PUO?

A

10-20%

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10
Q

What is the % of Miscellaneous causes of classic PUO?

A

3-15%

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11
Q

What is the % of undiagnosed classic PUO?

A

16-39%

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12
Q

What are some of the BACTERIAL causes of infectious classic PUO?

A

TB, infective endocarditis (culture neg) osteomyelitis, occult abscess

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13
Q

What are some of the VIRAL causes of infectious classic PUO?

A

Ebstein-Barr virus
HIV
Cytomegalovirus

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14
Q

What is the common cause for PARASITIC infectious classic PUO?

A

Malaria

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15
Q

What is the common cause for FUNGAL Infectious classic PUO?

A

Histoplasmosis

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16
Q

What are non infectious causes of classic PUO?

A

Giant cell arthritis
Systemic lupus erythematosis
Rheumatoid arthritis
Adult onset stills disease

17
Q

What are the malignant causes of classic PUO ?

A

Lymphoma*
Leukaemia
Renal cell carcinoma
Hepatocellular carcinoma
Colon carcinoma

18
Q

What are some of the miscellaneous causes of classic PUO?

A

Drugs
Hereditary
Deep vein thrombosis
Inflammatory bowel disease
Kawasakis syndrome

19
Q

Where are occult abscesses for classic PUO usually located?

A

Abdomen or pelvis
-they develop secondary to appendicitis or diverticulitis

Infectious Diseases (9 decks)

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