Pyoderma Gangrenosum Flashcards
Pyoderma gangrenosum is a rare skin condition. Which of the following is the cause?
1 - neutrophil dysfunction
2 - bacterial infection
3 - viral infection
4 - allergic reaction
1 - neutrophil dysfunction
- dense infiltration of neutrophils in the affected tissue and this is often seen on biopsy
Pyoderma gangrenosum is a rare, non-infectious, inflammatory disorder. It is an uncommon cause of very painful skin ulceration. Which part of the body does this typically affect?
1 - head
2 - arms
3 - torso
4 - legs
4 - legs
How common is pyoderma gangrenosum?
1 - 500 : 100,000
2 - 50 : 100,000
3 - 5 : 100,000
4 - 0.5 : 100,000
4 - 0.5 : 100,000
What is the average age of onset of pyoderma gangrenosum?
1 - 15-25
2 - 30-40
3 - 40-60
4 - >75
3 - 40-60
Are men or women more commonly affected by pyoderma gangrenosum?
- women
All of the following have been identified as a potential cause of pyoderma gangrenosum, but which of the following accounts for aprox 50% of cases?
1 - IBD
2 - idiopathic
3 - Crohn’s
4 - RA and SLE
5 - myeloproliferative disorders
(lymphoma, myeloid leukaemias
monoclonal gammopathy (IgA)
6 - granulomatosis with polyangiitis
7 - primary biliary cirrhosis
2 - idiopathic
Pyoderma gangrenosum can present in a number of ways. Which of the following is NOT typically used when describing how it can present acutely?
1 - small pustule
2 - red bumps
3 - blood-blister
4 - ulceration
4 - ulceration
- typically occurs later
- patients are typically in a lot of pain, may be out of proportion to clinical findings
In addition to the skin features of Pyoderma gangrenosum, which of the following can patients also present with?
1 - fever
2 - malaise
3 - myalgia
4 - arthralgia
5 - all of the above
5 - all of the above
Diagnosis is often a diagnosis of exclusion following negative findings, but what is the 1st line therapy when treating pyoderma gangrenosum?
1 - oral antibiotics
2 - oral antivirals
3 - oral steroids
4 - topical steroids
3 - oral steroids
