pyelonephritis (W3) Flashcards

1
Q

nephro

A

kidneys

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2
Q

renal

A

of or belonging to kidneys

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3
Q

nephrology

A

the study of kidneys

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4
Q

urology

A

study of urinary tract

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5
Q

lithos

A

stone

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6
Q

calculi

A

something accidental that doesn’t belong in body, like a stone

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7
Q

UTI protective factors

A

pH, acidic
presence of urea
males have prostatic secretions
females have urethral gland secretions
flow of urine is uni-directional via one way valve
immune system

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8
Q

UTI RF

A

catheters- CAUTI
women- urethra is small and short, closer to anus, and perineal irritation
age- older
pregnancy
sexual activity- especially women (spermicide/condoms)
urinary obstruction/refllux
immobility
incontinence- urine/stool
decreased cognition
bad personal hygiene

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9
Q

pathogenesis of UTI

A

ascending pattern- up

contaminated perineum to urethra to bladder (cystitis) to ureter to kidney (pyelonephritis)

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10
Q

pyelonephritis

A

upper UTI, inflammation of kidneys
ascending infection with e coli/bloodstream infection

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11
Q

major RF for pyelonephritis

A

pregnancy (fetus blocks the ureters- urine stasis)

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12
Q

pathogenesis of pyelonephritis

A

inflammation response- kidney tissue damage

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13
Q

upper UTI clinical manifestations

A

sudden onset of fever, chills, CVA tenderness
s/s of lower UTI like dysuria
accompanying s/s of N/V, anorexia

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14
Q

urosepsis

A

severe systemic response to UTI

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15
Q

urosepsis

A

severe systemic response to UTI
prognosis: high mortality
*key is early identification and treatment

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16
Q

who is at risk for urosepsis?

A

elderly
diabetics
immunocompromised

17
Q

treatment for UTI

A

antibiotics for community-acquired infections: single dose/short course (3 days)/conventional (7 days)

treatment varies depending on upper/lower UTI, complications, pregnancy, culture and sensitivity results

18
Q

first-line UTI AB

A

ciprafloxacin
moa: inhibits bacterial reproduction, works locally
can cause GI upset, BB tendon rupture

vancomyocin
for a more complex UTI