Puthoff Lecture 4 - Eye Flashcards

1
Q

What is the most common cause of irreversible visual loss in the United States?

A

Age-related macular degeneration (AMD)

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2
Q

What are Pleomorphic adenomas of the lacrimal gland?

A

Encapsulated tumor of the orbit

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3
Q

What tumor may present clinically like idiopathic orbital inflammation?

A

Metastatic prostatic carcinoma

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4
Q

What is the most common malignancy of the eyelid?

What must you do?

Metastasizes yes or no?

A

Basal cell carcinoma

Excise it

Almost never

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5
Q

A diffusely thickened eyelid suggests what pathology?

A

Sebaceous carcinoma

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6
Q

What is the most common cause of blindness world-wide?

What else can it cause?

A

Chlamydia trachomatis

Conjunctival scarring

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7
Q

What are the risk factors for pinguecula and Pterygium?

How do they grow on the eye?

Which one crosses the cornea?

A

Sun/UV exposure (surfer’s eye), male in 20s-40s

Nasal eye to lateral

Pterygium

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8
Q

What classically causes blue sclera?

A

Osteogenesis imperfecta

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9
Q

Necrotizing scleritis occurs in what disease?

A

R.A.

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10
Q

What makes up the major refractive surface of the eye?

A

Cornea and overlying tear film

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11
Q

What is well-known to cause ulcerative keratitis?

A

Herpes

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12
Q

What is calcific band keratopathy characterized by?

A

Deposition of calcium in the Bowman layer

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13
Q

What does Actinic band keratopathy develop from?

A

Chronic exposure to high levels of UV light

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14
Q

Progressive thinning and ectatic of the cornea without evidence of inflammation or vascularization is called what?

A

Keratoconus

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15
Q

Keratoconus is associated with what?

A

Down syndrome, Marfan syndrome, atopic disorders

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16
Q

What develops from loss of endothelial cells and the resulting edema and thickening of the stroma?

A

Fuchs Endothelial Dystrophy

17
Q

What are the clinical manifestations of Fuchs endothelial dystrophy?

Indication for what?

A

Stromal edema and bullous keratopathy

Corneal transplant

18
Q

What are deposits which generate discrete opacities in the cornea that may eventually compromise vision?

Mutation of what?

A

Stromal dystrophies

TGFB1

19
Q

What are the RFs for cataracts?

A
Old age
Smoking
Sun 
DM
Wilson's
Galactosemia
Atopic dermatitis
20
Q

Prolonged use of steroids (corticosteroids) as in asthma puts you at risk for what?

A

Secondary Glaucoma

21
Q

What is this describing? Peripheral zone of the iris adheres to the trabecular meshwork and physically impedes the egress of aqueous humor from the eye

A

Angle-closure glaucoma

22
Q

What is this describing? Aqueous humor has complete access to meshwork, but here is increased resistance to aqueous outflow

A

Open-angle glaucoma

23
Q

What is described by inflammation of the interior of the eye that extends into the uvea and sclera?

A

Panophthalmitis

24
Q

What describes inflammation of the interior of the eye involving the vitreous humor

A

Endophthalmitis

25
Who makes up the uvea? What is highly vascularized?
Iris, choroid, ciliary body Choroid
26
What is the most common intraocular malignancy of adults?
Metastasis to the uvea (choroid)
27
What is the most common primary intraocular malignancy of adults? How does it disseminate and where 1st?
Uveal melanoma Hematogenously to the liver
28
Wet AMD is due to what? Risk factors?
Neovascularization Smoking and intense light exposure
29
retinitis pigmentosa affects what? Causes what?
Rods/cones or RPE Visual impairment -> blindness
30
What major infectious agents cause retinitis?
Candida | CMV in AIDS Pts
31
What is the most common primary intraocular malignancy of children?
Retinoblastoma
32
Retinal lymphoma is an aggressive tumor that involves what? What kind? Spreads where and how?
Neurosensory retina and RPE Large B cell lymphomas To the brain via optic nerve
33
What is retinal hemangioblastomas associated with?
VHL syndrome
34
Swelling of the optic nerve head in elevated intracranial pressure is bilateral and termed what?
Papilledema NO LP Usually no visual loss
35
What are causes of optic neuropathies?
Leber Nutritional deficiency Methanol
36
What is a major cause of optic neuritis?
M.S.