Pulmonology Flashcards
The factor that mostly effects the prognosis of a COPD patient is:
A) The continuation of smoking
B) The reversibility of obstruction when using steroids
C) The degree of hypoxia
D) The value of FEV1
E) The presence of hypercapnia
D) The value of FEV1
In case of suspected chronic obstructive pulmonary disease, the most important examination that can confirm the diagnosis is:
A) The determination of the daily amount of sputum
B) Physical examination
C) Chest radiograph
D) Pulmonary function testing
E) Blood gas analysis
D) Pulmonary function testing
From the following symptoms which one is the most typical for bronchiectasis?
A) Cough
B) Large amount of (>50-100 ml/day), often purulent expectoration
C) Hemoptysis
D) Chest pain
E) Dyspnea
B) Large amount of (>50-100 ml/day), often purulent expectoration
From the following medication groups which one can significantly inhibit the production of mucus?
A) Theophylline
B) β2-adrenergic receptor agonists
C) Non-selective β2-blockers
D) Anticholinergics
E) Furosemide
C) Non-selective β2-blockers
Medications for the rapid treatment of asthma attacks:
A) Sedatives
B) Bronchodilators
C) Antihistamines
D) Corticosteroids
E) Chromoglycate
B) Bronchodilators
Which of the following answers is not correct?
A) Regular administration of a short-acting β2-receptor agonist bronchodilator is preferred to administration as needed.
B) Inhaled β2-agonists reach their maximal bronchodilator effect within minutes (in 5-15 minutes).
C) The efficiency of inhalation bronchodilator aerosols can be enhanced, if the patient inhales them through an inhalation piece (nebuhaler).
D) The duration of effect of long-acting inhaled β2-receptor agonist products is between 10-12 hours.
E) The most effective medications in case of bronchoconstriction are β-receptor stimulant bronchodilators.
A) Regular administration of a short-acting β2-receptor agonist bronchodilator is preferred to administration as needed.
In case of a 56-year-old, alcoholic, heavy smoker male patient with recurrent fever and cough, followed by large amount of purulent expectoration, weight loss, chest pain and poor general condition has occured. His chest x-ray shows a right upper lobe shadow with fissure formation. The most likely pathogen that caused the pneumonia with above-described clinical picture is:
A) Streptococcus pneumoniae
B) Mycoplasma pneumoniae
C) Staphylococcus aureus
D) Klebsiella pneumoniae
E) Mycobacterium tuberculosis
D) Klebsiella pneumoniae
The size of the hyperergic tuberculin reaction among the vaccinated population is (the largest diameter perpendicular to the longitudinal axis of the induration):
A) > 10 mm
B) > 15 mm
C) > 20 mm
D) > 25 mm
E) > 30 mm
B) > 15 mm
In case of newly discovered lesion, which is the size of an infant’s palm, inhomogeneous, right apical, clinically considered as TB, but is negative to Mycobacterium with direct sputum test and with PCR, which one is the recommended sufficient drug combination?
A) INH + RAMP + PZA
B) INH + RAMP
C) INH + PZA
D) INH + PZA + RAMP + EMB
E) INH + EMB
A) INH + RAMP + PZA
Which antibiotic from the followings is most likely to cause hepatitis?
A) INH
B) PZA
C) RAMP
D) PAS
E) EMB
B) PZA
Principles used in the treatment of multidrug-resistant TB patients, except:
A) At least three drugs to which the isolated bacteria are sensitive should be used.
B) First-line antituberculotic treatment should be used primarily.
C) The medication is supplemented with secondary antituberculotics to achieve a combination of four drugs.
D) At least 3-3 microscopic examinations and culture tests should be performed every three months during treatment.
E) A resistance test is need to be performed from the cultures.
F) After bacterial testing came back negative, the treatment must be continued for at least one more year.
G) Surgical solution must be considered.
D) At least 3-3 microscopic examinations and culture tests should be performed every three months during treatment.
Which treatment is contraindicated in the treatment of pulmonary embolism during pregnancy?
A) O2 addition
B) bedrest
C) early mobilization
D) administration of Syncumar
E) administration of heparin
D) administration of Syncumar
Characteristics of primer pulmonary hypertension, except:
A) progressive disease of young women
B) exertional, then resting dyspnea
C) high pulmonary wegde pressure
D) Raynaud’s phenomenon
E) effort syncope
F) right ventricular failure
G) chest pain
C) high pulmonary wegde pressure
Characteristics of acute cor pulmonale, except:
A) consequence of pulmonary embolism
B) consequence of severe acute asthma
C) echocardiography shows dilated, thin walled right ventricle
D) echocardiography shows hypertrophic dilated right ventricle
E) the consequence of acute increase of right ventricular pressure
D) echocardiography shows hypertrophic dilated right ventricle
In which condition could ’Birbeck’s granulomas’ be typically detected from bronchoalveolar lavage by electron microscopy or may be the ratio of CD1-positive cells above 3%?
A) alveolar microlithiasis
B) Goodpasture syndrome
C) Hamman-Rich syndrome
D) histiocytosis X
E) alveolar proteionosis
D) histiocytosis X
In which condition is pleural exudate most likely expected?
A) heart failure
B) nephrosis
C) cirrhosis hepatis
D) peritoneal dialysis
E) pulmonary embolism
E) pulmonary embolism
All of the following conditions may cause mediastinal lymph node enlargement, except:
A) Hodgkin’s disease
B) Non-Hodgkin’s lymphomas
C) Toxoplasma gondii infection
D) Sarcoidosis
E) Pneumonia
E) Pneumonia
Symptoms of superior vena cava syndrome, except:
A) swelling of the head
B) cyanosis
C) development of thoracic collateral circulation
D) arrhythmia
E) heavy breathing
D) arrhythmia
Characteristic of respiratory failure based on hypoventilation, except:
A) May be a consequence of neuromuscular disease
B) The degree of hypoxia is not similar to the degree of hypercapnia
C) May be caused by chest deformity
D) Ventilation pulmp failure
E) May be a consequence of obesity
B) The degree of hypoxia is not similar to the degree of hypercapnia
In the following conditions respiratory failure is predominantly due to diffusion failure, except:
A) fibrotic alveolitis
B) sarcoidosis
C) alveolar cell carcinoma
D) COPD
E) irradiation damage
D) COPD
Characteristic of trachea dyskinesis:
A) predispose to barking cough
B) common cause of cough
C) usually curable by surgery
D) precancerosis
E) relieved by antihistamines
A) predispose to barking cough
Which one of the following clinical signs is not characteristic of sleep apnea?
A) daytime sleepiness
B) intellectual- and personality changes
C) loud snoring at night
D) elevated blood glucose level
E) hypertonia
F) obesity
D) elevated blood glucose level
Tuberculosis infections can occur in the following ways, with one exception. Mark the exception.
A) trough airways
B) alimentary infection (by the consumption of contaminated food)
C) percutaneous (contact with the skin)
D) transplacental (through the placenta)
E) genital contact
D) transplacental (through the placenta)
Which one of the following can lead to chronic cor pulmonale?
A) lobar pneumonia
B) pulmonary venous thromboembolism
C) pulmonary edema
D) chronic obstructive pulmonary disease
E) bronchopneumonia
D) chronic obstructive pulmonary disease
Symptoms of Goodpasture-syndrome, except:
A) focal glomerulonephritis
B) septic spleen
C) pulmonary fibrosis, induration
D) cutaneous purpura
E) Prussian blue staining in lung parenchyma
B) septic spleen
All the followings are possible complications of chronic obstructive pulmonary disease (COPD), except:
A) cor pulmonale
B) polycythaemia
C) respiratory failure
D) left ventricular dysfunction
E) bronchogenic carcinoma
D) left ventricular dysfunction
Depending on the pathological changes in the lung, chronic obstructive pulmonary disease (COPD) can manifest as emphysema or bronchitis. Although these two COPD-syndromes rarely manifest as independent diseases, by definition they can be separated based on the clinical features. Which one of the following symptomes is common in both COPD’s bronchitic and emphysematous phenotype?
A) polycythaemia
B) airflow improvement with bronchodilators
C) dyspnoea
D) chronic cough
E) hypercapnia
C) dyspnoea
Which statement is not true about the autonomic innervation of the respiratory tract?
A) Parasympathetic nerves control the main mechanisms of bronchoconstriction.
B) Sympathetic nerves control the main mechanisms of bronchodilatation.
C) Acetylcholine is the primary mediator of parasympathetic postganglionic neurons.
D) Noradrenaline is the primary mediator of sympathetic postganglionic neurons.
E) Slightly increased cholinergic resting bronchial tone is physiological.
B) Sympathetic nerves control the main mechanisms of bronchodilatation.
Inhalation of non-selective cholinergic antagonists can paradoxically provocate bronchoconstriction. Inhibition of which receptor is responsible for this rare reaction?
A) M1
B) M2
C) M3
D) NA
E) Beta2-adrenergic
B) M2
How do anticholinergic bronchodilators exert their bronchial smooth muscle relaxing effect?
A) by facilitating sympathetic neuromuscular transmission
B) by inhibiting sympathetic neuromuscular transmission
C) by facilitating parasympathetic neuromuscular transmission
D) by inhibiting parasympathetic neuromuscular transmission
E) by direct effect
D) by inhibiting parasympathetic neuromuscular transmission
Which one of the following function is not characteristic of pulmonary surfactant?
A) stabilizing alveoli and bronchi during exspiration (anti-atelectasis)
B) maintaining the alveolo-bronchial clearance
C) enhancing alveolar macrophage function
D) enhancing the colonisation of particular viruses and bacteria
E) increasing bronchial clearance by reducing the adhesion between sol and gel phase of the fluid covering the bronchial walls
D) enhancing the colonisation of particular viruses and bacteria
Which statement is not true?
A) Alveoli can be found on the walls of bronchioles distal to the terminal bronchioles.
B) The terminal bronchiole is divided into two respiratory bronchioles.
C) The third-generation of respiratory bronchioles are divided into alveolar ducts.
D) Alveolar ducts can also originate from first-generation respiratory bronchioles.
E) Airways distal to the terminal bronchioles are called conductive airways.
E) Airways distal to the terminal bronchioles are called conductive airways.
Which statement is not true?
A) The average diameter of terminal bronchiole is 0,6 mm.
B) The wall of the bronchioles do not contain cartilage.
C) The lung unit provided by terminal bronchioles is called acinus.
D) The basis diameter of acinus is 0,5–1 cm.
E) The unit provided by the third-generation respiratory bronchioles is the terminal respiratory unit.
F) An acinus contains 8-10 lobules.
G) The average airspace of an acinus is 0,2 ml
F) An acinus contains 8-10 lobules.
The main features of cells, which cover airways, except for:
A) Clara cells are secretory cells, which do not contain cilium and are predominantly presented in the terminal bronchioles.
B) Kulchitsky cells produce biogenic amines.
C) Type I pneumocytes produce surfactant.
D) The number of goblet cells in the bronchi decreases towards the periphery.
E) In case of chronic irritation goblet cells may also appear in the bronchioles.
C) Type I pneumocytes produce surfactant.
Which statement is not true?
A) The average ventilation/perfusion ratio is 0,8.
B) Ventilation of basal areas is low compared to the perfusion.
C) Perfusion of apical areas is very low compared to the ventilation.
D) The normal alveolar ventilation is 8l.
E) Alveolar hypoventilation is characterized by the elevation of CO2 in the arterial blood.
D) The normal alveolar ventilation is 8l.
Which of the following metabolic functions does not occur in the lungs?
A) Production of prostaglandins
B) Production of arylsulphatase-B
C) Production of leukotrienes
D) Hormone production
E) Conversion of angiotensin I to angiotensin II
F) Hypoxaemia-induced erythropoietin production
G) Deamination of serotonine
H) Production of thromboplastin
F) Hypoxaemia-induced erythropoietin production
Which of the following cells plays a central role in the pathogenesis of bronchial asthma?
A) neutrophil granulocyte
B) eosinophil granulocyte
C) monocyte
D) histiocyte
E) plasma cell
B) eosinophil granulocyte
The most common stimulus which triggers exercise-induced asthma is:
A) running in cold air
B) using stationary bicycle
C) swimming
D) hall football
E) hall aerobic
A) running in cold air
Which of the following cells is the most important antigen presenting cell in asthma?
A) T-lymphocyte
B) alveolar macrophage
C) dendritic cell
D) epithel cell
E) endothel cell
C) dendritic cell
Which parameter goes first to normal range in case of the adequate treatment of community-acquired pneumonia?
A) fever
B) cough
C) auscultation
D) CRP
E) leukocytosis
D) CRP
Which virus can be the cause of pneumonia in transplanted patients and which one of the risk factors of rejection?
A) CMV
B) adenovirus
C) flu virus
D) EBV
E) RSV
A) CMV
The features of aspiration pneumonia are:
A) Community-acquired aspiration pneumonia is most commonly caused by aerob bacterias.
B) The clinical manifestation includes pneumonitis, necrotising bronchopneumonia and pulmonary abscess.
C) Leukocytosis is not a characteristic feature.
D) In diagnostic, the hemoculture has a main role because of its good sensitivity and specificity.
E) The first choice is aminoglycoside antibiotic treatment.
B) The clinical manifestation includes pneumonitis, necrotising bronchopneumonia and pulmonary abscess.
Which bacteria is NOT the cause of pulmonary gangraena?
A) Klebsiella pneumoniae
B) Anaerob bacterias
C) Mycobacterium marinum
D) Hemophilus influenzae
E) Staphylococcus aureus
C) Mycobacterium marinum
Which one of the followings is an exclusion criteria in lung transplantation?
A) idiopathic, non-treated, end-stage pulmonary disease
B) confused psychical status, unsettled severe social status
C) significantly reduced life expectancy without the surgery
D) acceptable nutritional status
E) severe pulmonary arterial hypertension
B) confused psychical status, unsettled severe social status
Which one of the followings is NOT the indication of lung transplantation?
A) end-stage pulmonary fibrosis
B) pulmonary sepsis
C) severe emphysema due to α-1 antitrypsin deficiency
D) pulmonary arterial hypertension
E) severe COPD with pulmonary hypertension
B) pulmonary sepsis
Which disease is not solved by lung transplantation alone?
A) Eisenmenger-syndrome
B) severe bilateral bronchiectasis with severe symptoms
C) pulmonary arterial hypertension
D) secundery pulmonary hypertension
A) Eisenmenger-syndrome
What situation can be an indication for combined heart and lung transplantation, if the adequate severity criteria are present?
A) congenital heart defect combined with Eisenmenger-syndrome
B) cystic fibrosis
C) severe emphysema caused by α-1 antitrypsin deficiency
D) end-stage pulmonary fibrosis
E) pulmonary arterial hypertension
A) congenital heart defect combined with Eisenmenger-syndrome
What is the chance of CMV pneumonia among lung transplanted patients without specific drug therapy?
A) 25%
B) 18%
C) 50%
D) 80%
E) 90%
C) 50%
When does the bacterial pneumonia occurs the most commonly after lung transplantation?
A) 0–3 months
B) 2–12 weeks
C) 1–3 months
D) 9 days –2 months
E) the first 2 weeks
A) 0–3 months