Pulmonology Flashcards
F/u for single solid lung nodule < 6mm with low risk factors
No f/u
F/u for single solid lung nodule < 6mm with high risk factors
CT 6-12 mo
F/u for multiple solid lung nodules < 6mm with low risk factors
No f/u
F/u for multiple solid lung nodule < 6mm with high risk factors
CT 6-12 mo
F/u for single ground glass and/or part solid lung nodule < 6mm
No f/u
F/u for single ground glass and/or part solid lung nodule > 6mm
CT 3-6 mo
GG: if no change, q2years x 5 years
PS: if no change, q1year x 5 years
Low FEV1 Low FEV1/FVC High TLC Low DLCO High RV
Emphysema (obstructive)
Low FEV1 Low FEV1/FVC High TLC Normal DLCO High RV
Bronchitis (obstructive)
Low FEV1 Low FEV1/FVC High TLC Normal DLCO Normal/High RV
Bronchiectasis (obstructive)
Low FEV1 Low FEV1/FVC High TLC Normal/high DLCO High RV
Asthma (obstructive)
Low FEV1 Normal FEV1/FVC Low TLC Low DLCO Low RV
Restrictive (intra-thoracic)
Low FEV1 Normal FEV1/FVC Low TLC Normal DLCO High RV
Restrictive (extra-thoracic)
Causes of high DLCO
More blood in alveoli
CHF MS ASD/VSD PDA Polycythemia Squatting Exercise Alveolar hemorrhage
Causes of low DLCO
Less blood in alveoli
COPD Restrictive disease PE pHTN Anemia Standing Valsalva
Causes of normal DLCO
Asthma
CO poisoning
Fixed extrathoracic obstruction (flat inspiratory and expiratory phase on flow loop)
Tumors
Tracheal stenosis
Dynamic extrathoracic obstruction (flat inspiratory phase on flow loop)
Epiglottitis
Obstruction
Vocal cord paralysis
Dynamic intrathoracic obstruction (flat expiratory phase on flow loop)
Intrathoracic tracheomalacia
Diagnose asthma with PFT/bronchodilators
FEV1 increases by 12% with bronchodilators
Diagnose asthma with methacholine challenge (bronchoprovocation test)
FEV1 drops by 20%
NSAIDs/ASA, nasal polyps, rhinitis
Management
Dx: Aspirin-exacerbated respiratory disease (aka aspirin induced asthma)
Tx: Montelukast, ICS
Management for asthma with high serum IgE levels
Add omalizumab
Management for asthma with high eosinophil count
IL-5 inhibitor (mepolizumab or beralizumab) - decreases exacerbation and improved FEV1
Management for asthma with high eosinophil count and resistance to PO corticosteroids
IL-4 inhibitor (dupilumab)
Diagnosing exercise induced asthma
Eucapnic voluntary hyperpnea challenge test - drop in FEV1 by 15%
Brownish mucus plugs
Gloves finger sign on CXR
+eosinophils
ABPA
BAL: CD8 > CD4
Ground glass appearance with no eosinophils
Hypersensitivity pneumonitis
Asthma
Weakness of right hand/foot
IgE elevated
Eosinophilic GPA
Recent immigrant
High eosinophils
CXR with round infiltrates
Management
Dx: Strongyloides infection (Loeffler’s syndrome)
Tx: Thiabendazole
Asthma
Very peripheral infiltrates
BAL: high eosinophils. High ESR
Management
Dx: Chronic eosinophilic pneumonia
Tx: chronic steroids
+eosinophils
Ground glass appearance on CXR
Management
Dx: acute eosinophilic pneumonia
Tx: steroids
Diffuse opacities (homogenous infiltrates) or ground glass appearance Tan colored fluid
Management
Dx: alveolar proteinosis
(Defective macrophages causing build up of surfactant in the lung)
Tx: whole lung ma age
GOLD stages for COPD
Gold 1: >80%
Gold 2: < 80%
Gold 3: < 50%
Gold 4: < 30%
COPD management per severity: A (low risk, less symptoms) B (Low risk, more symptoms) C (high risk, less symptoms) D (high risk, more symptoms)
A: SABA +/- SAMA
B: LAMA
C: LAMA
D: LAMA + LABA + ICS +/- PDE4 (roflumilast)
Adverse effect of Giotto policy in men > 60 y/o
Acute urinary retention
Criteria for starting O2 therapy in COPD
PaO2 < 55 mmHg or SpO2 < 88%
PaO2 < 59 mmHg or SpO2 < 89% with evidence of cor pulmonale, erythrocytosis (Hct > 55%)
Benefits of pulmonary rehab
Improvement in 6 min exercise endurance
Improvement in dyspnea and quality of life.
Trains muscles of ambulation
Management for COPD with FEV1 20-50% (despite pulm rehab) and bilateral upper lobe emphysema.
Lung volume reduction survey
Management for COPD with FEV1 < 20% (despite pulm rehab)
Lung transplant
Bilateral basal bullies cysts on CXR
Alpha-1 antitrypsin deficiency
Prominent cystic spaces in RLL and streaming opacities in the direction of bronchial tree (tram lines) on CXR
Bronchiectasis
Bronchiectasis
Sinusitis
Infertility
+/- situs inversus
Screening test
Dyskinetic cilia syndrome (Kartaganer syndrome)
Screening test: inhaled NO test
Confirmation test: biopsy of bronchi or sinus with video electron microscopy
Apical bullous changes on CXR
Cystic fibrosis
Leading bacteria that increases mortality in CF
Burkholderia cepecia
DOE
Severe obstruction
High/normal DLCO
No change with bronchodilator
Broncholitis obliterates
Associated with RA, carcinoid tumor, lung transplant
CXR with patchy of focal infiltrates with “organizing pattern”
Migratory infiltrates
Decreased DLCO
Management
Dx: Cryptogenic organizing pneumonia
Tx: steroids
Ankle pain
Hilary LAD
Non-caseating granulomas
BAL: CD4>CD8 (4:1)
Sarcoidosis
1) Random tree in bud pattern
2) Widespread tree in bud
3) consolidation with tree in bud
4) tree in bud dependent areas and esophageal abnormality
1) MAI/MTB
2) ABPA
3) aspiration bronchiolitis
4) aspiration bronchiolitis
Mechanics. Brake pads
Calcified plaques
Asbestosis
Sand blasting
Increased MTB incidence
Egg shell calcifications
Silicosis
Premenopausal
Pneumothorax
Honeycomb appearance
Chylous effusion
Lymphangiomyomatosis
Indications for thrombolytics
Acute massive PE
Large DVT, such as iliofemoral
Indications for IVC filter
H/o PE and another PE will cause death
Contraindication to anticoagulation
Emboli post-anticoagulation
Cirrhotic with PT/INR > 3.5 + DVT
S/p pneumonia treatment
Cough and Opacity persists
Underlying malingnancy
Recurrent pneumonia
CT with fibrosis
Post-obstructive pneumonia
Indications for Abx in sinusitis
Symptoms > 10 days
Fever/pain > 3 days
Sore throat, fever
Pain with swallowing and turning neck
Lemierre’s disease
Internal jugular vein thrombosis
Fusobacterium necrophorum
Mouth pain
Difficulty swallowing
Stiff neck with woody induration
Ludwig’s angina
Allergies made worse with medication (vasoconstrictors)
Rhinitis medicamentosa
Posterior RUL pneumonia
Klebsiella
RLL pneumonia
Strep
Adverse effects of fluoroquinolones
Prolong QTc
Tendon rupture
Paresthesias
Aortic aneurysms + dissection
Seizure
Upper lobe infiltrate
Peptostreptococcus
Ear pain, fever
Inflamed tympanic membrane
Mycoplasma
Fever, chest pain, cough
OCP
Management
Dx: pleurodynia due to coxsackie B virus
Tx: indomethacin
Management for influenza vaccine outbreak in nursing home
Vaccine + oseltamivir x 2 weeks
Nitrofurantoin
Crepitance over nasal lung fields
Ground glass appearance
Nitrofurantoin-induced pulmonary injury
Management for LTBI
INH and rifapentine weekly x 3 mo
Transudative pleural effusion
Total protein < 3g/dL
Fluid/serum protein ratio < 0.5
Total LDH < 200
Fluid/serum LDH ratio < 0.6
Milky pleural effusion
Triglycerides
Dull percussion
Decreased breath sounds
Absent VF/VR
Pleural effusion
Dull percussion
Bronchial breath sounds
Increased VF/VR
Pneumonia
Hyperresonant percussion
Decreased breath sounds
Decreased VF/VR
Pneumothorax
Orthodexia
Platypnea
Hepatopulmonary syndrome
Bubble study with < 4 heart beats
PFO or ASD
Bubble study with > 4 heart beats
Hepatopulmonary syndrome
SOB
Elevated left hemiduaphragm
Confirmation test
Dx: phrenic nerve injury
Confirmation test: fluoroscopic sniff test
Obesity
Elevated daytime PaCO2 and hypoxemia
Obesity hypoventilation syndrome
Abnormal respirations in CHF
Cheyenne-stokes
BAL results
1) increased neutrophils
2) increased lymphocytes
3) increased eosinophils
4) + silver methanamine
5) inclusion bodies
6) increased bacteria
7) foamy with lamellar inclusions
1) IPF
2) sarcoidosis (CD4>CD8); hypersensitivity pneumonitis (CD8>CD4)
3) Eosinophilic pneumonia
4) PJP
5) CMV
6) pneumonia
7) amiodarone
Light’s criteria
Exudative if either of the following:
Pleural/serum protein > 0.5
Pleural/serum LDH > 0.6
Pleural LDH >2/3 uln serum LDH
Transudative if ALL of above are met
Serum-pleural effusion protein difference > 3.1
OR
Serum-pleural effusion albumin gradient > 1.2
Transudative effusion
Therapies which prolong survival in COPD
Smoking cessation
Long-term O2 therapy (if resting PaO2 < 55 or SpO2 < 88% OR resting PaO2 < 59 or SpO2 < 89% + cor pulmonale or erythrocytosis)