Pulmonology Flashcards
F/u for single solid lung nodule < 6mm with low risk factors
No f/u
F/u for single solid lung nodule < 6mm with high risk factors
CT 6-12 mo
F/u for multiple solid lung nodules < 6mm with low risk factors
No f/u
F/u for multiple solid lung nodule < 6mm with high risk factors
CT 6-12 mo
F/u for single ground glass and/or part solid lung nodule < 6mm
No f/u
F/u for single ground glass and/or part solid lung nodule > 6mm
CT 3-6 mo
GG: if no change, q2years x 5 years
PS: if no change, q1year x 5 years
Low FEV1 Low FEV1/FVC High TLC Low DLCO High RV
Emphysema (obstructive)
Low FEV1 Low FEV1/FVC High TLC Normal DLCO High RV
Bronchitis (obstructive)
Low FEV1 Low FEV1/FVC High TLC Normal DLCO Normal/High RV
Bronchiectasis (obstructive)
Low FEV1 Low FEV1/FVC High TLC Normal/high DLCO High RV
Asthma (obstructive)
Low FEV1 Normal FEV1/FVC Low TLC Low DLCO Low RV
Restrictive (intra-thoracic)
Low FEV1 Normal FEV1/FVC Low TLC Normal DLCO High RV
Restrictive (extra-thoracic)
Causes of high DLCO
More blood in alveoli
CHF MS ASD/VSD PDA Polycythemia Squatting Exercise Alveolar hemorrhage
Causes of low DLCO
Less blood in alveoli
COPD Restrictive disease PE pHTN Anemia Standing Valsalva
Causes of normal DLCO
Asthma
CO poisoning
Fixed extrathoracic obstruction (flat inspiratory and expiratory phase on flow loop)
Tumors
Tracheal stenosis
Dynamic extrathoracic obstruction (flat inspiratory phase on flow loop)
Epiglottitis
Obstruction
Vocal cord paralysis
Dynamic intrathoracic obstruction (flat expiratory phase on flow loop)
Intrathoracic tracheomalacia
Diagnose asthma with PFT/bronchodilators
FEV1 increases by 12% with bronchodilators
Diagnose asthma with methacholine challenge (bronchoprovocation test)
FEV1 drops by 20%
NSAIDs/ASA, nasal polyps, rhinitis
Management
Dx: Aspirin-exacerbated respiratory disease (aka aspirin induced asthma)
Tx: Montelukast, ICS
Management for asthma with high serum IgE levels
Add omalizumab
Management for asthma with high eosinophil count
IL-5 inhibitor (mepolizumab or beralizumab) - decreases exacerbation and improved FEV1
Management for asthma with high eosinophil count and resistance to PO corticosteroids
IL-4 inhibitor (dupilumab)
Diagnosing exercise induced asthma
Eucapnic voluntary hyperpnea challenge test - drop in FEV1 by 15%
Brownish mucus plugs
Gloves finger sign on CXR
+eosinophils
ABPA
BAL: CD8 > CD4
Ground glass appearance with no eosinophils
Hypersensitivity pneumonitis
Asthma
Weakness of right hand/foot
IgE elevated
Eosinophilic GPA
Recent immigrant
High eosinophils
CXR with round infiltrates
Management
Dx: Strongyloides infection (Loeffler’s syndrome)
Tx: Thiabendazole
Asthma
Very peripheral infiltrates
BAL: high eosinophils. High ESR
Management
Dx: Chronic eosinophilic pneumonia
Tx: chronic steroids
+eosinophils
Ground glass appearance on CXR
Management
Dx: acute eosinophilic pneumonia
Tx: steroids
Diffuse opacities (homogenous infiltrates) or ground glass appearance Tan colored fluid
Management
Dx: alveolar proteinosis
(Defective macrophages causing build up of surfactant in the lung)
Tx: whole lung ma age
GOLD stages for COPD
Gold 1: >80%
Gold 2: < 80%
Gold 3: < 50%
Gold 4: < 30%