Neurology Flashcards
Contraindications to triptans (I.e. sumatriptan)
CAD
Vasculitis
Pregnancy
Management for refractory migraines (lasting > 72 hours)
IV prochlorperazine or metoclopramide + IV diphenhydramine
OR
IV Dihydroergotamine
Prophylaxis for migraines < 15x per month
Beta blockers
Topiramate
Valproate
Amitryptyline
Prophylaxis for migraines > 15x per month
1) Topiramate
2) Botox
Recurrent unilateral/retro-orbital headaches > 6-10x per day lasting 15-20 min.
Management
Dx: Chronic paroxysmal headaches
Tx: Indomethacin
Headache with obesity and vision problems and/or blurring of optic disc margins (papilledema).
Idiopathic intracranial hypertension
Management for trigeminal neuralgia
MRI Brain
Carbamazepine
Ptosis, miosis, anhydrosis
Compression if sympathetic chain (I.e. pancoast tumor - CXR; or carotid artery dissection - CTA neck)
Ptosis + mydriasis
Berry aneurysm compression of CN III
Optic nerve lesion
Ipsilateral complete blindness
Optic chiasm lesion
Bitemporal hemianopia
Optic tract lesion
Contralateral dense homonymous hemianopia
Optic radiation lesion
Contralateral homonymous quadrantanopia / dense hemianopia / macular sparing
Carotid artery syndrome
Ipsilateral visual loss
Contralateral motor or sensory changes
Vertebrobasilar syndrome
Dizziness
Diplopia
Dysarthria
Most important risk factor for stroke
Hypertension
Symptomatic with > 70% carotid artery stenosis
Carotid endarterectomy + ASA
Symptomatic with > 70% carotid artery stenosis and NOT surgical candidate
Transcarotid stent + ASA
Symptomatic with < 50% carotid artery stenosis
ASA
Asymptomatic with > 80% carotid artery stenosis
Carotid endarterectomy + ASA
Asymptomatic + total carotid artery occlusion
Medical management (collaterals present)
HTN, visual disturbances with hemianopsia/auras/cortical blindness. MRI brain with white matter edema in parietal-occipital region
Posterior reversible encephalopathy syndrome
Ipsilateral loss of pain/temp in face
Contralateral loss of pain/temp in body
Lateral medullary syndrome
Wallenberg syndrome - posterior inferior cerebella artery
Hemiparesis with involuntary shaking movements
Quadriplegia
Locked-in syndrome
Basilar artery stroke
Hyperdense lesion in parietal area suggestive of subarachnoid hematoma
Amyloid angiopathy
Management for subarachnoid hemorrhage
angiogram and endovascular clip
Management for Vasospasm In subarachnoid hemorrhage
Nimodipine
ONLY horizontal nystagmus
Peripheral vertigo
Peripheral vertigo + hearing loss
Labyrinthitis
Meniere’s disease
Veritgo, tinnitus +
1) fluctuating hearing loss
2) progressive hearing loss
1) Ménière’s disease
2) acoustic neuroma
Brain atrophy (enlarged sulci) on CT/MRI with dilated ventricles. Increased Beta amyloid. Telomere short lengthened.
Alzheimer’s disease (most common cause of dementia)
Management for Alzheimer’s
Mild (MMSE 21-25): anticholinesterase (donepezil, galantamine, rivastigmine)
Mod (MMSE 11-20): anticholinesterase + memantine (NMDA antagonist)
Severe (MMSE < 10): palliative
Adverse effects of cholinesterase inhibitors
Syncope
Bradycardia with increased PPM placement
Hip fracture
60 y/o. Cognitive impairment. Poor short-term memory. Can’t recall names. Paranoid delusions.
Alzheimer’s disease
Dementia with Visual hallucinations.
Cytoplasmic inclusion bodies and alpha-synuclein protein
Dementia with Lewis Bodies
Dementia
Hereditary
Choreiform movement
Huntington disease
Loss of interest. Disinhibition. Urinates on neighbors lawn. Hypersexual.
Frontotemporal dementia
Dementia.
Urinary incontinence.
Wide-based gait.
Enlarged ventricles. Not enlarged sulci
Normal pressure hydrocephalus
Internuclear ophthalmoplegia
Inability to addiction ipsilateral eye. Nystagmus of Contralateral abducting eye
Medial longitudinal fasciculus
Paresthesias
Vibration/position sense loss
Weakness, spasticity, hyperreflexia
Optic neuritis
Multiple sclerosis
demyelination of white matter
Management for acute relapse of Multiple sclerosis (INO, optic neuritis, functional impairment)
IV methylprednisolone 1g OD x 3-5 days
Check for JC antibodies prior to starting this.
Natalizumab
Resting pronation/supination tremor
Cog wheel rigidity
Retarded movement
Loss of reflex (frequent falls)
Parkinson’s disease
Decreased dopamine in substantia nigra
Adverse effects of levodopa
Involuntary movements
Psychiatric symptoms
On-off phenomenon (alternating hyper/hypokinesia
Management for on-off phenomenon with levodopa
Take with low protein meal
Increase dose/dosing frequency
consider adding selegiline/rasagiline
Antero-posterior flapping tremor
Exacerbates with anxiety
Alleviates with alcohol
Management
Dx: Essential tremor
Tx: propranolol. Then primidone
Progressive weakness throughout the day. Diplopia/ptosis. DTRs normal.
Myasthenia Gravis
Work-up for myasthenia gravis
1) Ach receptor Abs (post-synaptic)
2) nerve stimulation studies
3) CT chest (r/o thymoma)
Management for myasthenia crisis
1) PLEX
2) immunoglobulins
3) steroids
Weakness gets better with activity
Hyporeflexi
+ptosis
No diplopia
Lambert-Eaton syndrome
Only motor deficits
UMN and LMN lesions
Sensation intact
Management
Dx: ALS
Tx: Riluzole
LMN (UL weakness, starts in hands and moves proximal) and sensory (pain/temp sensation loss) changes
Syrinogomyelia
Cavitation of central spinal cord
Foot drop
Cannot invert foot
Cannot evert foot
L5 radiculopathy
Lumbar vertebral foramina
Foot drop
Can Invert foot
Cannot evert foot
Peroneal n. Injury
Fibular head
Management for foot drop with high steppage gait
Foot ankle orthosis
Etiology and management of spinal stenosis
Etiology: hypertrophy of ligamentum flavum
Tx: PT. Not surgery
CSF value in Guillain-Barré syndrome
Increased protein
Normal WBCs
Descending paralysis
Blurred vision, diplopia, dysarthria, dysphagia, diarrhea
Dilated pupils
Botulism toxicity
Extreme focal tenderness with light touch
Bluish discoloration
Complex regional pain syndrome
Reflex sympathetic dystrophy
Antiepileptic that causes kidney stones
Topiramate
Best AED with depression
Lamotrigine
AED that causes hyperammonemia
Valproate
Seizure with epigastric rising sensation, psychic sensation, deja vu
Focal unaltered awareness seizure (temporal lobe)
Seizure that spreads from UE to ipsilateral LE followed by weakness
Jacksonian seizure (frontal lobe)
Enhancing lesion
T cells < 50
Lymphoma
Ring enhancing lesion
Gray-white matter junction
Brain abscess
Multiple ring enhancing lesions
T cells < 100
Toxoplasmosis
Multiple non-enhancing lesions
T cells < 200
Progressive multifocal leukoencephalopathy
White matter plaques, enhance with activity
Multiple sclerosis
High frequency hearing loss
Presbycusis
Brachial plexopathy (lower) + Horners Syndrome
Cancer invasion
Brachial plexopathy (upper) + Paresthesias, fasciculations
Radiation injury