Pulmonary: Respiratory Drugs

Question 1

1st Generation H1 Blockers Drugs?

Answer 1

1st Generation H1 Blockers Drugs?

• Diphenhydramine
• Dimenhydrinate
• Chlopheniramine

Question 2

Clinical uses for 1st Generation H1 blockers?

Answer 2

• Allergies
• Motion sickness
• Sleep aid

Question 3

Toxicity of 1st Generation H1 blockers?

Answer 3

• Sedation
• Antimuscarinic
• Anti-α-adrenergic

Question 4

2nd Generation H1 Blockers Drugs?

Answer 4

2nd Generation H1 Blockers Drugs?

• Loratadine
• Fexofenadine
• Desloratadine
• Cetirizine

Question 5

Clinical uses for 2nd Generation H1 blockers?

Answer 5

• Allergies

Question 6

Toxicity of 2nd Generation H1 blockers?

Answer 6

• Far less Sedating than 1^st generation because of decreased entry into CNS

Question 7

Histimine (H1) Blockers Drugs?

Answer 7

Histimine (H₁) Blockers Drugs

• 1^st Generation
  
  • Diphenhydramine
  • Dimenhydrinate
  • Chlopheniramine
• 2^nd Generation
  
  • Loratadine
  • Fexofenadine
  • Desloratadine
  • Cetirizine

Question 8

Expectorant Drugs?

Answer 8

• Guaifenesin (expectorant)
• N-acetylcysteine (mucolytic)

Question 9

• Expectorant
• Thins respiratory secretions; does not suppress cough reflex

Answer 9

Guaifenesin

Question 10

• Mucolytic
• Can loosen mucous plugs in CF pts.
• Used as an Antidote for Acetaminophen Overdose

Answer 10

N-acetylcysteine

Question 11

• Antitussive (antagonizes NMDA glutamate receptors)
• Syntetic codeine analog
• Has mild opioid effect when used in excess
• Naloxone can be given for overdose
• Mild abuse potential

Answer 11

Dextromethorphan

Question 12

• Sympathomimetic α-agonistic nonprescription nasal decongestants
• Cx: Reduce Hyperemia, Edema, and Nasal congestion; Open obstructed Eustachian tubes. Pseudophedrine also illicityly used to make methamphetamine
• Toxicity: HTN, CNS stimulation/anxiety (Pseudoephedrine)

Answer 12

• Pseudoephedrine
• Phenylephrine