Pulmonary hypertension group 1

Question 1

CCB

Answer 1

for vasoreactive patients e.g. diltiazem, nifedipine, amlodipine

Question 2

For not vasoreactive patients

Answer 2

endothelin receptor antagonist
PDE-5 inhibitor
soluble guanylate cyclase stimulator
prostacyclin receptor agonist
prostacyclin analogues

Question 3

Endothelin receptor antagonist

Answer 3

macitentan
Cons: flushing, headache, nasal congestion, peripheral oedema
elevated hepatic aminotransferase

Question 4

PDE-5 inhibitors

Answer 4

slidenafil, tadalafil

Cons: headache, flushing, acid reflux, runny or stuffy nose

Question 5

soluble guanylate cyclase stimulators

Answer 5

riociguat

DO NOT use with PDE-5 inhibitor (hypotension)

Question 6

Prostacyclin analogue

Answer 6

improve pulmonary vascular resistance and platelet aggregation reduction
Epoprostenol: IV infusion
Treprostinil: IV infusion or subcutaneous injection
Iloprost: inhalation

Question 7

Prostacyclin receptor agonist

Answer 7

selexipag

Cons: headache, jaw pain, diarrhea