Pulmonary Hypertension Flashcards

Module 2B

1
Q

Pulmonary HTN occurs due to impaired function of

A

The right side of the heart

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2
Q

Pulmonary HTN describes

A

Increased pulmonary vascular resistance

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3
Q

What value should mPAP be at rest and with exercise?

A

Rest: >/=25
Exercise: 30

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4
Q

What is group 1 classification of pulmonary HTN?

A

Pulmonary arterial HTN (remodeling of small arteries)

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5
Q

What is group 2 classification of pulmonary HTN?

A

Pulmonary HTN with increased left sided heart pressure

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6
Q

What is group 3 classification of pulmonary HTN?

A

Associated with chronic lung disease and/or sleep apnea

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7
Q

What is group 4 classification of pulmonary HTN?

A

Chronic thromboembolic pulmonary HTN (multiple PEs)

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8
Q

What is group 5 classification of pulmonary HTN?

A

Pulmonary HTN secondary to disease process (hematologic, inflammatory, metabolic disorders)
Tumor obstruction, fibrosing mediastinitis, chronic renal failure on dialysis

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9
Q

What is the most common symptom of pulmonary HTN?

A

Dyspnea

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10
Q

What is the average time of diagnosis from the onset of symptoms?

A

1 year

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11
Q

What cardiac exam findings may be present?

A

Loud S2, tricuspid regurgitation and pulmonic regurgitation murmurs, decreased carotid pulse, lifts or heaves, loud S3 (right-sided), JVD, increased liver size, ascites, edema, tachyarrhythmias (Atrial flutter)

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12
Q

What are diagnostic imaging studies that should be ordered?

A

Chest x-ray, doppler studies, echo, CT or MRI, VQ scan

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13
Q

What are other diagnostic tests to consider?

A

Cardiac catheterization, PFT, ABG, BNP, biopsy

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14
Q

What condition is rare in the U.S. but is the leading cause of pulmonary HTN worldwide?

A

Schistosomiasis

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15
Q

What would an EKG reveal in pulmonary HTN?

A

S wave in lead I, Q wave in lead III, inverted T wave in lead III

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16
Q

Chronic right ventricular pressure overload can be seen on an EKG as

A

Right axis deviation, R wave:S wave of >1 in lead V1

17
Q

What are 4 drug categories used to manage pulmonary HTN?

A

CCBs, pristanoids, endothelia receptor antagonists, and phosphodiesterase inhibitors

18
Q

CCBs can be used to reduce

A

mPAP and pulmonary vascular resistance

19
Q

Prostanoids are used to induce

A

Vasodilation and prevent platelet aggregation/inflammation

20
Q

Prostanoids activate

A

Cyclic adenosine monophosphate

21
Q

Endothelin receptor antagonists are used to combat

A

Vasoconstriction and increase exercise capacity

22
Q

Phosphodiesterase inhibitors are used to

A

Increase pulmonary vascularization relaxation and decrease cellular proliferation

23
Q

What is an invasive procedure for pulmonary HTN?

A

Graded balloon dilation atrial septostomy