Pulmonary Gas Distribution Flashcards
What does a single breath N2 elimination test (SB N2) measure?
- evenness of distribution of inspired gases
- closing volume/closing capacity
What does phase I of closing volume/closing capacity represent?
deadspace (100% O2, no N2)
What does phase II of closing volume/closing capacity represent?
combination of deadspace and alveolar gases (N2 gases begin to increase)
What does phase III of closing volume/closing capacity represent?
alveolar gas
How is the evenness of gas distribution in phase III shown on the closing volume/closing capacity?
- mid-portion of the test is flat
- poor distribution slants up more
What is phase IV of the closing volume/closing capacity?
- shows a sudden rise in the N2%
- called the closing volume (airway closure)
- airway closure of dependent regions
- reason compression of lower airways
What is the closing capacity?
the adding of the closing volume to the RV
What other tests measure the distribution of gases?
ventilation scans
How is the closing volume affected with obstructive disease?
- closing volume is elevated
- slow of phase III is increased
What does DLCO stand for?
carbon monoxide diffusion capacity
What does DLCO measure?
- all the factors that affect the diffusion of a gas across the A-C membrane
- measured in ml/min/mmHg
What is normal DLCO?
25 mL/min/mmHg
What factors affect DLCO?
- Hb, Hct
- body position
- breath holding time
- lung volume
- smoking
What does an increase in eosinophils cause?
increase in inflammation
What does decreased DLCO occur in?
- pulmonary fibrosis
- sarcoidosis
- ARDS
- edema