Pulmonary Exam I Flashcards
Majority of resistance to breathing is within the first ____ generations
10
- cross sectional area increases farther down the bronchial tree
How many generations make up the conducting zone?
0-16
- starts from the trachea (0) and ends at the terminal bronchioles (16)
Where is cartilaginous support found in the airway?
trachea and subsegmental bronchi (4-9)
Conducting Airway Layers
(picture)
Ciliated pseudostratified epithelia

Cilia
propel debris and foreign particles toward glottis
- found in conducting zone
- moves mucus 2cm/min
- works with Nexin
Goblet Cells
produce mucus in conducting zone
- 100 mL of mucus a day
- viscoelastic
- deforms and spread when force is applied to it
- innervated by parasympathetic NS (Vagus)
Clara Cells
secretory in bronchioles and beyond
- conducting zone
- proteins, inflammatory modulators
Mast Cells
contains inflammatory mediators of conducting zone
- histamine, lyosomal enzymes, met.
Bronchial Glands
exocrine glands controlled by the parasympathetic NS
Respiratory Bronchiole
- squamous cell
- some ciliated
- no goblet cells or smooth muscle
- alveoli in walls
Alveolar Ducts
- walls made of alveoli
- each opens into 10-15 alveoli
When do you stop making alveoli?
8-10 years old
Approximately how many alveoli are in an adult?
300 million
- up to 280 billion pulmonary capillaries
- SA for gas exchange is about 70m2
Pore of Kohn
holes in the walls of adjacent alveoli
- allows air to move between alveoli
Type I Alveolar Cells
really flat squamous epithelia
- 250 um wide
Type II Alveolar Cells
manufacture and store sufactant
- contains phospholipids
- decrease surface tension of alveolus
Canals of Lambert
openings to a second respiratory bronchiole
Pathway for Gas Exchange
- oxygen inside alveolus
- surfactant
- type I cell (wall)
- basement membrane
- interstital space
- capillary wall (endothelium)
- plasma
- erythrocyte
Inhalation
expanding chest generates negative pressure
- Diaphragm and external intercostals
Accessory muscles of inhalation
sternocleidomastoid, scalenes, and pectoralis
Muscles of Exhalation
abdominals and internal intercostals
Pleural space
virtual space that contains fluid to reduce friction
- links motion of chest wall and lungs
- negative pressure
Resting position of chest wall
negative intrathoracic pressure is required to keep it from expanding to its resting position
- usually greater than its dimensions in vivo
What keeps the chest wall from expanding further?
negative pleural pressure
Transmural pressure
unequal pressures on either side of structure define expanion or compression
Pinside - Poutside
- positive: forces that expand of increase volume
- negative: collapsing forces or decrease volume
- zero value: unstressed, resting position
End Expiration and During Inspiration
(pictture)

Respiratory compliance
lung and thoracic cage are in series
1/total = 1/lung + 1/chest wall
- for a supine paralyzed patient:
- 1/0.85 = 1/1.5 + 1/2
Normal value of lung compliance
150 mL/cmH2O
(1. 5 k/kPa)
* stiff lungs have a low compliance
Compliance curve of lung
(picture)

Factors in elastic recoil of lung
Mainly the surface tension at the alveolar gas-liquid interface
some from tissue elastic forces of lung and chest wall
LaPlace’s Law
P = 2T/R
Pulmonary surfactant
produced by type II and stored in lamellar bodies
- 90% lipids
- 10% proteins
- albumin and globulin
- 2% surfactant proteins
- Mono or multi- layer structure
- 5-30 dynes/cm
- compaired to 72 in water
Surfactant deficiency
decreases compliance of lungs
- needs a greater inflation pressure to keep alveoli open
- areas of atelectasis
- fluid filled alveoli
Functional Residual Capacity
when outward expansion of chest wall counter balances the collapsing force of the lungs
- resting equilibrium point
Normal value of thoracic cage compliance
200mL/cmH2O
FRC as a function of body position
(picture)

FRC in disease states
(picture)

Which generation of bronchi have the highest total resistance?
5th-7th
PNS stimulation of bronchial smooth muscle
constriction and secretions
What constricts the airway?
- Paraysmpathetic stimulation
- acetylcholine
- histamine
- leukotrienes
- thromboxane A2
- serotonin
- alpha agonists
- decrease PCO2 in small airways
What dilates the airway?
- sympathetic stimulation
- Beta receptors
- Beta-2 agonists
- nitric oxide
- increase PCO2 in small airways
- decreased PO2 in small airways
Abdominal contraction effects in forced exhalation
- increase:
- intrathoracic pressure
- pleural pressure
- alvevolar pressure
Dynamic compression of airway
- amount able to be forced out is independent of effort
- increase in pleural pressure is transmitted to airway and alveoli
- flow limitation
Flow-Volume Loop
(picture)

Obstructive Diseases
asthma and COPD
- decreased elastic recoil
- reduction in alveolar pressure
- earlier collapse of airways
Normal vs. Obstructive flow-volume
(picture)
Emphysema

Spirometry
(picture)

Amount in Lung Volumes and Capacities
- Total Lung Capacity
- 6.0L
- Inspiratory Capacity
- 3.0L
- Functional Residual Capacity
- 3.0L
- Inspiratory Reserve Volume
- 2.5L
- Tidal Volume
- 0.5L
- Expiratory Reserve Volume
- 1.5L
- Residual Volume
- 1.5L
- Vital Capacity
- 4.5L
What values cannot be determined with spirometry?
TLC, FRC, and RV
Helium Dilution Techinque for Spirometry
C1V1 = C2V2
FRC = V2 - V1
- helilum is not absobed into the blood so it stays in the alveoli
- underestimated number bevause it only measures central airways
Pt has circuit volume of 5000ml
Initial concentration of He is 10% in gas
Final concentration of circuit + FRC is 8%
What is FRC?
V1C1 = V2C2
(5000 * 0.10) = (0.08)V2
V2 = 6250mL
FRC = V2 - V1 = 6250 - 5000 = 1250mL
Boyle’s Law
P1V1 = P2V2
(at constant temperature)
Factors that Influence Dead Space
- Size
- Age
- Neonate (3.3mL/kg)
- adult (2mL/kg)
- Posture
- sitting > supine
- Neck/jaw position
- extended > flexed
- Lung volume
- higher volume = more dead space
- Tracheal intubation
- eliminates 1/2 but adds apparatus, so often the same
- Tidal Volume and RR
- decrease tidal volume decreases deadspace due to laminar flow
- decreased RR decreases deadspace
Bohr Equation
Ratio of dead space to total tidal volume
VD/VT = (PaCO2 - PECPO2) / PaCO2
- VD/VT is usually around 0.3
- VA = (VT - VD) * RR
During anesthesia, does the ration of dead space to tidal volume increase or decrease?
increase
Alveolar ventilation and CO2 Production
K = arterial partial pressure of CO2
- alveolar ventilation is proportional to CO2 production and inversely proportional to pressure of CO2


- transmural pressure is higher at the apex of the lung
- alveoli at apex are less compliant
Awake vs. Anesthetized distribution of ventilation in lateral decubitus
Down > Up when awake
Up > Down when anesthetized
Closing Capacity
closing volume + residual volume
- independent of body position
- When FRC is less than closing capacity, some of the pulmonary blood will be distributed to alveoli with closed airways, usually in the dependent part of the lung, which will constitute a shunt and will increase the P(A-a) gradient
Closing Capacity and Volume
Closing capacity occurs when dependent airways begin to close as lung volume decreases
- closing capacity increases with age
- pleural pressure is becoming less negative

Gas Trapping
occurs when the airway collapses during exhalation and gas becomes trapped behind
- increased FRC and RV
- due to less transmural pressure
When closing capacity is higher than FRC
early airway closure and gas not being exchanged
- occurs when supine and anesthetized
How can you prevent gas trapping?
CPAP, PEEP, pursed lip breathing
Time constant of inflation
Time constant = resistance * compliance
- time required for inflation of lung if the inital flow rate were maintained
- 1st time constant = 63% inflatted
Equal time constants
pressure build up will be identical during inflation
- distribution of ventilation is not dependent on rate, duration, or frequency
- NO redistribution of gas
Ex: flat expiratory waveform
(although not necessarily uniform ventilation)
Differing Time Constant
- distribution of ventilation depends on rate, duration, and frequency
- dynmaic compliance is decreased with increasing frequency
- Redistribution of gas occurs
Ex: upsloping EtCO2 waveform
Vd/Vt calculations for a 70kg patient
- 600mL breaths * 15 RR
- 300mL breaths * 25 RR
- 1000mL breaths * 8 RR
Calculate minute ventilation and alveolar ventilation
(assume a normal Vd/Vt ratio of 0.3)
- 6300
- 5250
- 5600
CO from left heart
pulmonary blood flow
6-25 L/min
Pulmonary Vascular Resistance (PVR) equation
PA pressure - left atrial pressure
CO
Zone 1 of the Lung
Palv > Pa > Pv
- apex of the lung
- little to no flow of blood to this regin
- capillaries are flattened by pressure in alveolus
- does not occur in normal conditions
Zone 2 of the Lung
Pa > Palv > Pv
- some blood flow because arterial is greater than alveolar but this acts like a Starling resistor
Zone 3 of the Lung
Pa > Pv > Palv
- flow is determined by arterial-venous pressure difference
- no influence of alveolar pressure

Overall pulmonary vascular resistance
solid line is total PVR
- at FRC, pulmonary vascular resistance is minimal

Hypoxic Pulmonary Vasoconstriction (HPV)
stimulated by a decrease in PAO2 or mixed venous PO2
- affects primarily small arterioles
- chronic HPV leads to pulmonary hypertension
What inhibits HPV
prostacyclin and NO
What endothelial mediators increase HPV
thromboxane and endothelin
SNS control of PVR
(adrenergic)
- T1-T5 nerves
- alpha-1 agonism
- vasoconstriction
- Beta-2 agonist
- vasodilation (epi)
PNS control of PVR
(cholinergic)
- vagus
- M3 vasodilation
- Endothelilum and NO dependent
Humoral Control of PVR
- Catecholamines
- mostly constriciton
- Prostaglandin, arachidonic acid, leukotrienes, and thromboxane
- vasoconstrictor
- prostacyclin
- vasodilator
- histamine
- vasodilates during Epi constriction
- constricts bronchials
- Serotonin
- constriction
Secondary Pulomonary Hypertension
due to chronic hypodia or lung disease
- leads to right sided heart failure
- hard to treat
- non-specificity of pulmonary receptors
- drugs that treat increased PVR may abolish HPV
Nitric Oxide on Pulmonary Circulation
- pulmonary dilator
- increase V/Q matching
- immunomodulator (decrease inflammation)
- rapidly activated Hb
Side effects:
- short duration
- rebound effect
Prostacyclin Derivatives
(epoprostenol, treprostinil, iloprost, cisaprost)
induces relaxation of VSM
- increase production of cAMP
- inhibits growth of smooth-muscle cells
ACE inhibitors on Pulmonary Circulation
decrease PVR and vascular remodeling
ARBs on Pulmonary Circulation
decrease PAP with no increase in hypoxia
Phosphodiesterase inhibitors on Pulmonary Circulation
(amrinon and milrinone)
- slows breakdown of cAMP
- smooth muscle relaxation
CCB on Pulmonary Circulation
- relaxation
- may worsen hypoxemia
- large doses often needed to affect pulmonary hypertension
Endothelin Antagonists on Pulmonary Circulation
(Ambrisentan)
effective in chronic hypoxia and pulmonary hypertension
Pulmonary System Pressures
Right ventricle: 25/0
Pulmonary Artery: 25/8
Pulmonary Catheter: 7mmHg (mean)
Left Atrial: 5mmHg (indirect)
Driving pressure is (PAP - PVP)/LAP

typical resting value for alveolar ventilation
4 L/min
resting value for pulmonary blood flow
5 L/min
Ventilation and Perfusion in Lung
(picture)

Variations in regional alveolar ventilation
(picture)

Absolute Shunts
venous blood flow to totally non-ventilated alveoli
Ex: PE or one-lung ventilation
Pathological Shunt
tetraology of fallot
(right to left flow)
Capillary Content of Oxygen (CcO2)
CcO2 = (1.31)(Hb)(SAO2) + (0.003*PAO2)
Arterial Oxygen content (CaO2)
CaO2 = (1.31)(Hb)(SaO2) + (0.003*PaO2)
Mixed venous oxygen content (CvO2)
CvO2 = (1.31)(Hb)(SvO2) + (0.003*PvO2)
Partial pressure of Oxygen in the alveolus in ventilated lung
PAO2 = FiO2 * (Patm - PH2O) - (PaCO2/R)
- PH2O = 47
- R = 0.8
Alveolar pressure of Oxygen (PAO2)
PAO2 = PIO2 - (PaCO2/RQ)
healthy young patient at rest, what is the correct calculation and result for their partial pressure of oxygen in their alveolus?
(760-47)*0.21 – 40/0.8
Calculating Shunt Fraction (Qs/Qt)
(CcO2 - CaO2) / (CcO2 - CvO2)
Patient with a Hb of 15mg/dL, breathing room air at sea level. PAO2 of 100mmHg
CcO2 = (1.31)(15)(1.0) +( .003)(100)=20 ml/dL
CaO2 = (1.31)(15)(.90) + (.003)(90)= 17.87 ml/dL
CvO2 = (1.31)(15)(.75)+(.003)(40)= 14.86 ml/dL
Qs/Qt = 20 – 17.87 / 20 – 14.86 = 41.44% shunt fraction
A-a Difference
alveolar to arterial oxygen partial pressure difference
PAO2 - PaO2
- increases in A-a difference is due to problems with gas exchange
- V/Q mismatch
- True shunt
Assuming normal values for Hb, PCO2 and a-v content difference, the arterial PO2 is determined mainly by _____
FiO2
MIGET
multiple inert gas elimination technique
- six tracer gases with different solubilities
- retention and elimination are related to solubility coefficient of each tracer
V/Q ratios in Disease
(picture)
COPD Asthma
COPD w/ emphysema After Bronchodilator

accessory muscles of inhalation include
sternocleidomastoid, serratus anterior, pec major