Pulmonary Flashcards

1
Q

steeple sign on XR of neck =

A

croup

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2
Q

Lateral XR of neck with thumbprint sign =

A

epiglottitis

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3
Q

Infection that causes acute bronchitis

A

most often viral - RSV, Rhinovirus, Influenza

5-10% bacterial

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4
Q

I came in to see my physician assistant because of…

SOB, wheezing, cough 3+ weeks

A

acute bronchitis

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5
Q

XR findings of acute bronchitis

A

hyperinflation of lungs

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6
Q

Acute bronchitis treatment

A

H. flu vaccine

Supportive care including fluids, rest, use of humidifier

Antibiotics should play a small role here

Smoking cessation

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7
Q

What type of patient gets acute bronchiolitis?

A

children under 2 yo

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8
Q

Acute bronchiolitis most commonly caused by what infection?

A

RSV

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9
Q

PE findings of child with acute bronchiolitis

A

crackles, wheezing
elevated respiratory rate

signs of respiratory distress - chest wall retractions, accessory muscle use, nasal flaring

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10
Q

Acute bronchiolitis treatment

A

Supportive care: Humidifier, fluids, nebulized Albuterol or epinephrine

Self limiting

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11
Q

I came in to see my physician assistant because my child is…

Difficulty swallowing
Drooling
Hoarseness
Stridor

A

epiglottitis

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12
Q

Most common cause of epiglottitis

A

H-flu (prevent with vaccine)

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13
Q

Best abx to treat epiglottitis

A

2nd or 3rd gen cephalosporin (Cefuroxime or Ceftriaxone/Rocephin)

Clindamycin or Erythromycin

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14
Q

I came in to see my PA because my child…

Low grade fever
Congestion
Cough
Stridor
Barking or seal-like cough
A

Croup

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15
Q

Most common causes of croup

A

Parainfluenza, RSV, Rhinovirus

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16
Q

Croup treatment

A

Nebulized epinephrine for severe cases

Alway administer oral steroids

Supportive care

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17
Q

Treatment of influenza

A

Influenza vaccination
Supportive care
Ribavirin aerosolized
Zanamivir and oseltamivir (expensive, must be started within 48 hrs of infection)

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18
Q

Child with rapid consecutive coughs followed by a deep inspiration with characteristic high pitched whoop

A

pertussis

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19
Q

Pertussis treatment

A

Vaccination available as Tdap

Macrolides: Erythromycin or Azithromycin

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20
Q

The most common cause of lower respiratory infection in children and in immunocompromised

A

RSV

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21
Q

Indications for Ribavirin

A

severe RSV infections in high risk patients

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22
Q

Risk factors for TB

A

overcrowding, malnutrition, smoking, DM, HIV

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23
Q

I came in to see my physician assistant because of…

Chronic productive cough with blood tinged sputum
Fever
Drenching night sweats
Weight loss

A

Tuberculosis

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24
Q

What are positive results of TB skin test?

A

Normal healthy low risk person positive test at 15 mm of induration

Healthcare worker or moderate risk patient positive at 10 mm

Immunocompromised patients considered positive at 5 mm

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25
Q

How is TB diagnosed with labs and imaging?

A

TB skin test
Chest XR (apical/upper opacities)
Acid fast bacillus stain of sputum
Culture? (but slow growing, 2-6 wks)

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26
Q

Medical therapy for TB

A

Initial 6 or 9 month course of four antibiotics

Isoniazid(INH)
Rifampin
Pyrazinamide
Ethambutol

Once antibiotic sensitivities are complete patients usually continue on isoniazid and rifampin for at least 4 more months

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27
Q

Side effects of TB medications

A

Isoniazid: peripheral neuropathy, hepatitis, rash

Rifampin: orange body fluids, flu like symptoms, hepatitis

Pyrazinamide: arthralgias, hepatitis

Ethambutol: optic neuritis

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28
Q

hot potato voice =

A

epiglottitis or peritonsillar abscess

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29
Q

Pulmonary disease associated with caves and bird or bat droppings

A

histoplasmosis

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30
Q

About half of CAP cases are caused by what? Other causes?

A

strep pneumo

H flu, staph aureus, Klebsiella, influenza, RSV

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31
Q

PE findings of pneumonia

A

crackles
dullness to percussion
bronchial breath sounds

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32
Q

Chest XR findings of pneumonia

A

lobar consolidation
air bronchograms
pleural effusions

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33
Q

Treatment of community-aquired pneumonia

A

macrolides (erythromycin) or doxycycline

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34
Q

What is common name for atypical community acquired pneumonia?

A

walking pneumonia

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35
Q

How does atypical CAP present differently?

A

Variable symptoms
Little or no finding on PE
Chest XR with diffuse infiltrates

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36
Q

Criteria to diagnose nosocomial pneumonia

A

pneumonia after 48 hrs in hospital

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37
Q

Most common cause of nosocomial pneumonia? Most common cause in ICU?

A

G- bacillus and staph aureus

ICU is Pseudomonas

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38
Q

Immunocompromised patients with SOB and cough, should be treated for what?

A

pneumocystis pneumonia (pneumocystis jirovecii)

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39
Q

Complication of pneumocystis pneumonia

A

pneumothorax

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40
Q

Chest XR findings of pneumocystis pneumonia

A

diffuse interstitial infiltrates (ground glass appearance)

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41
Q

Best lab to eval severity of pneumonias

A

ABG (shows hypoxia)

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42
Q

Pneumocystis pneumonia treatment

A

TMP-SMX (Bactrim)

+/- steroid for alveoli inflammation

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43
Q

Histoplasmosis treatment

A

ANTI-FUNGAL

Oral Itraconazole or Amphotericin B for a few months and for prophylaxis

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44
Q

Tidal volume

A

volume of air moved into and out of lungs during normal resting respirations

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45
Q

Vital capacity

A

volume of air exhaled slowly after the deepest inspiration possible

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46
Q

What does spirometry measure?

A

volume and speed of exhalation and inspiration

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47
Q

forced vital capacity (FVC)

A

volume of air forcefully exhaled after deepest breath possible

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48
Q

FEV 1

A

volume of air forcefully exhaled in 1 second

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49
Q

Peak expiratory flow rate (PEFR)

A

highest airflow rate during forced expiration

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50
Q

Bronchospasm leading to airflow obstruction

A

asthma

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51
Q

What is the atopic triad?

A

asthma, atopic dermatitis (eczema), allergic rhinitis

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52
Q

What is a paradoxical pulse? Seen in what pulmonary pathology?

A

pulse that is weaker during inhalation and stronger during exhalations

seen during asthma exacerbation

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53
Q

Spirometry results of asthma

A

decreased FEV1 and PEFR (both improved with bronchodilator)

normal FVC

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54
Q

What other pulmonary function tests can be done if spirometry is not effective?

A

histamine or methacholine challenge

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55
Q

How are severities of asthma classified?

A

Intermittent

  • Two or less episodes per week
  • Two or less nighttime episodes per month

Mild persistent

  • More than two episodes per week
  • Three to four nighttime episodes per month

Moderate persistent

  • Daily episodes
  • One nighttime episodes per week

Severe persistent

  • Symptoms continuous
  • Night time episodes almost every night
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56
Q

Chronic treatment of intermittent and persistent asthma?

A

intermittent: SABA

mild persistent: SABA + daily low dose ICS

mod persistent: SABA + daily medium dose ICS + daily LABA

severe persistent: SABA + daily high dose ICS + daily LABA + systemic steroids

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57
Q

Most commonly used SABA, ICS, and LABA for asthma treatment

A

SABA - Albuterol
ICS - Beclomethasone
LABA - Salmeterol

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58
Q

Acute treatment of asthma exacerbation?

A

SABA
oxygen prn
consider upping steroid or using anticholinergic

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59
Q

What two conditions are under COPD umbrella?

A

chronic bronchitis

emphysema

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60
Q

Number one cause of COPD

A

smoking

61
Q

Differences between chronic bronchitis and emphysema

A

chronic bronchitis = “blue bloaters”
bronchi inflammation
productive cough, more hypoxic, larger air volume due to more trapped air

emphysema = “pink puffers”
alveoli collapse
dry cough, less hypoxic and more accessory muscle use, hyperventilation

62
Q

Diagnostic criteria of COPD cough

A

3 consecutive months per year in 2 consecutive years

63
Q

Pulmonary function test results of COPD

A

FEV1 decreased
FEV1/FVC decreased
Increased lung volume due to air trapping

64
Q

Pulm findings on PE of COPD

A

diminished breath sounds
+/- rhonchi in chronic bronchitis
wheezing

65
Q

Chest XR findings of COPD

A

hyperinflation with flat diaphragm

emphysema - parenchymal bullae, subpleural blebs

66
Q

COPD treatment

A

Stop smoking!

Antibiotics due to repeated infections

SABA (albuterol)

Anticholinergics (ipratropium)

Inhaled steroids (budesonide)

Oral steroid

Oxygen is only medication that changes course of severe COPD

67
Q

Best diagnostic test for cystic fibrosis

A

chloride sweat test showing elevated NaCl

68
Q

Pathophysiology and etiology of cystic fibrosis

A

Autosomal recessive disease caused by mutation of CFTR protein

This causes viscous mucus leading to recurrent pulm infections, pancreatic insufficiency (malabsorption), biliary obstruction, intestinal obstruction

69
Q

cystic fibrosis findings on lung exam

A

hyperresonance to percussion, apical crackles

70
Q

PFT results of cystic fibrosis

A

total lung capacity decreased

71
Q

Common complaints of patient with cystic fibrosis

A
chronic lung issues
recurrent sinusitis
diarrhea, abd pain
poor growth and weight gain
infertility
72
Q

Cystic fibrosis treatment

A
Chest and back percussion
DNAse enzyme to break down mucus
Bronchodilators
Inhaled hypertonic saline
Antibiotics for recurrent infection
Dietary supplements
Pancreatic enzyme replacement
73
Q

Irreversible dilation of the bronchial tubes caused by destruction of the tissue

A

Bronchiectasis

74
Q

50% of bronchiectasis cases are caused by ________.

A

cystic fibrosis

75
Q

Chest XR findings of bronchiectasis

A

Tram tracks or ring like markings – dilated thickened bronchi

Atelectasis

76
Q

Bronchiectasis treatment

A

Prophylactic antibiotics may be necessary

Surgical resection if disease is found all in one area

77
Q

Chest XR with parenchymal bullae, subpleural blebs

A

emphysema

78
Q

Types of obstructive pulmonary diseases

A

Asthma
COPD (chronic bronchitis, emphysema)
Cystic fibrosis
Bronchiectasis

79
Q

All obstructive pulmonary diseases have what finding on chest XR?

A

hyperinflation of lung fields

80
Q

Types of restrictive pulmonary diseases

A

Idiopathic pulmonary fibrosis
Pneumoconiosis
Sarcoidosis
Pleural diseases

81
Q

Dry cough
Dyspnea
Fine crackles at bases may be present
Lung volumes are reduced

A

Idiopathic pulmonary fibrosis

82
Q

Idiopathic pulmonary fibrosis treatment

A

Prednisone may help

Oxygen improves symptoms

Lung transplant

83
Q

Group of diseases which are restrictive and caused by inhalation of specific types of dust.

A

Pneumoconiosis

84
Q

nodules in middle and upper lung fields with eggshell calcifications

A

Silicosis or asbestosis

85
Q

This is the development of scar tissue within the lungs

A

Idiopathic pulmonary fibrosis

86
Q

nodular opacities in upper lung fields. Eggshell calcifications

A

coal miners lung

87
Q

Pulmonary function test results of restrictive pulmonary diseases

A

FEV1 is reduced
FVC is reduced
Lung volumes are reduced

88
Q

Treatment of any pneumoconiosis

A

Oxygen will alleviate symptoms

Do not smoke!

Avoid dust of any type

89
Q

inflammatory disease which is characterized by granulomas throughout the body

A

Sarcoidosis

90
Q

Chest XR of sarcoidosis

A

Hilar adenopathy

Nodules or infiltrates in the parenchyma as in later disease

91
Q

Pathophysiology of pleural effusion

A

Excess fluid between the pleural layers which limits breathing by limiting the ability of the lungs to expand

92
Q

How is US guided thoracentesis useful in evaluating pleural effusion?

A

Find out the cause of effusion

exudative fluid (inflammation) = pneumonia
transudative fluid = CHF, cirrhosis
93
Q

Sarcoidosis treatment

A

In most cases observation is first step

Corticosteroids

94
Q

What is egophony? When is it positive?

A

on auscultation an E sounds like an A, indicating consolidation

Pleural effusion, pneumonia, idiopathic pulmonary fibrosis

95
Q

What does dullness to percussion and diminished breath sounds indicate?

A

fluid in lungs

96
Q

What do you hear on auscultation of pleural effusion?

A

diminished breath sounds

pleural friction rub

97
Q

Pleural effusion treatment

A

Antibiotics if appropriate

Therapeutic thoracentesis

Chest tube placement

Pleurodesis – obliteration of the pleural space

98
Q

What is a pneumothorax?

A

air or gas in the pleural space which will limit the lungs ability to expand

99
Q

Biopsy showing non-caseating granulomas? Caseating granulomas?

A

Noncaseating = Sarcoidosis

Caseating = TB

100
Q

What type of person is at risk for primary pneumothorax (no underlying lung disease)?

A

Smokers

Young, tall, thin males

101
Q

Causes of secondary pneumothorax

A

Underlying lung disease - COPD, asthma, cystic fibrosis, TB, etc.

102
Q

Hallmark CXR finding of tension pneumothorax

A

contralateral mediastinal shift

103
Q

Visceral pleural line on CXR is diagnostic of ______.

A

pneumothorax

104
Q

Pneumothorax treatment

A

A small primary pneumothorax (10-15% of hemithorax involvement) may be watched and will likely resolve on its own

Chest tube is definitive therapy for larger pneumothorax or tension pneumothorax

Pleurodesis - obliteration of the pleural space

105
Q

What is Cor Pulmonale?

A

Right-sided heart failure secondary to severe pulmonary disease

106
Q

EKG and CXR findings of cor pulmonale

A

EKG: tall peaked T waves, right axis deviation

XR: enlarged R ventricle, enlarged pulm artery

107
Q

PE signs of right sided heart failure

A

cyanosis, peripheral edema, ascites, increased JVD

108
Q

Treatment of right sided heart failure and cor pulmonale?

A
  • Treat the underlying lung disease
  • Oxygen
  • Diuretics as well as salt and fluid restriction
109
Q

___________ is a blockage of a main artery into the lungs by something that has traveled from somewhere else in the circulatory system.

A

Pulmonary embolism

110
Q

What is Virchow’s triad?

A

risk factors of pulmonary embolism

  1. Immobility
  2. Hypercoagable state
  3. Vessel injury
111
Q

How should pulmonary embolism be imaged?

A

CXR, Helical CT, pulmonary angiography

112
Q

EKG of pulmonary embolism

A

sinus tachycardia most common finding

S1Q3T3 pattern in 10%

113
Q

How to treat pulmonary embolism?

A

Anticoagulation x 6-12 months; Heparin immediately, Warfarin long term

Thrombolytics

Inferior vena cava filter

Embolectomy

114
Q

CXR showing Westermark sign and Hampton hump

A

pulmonary embolism

115
Q

What test can rule out pulmonary embolism?

A

Normal VQ scan

116
Q

right sided heart failure with splitting of S2 and exertional syncope

A

pulmonary HTN

117
Q

Gold Standard for pulmonary HTN diagnosis

A

right heart catheterizations

118
Q

Pulmonary HTN management

A

Treat underlying cause

Anticoagulants – warfarin

Diuretics and salt restriction

Oxygen

Calcium channel blockers

Lung transplant

119
Q

Types of non-small cell lung cancers (NSCLC)

A

adenocarcinoma, squamous cell carcinoma, large cell

120
Q

Labs and diagnostic studies to eval for lung tumor

A
biopsy
cytology of sputum
CT to look for nodules
PET to look for metastasis
Thoracocentesis
Video assisted thoracic surgery (VATS)
121
Q

Pulmonary neoplasm most commonly found in large central bronchi

A

squamous cell carcinoma

122
Q

Most common lung cancer in non smokers

A

adenocarcinoma

123
Q

Most aggressive lung cancer with early metastasis

A

small cell carcinoma (oat cell)

124
Q

Definition of pulmonary nodule

A

less than 3 cm consolidation w/o other lung findings

125
Q

How should pulmonary nodule be managed?

A

watchful waiting with serial CT

126
Q

Acute onset of dyspnea and tachypnea in baby that does not respond to oxygen therapy

A

ARDS

127
Q

ARDS treatment

A

Typically mechanical ventilation
Treat underlying causes
Oxygen supplementation does NOT help

128
Q

Symptoms of respiratory distress in premature infant with diffuse ground glass appearance on CXR

A

Hyaline membrane disease

129
Q

Pathophysiology of hyaline membrane disease

A

insufficient surfactant production in premature infant

130
Q

Hyaline membrane disease treatment

A

Oxygen
CPAP
Intubation
Surfactant spray

131
Q

How can hyaline membrane disease be prevented?

A

Give steroids if risk of delivery before 34 weeks gestation

132
Q

I came in to see my physician assistant because of…

Wheezing
Drooling
Dyspnea
Foul smell

A

Foreign body aspiration

133
Q

CXR findings if foreign body aspiration

A

air trapping

134
Q

FEV1/FVC ratio in PFTs of obstructive and restrictive lung disease

A

decreased in obstructive (low FEV1)

same or increased in restrictive (low FVC)

135
Q

How are asthma and COPD differentiated?

A

asthma is reversible bronchoconstriction and PFT’s will improve with treatment

COPD is irreversible with chronic decrease in PFT’s

136
Q

How does the sympathetic and parasympathetic nervous system affect airways?

A

sympathetic dilates airways

parasympathetic constricts airways

137
Q

MOA of beta agonists in lungs

A

stimulates the sympathetic nervous system and dilates bronchioles

138
Q

Which drug class treats obstructive pulmonary diseases by inhibiting parasympathetic nervous system to open airways?

A

anticholinergics (ex. ipratropium)

139
Q

When would you not want to use a beta agonist to open airways?

A

if patient is on beta blocker or who needs beta blocker for angina or arrhythmias

140
Q

What are crackles heard on lung exam?

A

sound of stiff alveoli popping open

141
Q

A decreased _______ is hallmark of pulmonary fibrotic disease.

A

DLCO (diffusion defect)

142
Q

3 causes of pulmonary HTN

A

Resistance in lungs
Backup from left heart
Increased flow into right heart (eg. VSD)

143
Q

_________ is most common cause of pneumonia.

A

strep pneumo

144
Q

What is Light’s Criteria for pleural effusion?

A

fluid is exudative if any of following:
pleural fluid protein/serum protein ratio >0.5
pleural fluid LDH/serum LDH ratio >0.6
pleural fluid LDH level >2/3 upper limit for serum LDH

145
Q

empyema

A

pus in pleural space; complication of pneumonia or caused by penetrating chest trauma

146
Q

Hallmark of pleural effusion on XR

A

blunting of costophrenic angles

147
Q

What does hyper-resonance on percussion indicate?

A

more air than usual; seen in asthma, COPD, and pneumothorax

148
Q

tactile fremitus

A

feel vibrations on patient’s back as patient speaks

increased vibration if lung filled with something other than air