Public Health Flashcards
What are the three domains of public health?
Health improvement
Health protection
Improving services
What is health improvement?
Social interventions aimed at preventing disease, promoting health and reducing inequalities
Inequalities
Education
Housing
Employment
Lifestyles
What is health protection?
Measures to control infectious disease risks and environmental hazards
Infectious disease
Chemicals and poisons
Radiation
Environmental health hazards
What is improving services?
Organisation and delivery of safe, high quality services for prevention, treatment and care.
Clinical effectiveness
Efficiency
Service planning
Audit evaluation
Clinical governance
What is equality?
Treating everyone the same
Giving equal shares
What is equity?
Being fair
Giving everyone what they need to be successful
What is horizontal equity?
Equal treatment for equal need
What is vertical equity?
Unequal treatment for unequal need
What are the Bradford Hill criteria for causation?
- Temporality
- Dose-response
- Strength
- Reversibility
- Consistency
- Plausibility (biological)
- Coherence
- Analogy
- Specificity
What is temporality (most important)?
Exposure occurs prior to outcome
(People smoke before getting lung cancer)
What is dose-response?
Increased risk of outcome with increased exposure
(The more you smoke the more likely to get lung cancer)
What is strength?
The stronger the association between the exposure and the outcome, the less likely that the relationship is due to another factor
Very high relative risk
What is reversibility?
Intervention to reduce exposure reduces the outcome
What is consistency?
Same result observed from various studies in different geographical settings
What is plausibility?
Reasonable biological mechanism
What is coherence?
Logical consistency with other information
What is analogy?
Similarity with other established cause-effect relationships
What is specificity?
Relationship specific to outcome of interest
What can association be due to?
- Chance
- Bias
- Confounding
- Reverse causality
- A true causal assocaition
What is bias?
A systematic error that results in a deviation from the true effect of an exposure on an outcome
What are the three types of bias?
- Selection bias
- Information bias
- Publication bias
What is selection bias?
A systematic error in the selection of study participants or the allocation of participants to different study groups
What is information bias?
A systematic error in the measurement or classification of exposure or outcome. Sources of information bias: observer (observer bias), participant (e.g. recall bias) or instrument (e.g. wrongly calibrated).
Report inaccurate information because feel judged
What is publication bias?
Trials with negative results less likely to be published
What is lead time bias?
Early identification doesn’t alter outcome but appears to increase survival
e.g. patient knows they have the disease for longer
What is length time bias?
Disease that progress more slowly is more likely to be picked up by screening (i.e. symptom free and around for longer), which makes it appear that screening prolongs life.
What is confounding?
When an apparent association between an exposure and an outcome is actually the result of another factor
Study design?
Think retrospective vs prospective
Most useful are- systematic review/meta analysis then randomised control trial then cohort
What is a cross-sectional study?
Retrospective observational study collecting data from a population and a specific point in time
What are the advantages of a cross-sectional study?
Larger sample size
Rapid
Repeated studies show changes over time
What are the disadvantages of a cross-sectional study?
Risk of reverse causality- which came first?
Cannot measure incidence
Risk recall bias and non response
What is a case control study?
Retrospective observational study looking at population with disease and control population
What are the advantages of case control studies?
Good for rare outcomes
Rapid
What are the disadvantages of case control studies?
Prone to selection bias and information bias
Resource consuming to find well matched controls
What is a cohort study?
Prospective longitudinal study looking at separate cohorts with different treatments/exposures applied – await to see if disease occurs
What are the advantages of a cohort study?
Can establish disease risk factors (no chance or reverse causality as disease not happened yet)
Can follow rare exposure
Data on confounders can be collected prospectively
Less risk of selection and recall bias
What are the disadvantages of cohort studies?
Takes a long time
People may drop out
Large sample size required, expensive, time consuming
Difficult to assess rare diseases as may not develop