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Q3 Physio II Final > Puberty (lec 35) > Flashcards

Puberty (lec 35) Flashcards

1
Q

Genetic sex is?

A

combo of sex chromo at conception

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2
Q

Gonadal sex is?

A

testes or ovaries

determined by presence/absence of Y

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3
Q

Phenotypic sex is?

A

anatomic

determined by gonadal

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4
Q

Sex Determining Region (SRY) of Y chromo purpose?

A

makes testis determining factor (TDF)

in absence of TDF -> gonads become ovaries

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5
Q

Gonadal development?

A

1st 5 wks: gonads are indifferent
TDF -> testies wks 6-7
Ovaries wk 9

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6
Q

In males, Wolffian ducts become?

Mullerian ducts become?

A

via testosterone stim ->
epidid, deferens, sem vesc, ejac ducts

via antimullerian hormone ->
ducts atrophy

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7
Q

DHT role in male development?

A

(Testosterone changed to DHT by 5a-reductase)

wk 9-10 DHT stim differentiation of external genitalia

absence of DHT -> female gen development

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8
Q

In females, Mullerian ducts become?

Wolffian ducts become?

A

No hormone needed ->
fallop tubes, uterus, up 1/3 vagina

atrophy

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9
Q

Androgen Insensitivity Synd (Testicular Feminization)?

A

XY w/ no fxnl androgen receptors

Testes develop -> secrete AMH/testost

Both Wolffian/Mullerian ducts atrophy

Female external genitalia w/ blinded vagina,
Infertile,
Diagnosed at puberty

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10
Q

Female Pseudohermaphroditism?

A

XX w/ no 21-hydroxylase ->
no cortisol prdxn/excess androgen prdxn

Ovaries develop,
Mullerian develop/Wolff atrophy,
High androgens cause external genit to virilize,
Infertile

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11
Q

XY w/o SRY?

XX w/ SRY?

A

develop as female

develop as male

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12
Q

5α-reductase deficiency?

A 
male pseudohermaphroditism
(male internl/female external)

5a-reduc turns testosterone into DHT (necessary for external genitalia development in males)

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13
Q

XY w/ defective testis?

A

No testost prdxn = no internal genitalia, female-like external

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14
Q

XY w/ defective AMH?

A

Male and female internal with male external

wolf stim’d but mull not suppressed

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15
Q

Male puberty?

A

starts 9-14 yo
↑ testicle size
pubic hair
↑ penis size

Sperm/ejac develop ~ 13

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16
Q

Female puberty?

A

starts 8-13
thelarche (breasts) ->
pubarche ->
menarche

1st cycles w/o estrogen feedback so no ovulation

17
Q

Pubertal timing due to?

A

↓ suppression of GnRH or

↓ sensitivity to - feedback of est/test

18
Q

1st ↑ in GnRH release?

A

during sleep

↑ LH

19
Q

Puberty ºcontrol is?

A

body fat (energy resources)

20
Q

Leptin and puberty?

A

(Hormone from adipose)
regulates body weight/metabolism
stim puberty

21
Q

Melatonin and puberty?

A

(hormone from pineal gland)
synchs circadian rhythm
inhib GnRH release

22
Q

Precocious Puberty is?

A

2º development < 8F or <9M

23
Q

Gonadotropin-DEPENDENT Precocious Puberty (GDPP) caused by? (3)

A

↑ gonadotrophins (LH, FSH)
CNS tumor
Idiopathic

24
Q

Gonadotropin-INdependent Precocious Puberty (GIPP) caused by? (3)

A

Normal LH/FSH but ↑ gonadal hormones
Testicle/ovary disorder
Hormone-secreting tumors

25
Q

GDPP epidemiology?

Tx?

A

F»M

Long-acting GnRH agonist:
Initial ↑ ↑ FSH/LH release ->
down-reg/desens receptors ->
↓ gondadotropins

26
Q

GIPP tx?

A

tumor removal

27
Q

Delayed puberty is?

A

lack of physical maturation 2 SD beyond mean

28
Q

Hypogonadotropic Hypogonadism caused by? (3)

A

Low gonadotropins -> low gonad hormones
Deficient pulsatile release
Killman’s Synd

29
Q

Hypergonadotropic Hypogonadism caused by? (3)

A

Low gonadal hormones -> high gonadotropins from no - feeedback
Gonadal streak
Turner’s

30
Q

Kallman’s Synd?

A

M>F

Ø fetal migration of GnRH secretor neurons to hypothalm = ↓ gonadotropins

Tx: hormones

31
Q

Turner’s?

A

XO = Ø neg feedback
Female genital tract, Ø fxnl gonads

Tx: GH then sex hormones

32
Q

Klienfelter’s?

A

47 XXY
Feminization
Testicular failure

Q3 Physio II Final (5 decks)

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