PTS Endocrine Formative 1

Question 1

A 48-year-old man has a 4-month history of increasing fatigue and anorexia. He has lost 5.5 kg and noticed increased skin pigmentation. He has been otherwise healthy. His mother has Hashimoto’s thyroiditis and one of his sisters has type 1 diabetes. His blood pressure is 110/85 mmHg (supine) and 92/60 mmHg (sitting). His face shows signs of wasting and his skin has diffuse hyperpigmentation, which is more pronounced in the oral mucosa, palmar creases, and knuckles.

What condition does this man likely have?

A) Conn’s syndrome
B) Type 1 diabetes
C) Addison’s disease

Answer 1

C) Addison’s disease

Question 2

A 12-year-old girl is brought to the emergency department by her parents due to 12 hours of rapidly worsening nausea, vomiting, abdominal pain, and lethargy. Over the last week she has felt excessively thirsty and has been urinating a lot. Physical examination reveals a lean, dehydrated girl with deep rapid respirations, tachycardia, and no response to verbal commands.

What is the most likely condition she is suffering from?

A) Hyperosmolar- hyperglycaemic state
B) Diabetic Ketoacidosis
C) Adrenal crisis
D) Anaphylactic shock

Answer 2

B) Diabetic Ketoacidosis

Question 3

A 34-year-old woman presents with complaints of weight gain and irregular menses for the last several years. She has gained 20 kg over the past 3 years and feels that most of the weight gain is in her abdomen and face. She notes bruising without significant trauma, difficulty rising from a chair, and proximal muscle wasting. She was diagnosed with type 2 diabetes and hypertension 1 year ago.

What is the most likely condition she is suffering from?

A) Addison’s disease
B) Cushing syndrome
C) Pheochromocytoma
D) Polycystic Ovary Syndrome

Answer 3

B) Cushing syndrome