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Pharm > Psyco > Flashcards

Psyco Flashcards

0
Q

SNRI

A

Depression, can become mania
generalized anxiety,
panic disorder.
Diabetic peripheral neuropathy

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1
Q

SSRI

A 
social phobia.
Depression
OCD
bulimia
PTSD
generalized anxiety, 
panic disorder,
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2
Q

TCA

A 
bedweTTing
OCD
mAjor depression, 
fibromyalgia.
Side defect:
Convulsions, coma, cardiotoxicity.
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3
Q

MAO

A

Atypical depression, and society,
Contraindication: use with SSRI, TCA and St. John wort, meperidine,dexthorphan
Side effect:Hypertensive crisis

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4
Q

Tolerance of opiates does not develop in?

A

Miosis and constipation

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5
Q

methylphenidate

A

increase catecholamine at the synaptic cleft,especially ne and DA
used in ADHD, narcolepsy, appetite control
Chronic use will cause desentization, do not stop suddenly->suicidal

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6
Q

dextroamphetamine

A

increase catecholamine at the synaptic cleft,especially ne and DA
used in ADHD, narcolepsy, appetite control
Chronic use will cause desentization, do not stop suddenly->suicidal

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7
Q

methamphetamine

A

increase catecholamine at the synaptic cleft,especially ne and DA
used in ADHD, narcolepsy, appetite control
Chronic use will cause desentization, do not stop suddenly->suicidal

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8
Q

Haloperidol

A

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:+++, sedation,alpha blocker, m block:+, high potency
dystonia–>akathisia–>bradykinesia–>tardive dyskinesia
Neuroleptic malignant syndrome

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9
Q

trifluoperazine

azine

A

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal, sedation,alpha blocker, m block, high potency(EPS)
dystonia–>akathisia–>bradykinesia–>tardive dyskinesia
Neuroleptic malignant syndrome

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10
Q

fluphenazine

azine

A

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:+++, sedation,alpha blocker, m block:+,high potency
dystonia–>akathisia–>bradykinesia–>tardive dyskinesia
Neuroleptic malignant syndrome

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11
Q

thioridazine

azine

A

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:+, sedation,alpha blocker, m block:+++, low potency
dry mouth, constipation,hypotension, sedation,retinal deposition
Neuroleptic malignant syndrome

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12
Q

chlorpromazine

azine

A

*block DA D2 receptors(increase cAMP)
*used in schizophrenia, psychosis, acute mania, Tourette’s syndrome
*highly lipid soluble very slowly removed.
*extrapyramidal:++, sedation,alpha blocker, m block:+++, low potency
dry mouth, constipation,hypotension, sedation, corneal deposition
Neuroleptic malignant syndrome

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13
Q

olanzapine

A

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+;sedation:-; alpha block: ++, M block:+
significant weight gain!!!

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14
Q

clozapine

A

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+/-;sedation:+; alpha block: +++, M block:++
significant weight gain!!!
agranulosytosis(weekly WBC monitoring) and seizure

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15
Q

quetiapine

A

atypical antipschotic, block 5HT/ACh
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
sedation:++; alpha block: ++,
very expensive!!!!

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16
Q

risperiodone

A

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+;sedation:+/-; alpha block: ++, M block:+/-

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17
Q

aripiprazole

A

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS:+;sedation:+/-; alpha block: +/-, M block:+/-
partial anta D2, block 5-HT

18
Q

ziprasidone

A

atypical antipschotic,
schizo, both+and-; bipolar; OCD; anxiety;depression;mania; tourette
EPS;sedation; alpha block; M block:
prolong QT

19
Q

Lithium

A

*inhibit phosphoinositol cascade, IP3
*mood stabilizer for bipolar disorder, blocks relapse and acute manic events, also in SIADH
*tremor,sedation, edema, heart block, hypothyrodism(t4x>t3)
polyuria(ADH antagonist)–>nephrogenic DI
terotogenesis, fetal cardiac ebstein anomaly and vessel malformation
excrete by kidney, reabsorbed in proximal following Na
remove by amilorides, thiazide and loop all decreased clearance

20
Q

buspirone

A

stimulates 5-HT 1A receptors
generalized anxiety disorder, takes 1-2 wks to take effect
do not cause sadation, addiction, tolerance
do not interact with alcohol
“I am anxiety if the bus will come on time”

21
Q

venlafaxin

A

SNRI,inhibit reuptake of NE &5 HT, mild DA
antidepressant, general anxiety disorder,panic disorder
tox: increase BP, stimulant effects, sedation, nausea

22
Q

duoloxetine

A

SNRI,inhibit reuptake of NE &5 HT, greater effect on NE
antidepressant, diabetic peripheral neuorpathy
tox: increase BP, stimulant effects, sedation, nausea

23
Q

Atomoxetine

A

selective NE uptake inhibitor

24
Q

fluoxetine

A

SSRI, serotinin-specific reuptake inhibitor
anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety,
bulimia,depression
Tox: GI distress, sexual dysfunction,
serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

25
Q

paroxetine

A

SSRI, serotinin-specific reuptake inhibitor
anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety,
bulimia,depression
Tox: GI distress, sexual dysfunction,
serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

26
Q

sertraline

A

SSRI, serotinin-specific reuptake inhibitor
anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety,
bulimia,depression
Tox: GI distress, sexual dysfunction,
serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

27
Q

citalopram

A

SSRI, serotinin-specific reuptake inhibitor
anxiety: panic disorder,social phobia.OCD,PTSD,generalized anxiety,
bulimia,depression
Tox: GI distress, sexual dysfunction,
serotonin syndrome:hyperthermia, confusion, myoclonus, CV collapse, flushing, diarrhea, seizure, treat with cyproheptadine

28
Q

amitriptyline

A

TCA, blocks reuptake of NE and serotonin
major depression, fibromyalgia
sedation
alpha blocking-hypotension
M blocking-tachy, retention, dry mouth, more than alpha blocking
Triple c: convulsion, cardiotoxicity(NaHCO), Coma

29
Q

nortriptyline

A

TCA, blocks reuptake of NE and serotonin
use in: major depression, fibromyalgia
tox: sedation, alpha blocking-hypotension, less than amitriptyline
M blocking-tachy, retention, dry mouth,”confusion and hallucination in elderly”
Triple c: convulsion, cardiotoxicity(NaHCO), Coma,

30
Q

imipramine

A

TCA, blocks reuptake of NE and serotonin
major depression, fibromyalgia,BED WETTING
sedation
alpha blocking-hypotension
M blocking-tachy, retention, dry mouth,
Triple c: convulsion, cardiotoxicity(NaHCO), Coma

31
Q

DESIPRAMINE

A 
TCA, blocks reuptake of NE and serotonin
major depression, fibromyalgia
sedation
alpha blocking-hypotension
M blocking-tachy, retention, dry mouth, 
Triple c: convulsion, cardiotoxicity(NaHCO), Coma
32
Q

clomipramine

A 
TCA, blocks reuptake of NE and serotonin
major depression, fibromyalgia, "OCD"
sedation
alpha blocking-hypotension
M blocking-tachy, retention, dry mouth, 
Triple c: convulsion, cardiotoxicity(NaHCO), Coma
33
Q

doxepin

A 
TCA, blocks reuptake of NE and serotonin
major depression, fibromyalgia
sedation
alpha blocking-hypotension
M blocking-tachy, retention, dry mouth,
Triple c: convulsion, cardiotoxicity(NaHCO), Coma
34
Q

amoxapine

A 
TCA, blocks reuptake of NE and serotonin
major depression, fibromyalgia, "OCD"
sedation
alpha blocking-hypotension
M blocking-tachy, retention, dry mouth, 
Triple c: convulsion, cardiotoxicity(NaHCO), Coma
35
Q

tranylcypromine

A

nonselective MAO inhibitor increase amine neurotransmitter(NE, DA, 5-HT)
atypical depression,anxietym hypochondriasis
tox: HTN crisis (ingestion of tyramine), CNS stimulation
contraindicated with SSRI, TCA, St John’s Wort, meperidine, dextromethorphan

36
Q

Phenelzine

A

nonselective MAO inhibitor increase amine neurotransmitter(NE, DA, 5-HT)
atypical depression,anxietym hypochondriasis
tox: HTN crisis (ingestion of tyramine), CNS stimulation
contraindicated with SSRI, TCA, St John’s Wort, meperidine, dextromethorphan

37
Q

Isocarboxazid

A

nonselective MAO inhibitor increase amine neurotransmitter(NE, DA, 5-HT)
atypical depression,anxietym hypochondriasis
tox: HTN crisis (ingestion of tyramine), CNS stimulation
contraindicated with SSRI, TCA, St John’s Wort, meperidine, dextromethorphan

38
Q

selegiline

A

MAO-B: increase DA, used in Parkinson’s disease

39
Q

bupropion

A 
smoking cessation
increase NE and DA
Tox: stimulant effects: tachy, insomnia
headache
seizure in bulimic pts
no sexual effect
40
Q

varennidine

A

bind to Nic receptor

smoking cessation

41
Q

mirtazapine

A

alpha2 anta(increase release of NE and serotonin)
potent 5 HT2 and 5HT3 receptor antagonist
toxicity: sedation: helpful in depress pt with insomnia
increase appetite, weight gain: helpful in elderly or anorexis pt
dry mouth

42
Q

maprotiline

A

blocks NE reuptake

toxicity:sedation, orthostatic hypotension

43
Q

trazodone

A

primary inhibits serotonin reuptake
used primarily for insomnia as high doses are needed for antidepressant
TOX: sedation, nausea,
priapism:thrombosis->ischemia, prolonged erection
postural hypotension

Pharm (13 decks)

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